登録情報 データベース : PDB / ID : 5cl1 構造の表示 ダウンロードとリンクタイトル Complex structure of Norrin with human Frizzled 4 要素Frizzled-4 Maltose-binding periplasmic protein,Norrin 詳細キーワード SIGNALING PROTEIN / Wnt / Norrin / Frizzled機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
retina blood vessel maintenance / cone retinal bipolar cell differentiation / cerebellum vasculature morphogenesis / Wnt signaling pathway, calcium modulating pathway / Norrin signaling pathway / extracellular matrix-cell signaling / re-entry into mitotic cell cycle / progesterone secretion / retinal blood vessel morphogenesis / retinal rod cell differentiation ... retina blood vessel maintenance / cone retinal bipolar cell differentiation / cerebellum vasculature morphogenesis / Wnt signaling pathway, calcium modulating pathway / Norrin signaling pathway / extracellular matrix-cell signaling / re-entry into mitotic cell cycle / progesterone secretion / retinal blood vessel morphogenesis / retinal rod cell differentiation / locomotion involved in locomotory behavior / retina vasculature morphogenesis in camera-type eye / regulation of vascular endothelial growth factor receptor signaling pathway / ubiquitin-dependent endocytosis / Signaling by RNF43 mutants / WNT5A-dependent internalization of FZD4 / retina layer formation / retinal pigment epithelium development / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / establishment of blood-retinal barrier / Wnt receptor activity / glycine metabolic process / microglial cell proliferation / endothelial cell differentiation / dendritic spine development / Wnt-protein binding / establishment of blood-brain barrier / vacuole organization / protein targeting to lysosome / microglia differentiation / frizzled binding / Class B/2 (Secretin family receptors) / negative regulation of cell-substrate adhesion / positive regulation of dendrite morphogenesis / lens development in camera-type eye / exploration behavior / cytokine receptor activity / action potential / optic nerve development / smoothened signaling pathway / retinal ganglion cell axon guidance / cytokine binding / decidualization / carbohydrate transmembrane transporter activity / maltose binding / maltose transport / maltodextrin transmembrane transport / response to axon injury / blood vessel remodeling / canonical Wnt signaling pathway / vasculogenesis / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / cellular response to retinoic acid / tricarboxylic acid cycle / Regulation of FZD by ubiquitination / visual perception / glutathione metabolic process / substrate adhesion-dependent cell spreading / transforming growth factor beta receptor signaling pathway / Asymmetric localization of PCP proteins / cellular response to leukemia inhibitory factor / cytokine activity / PDZ domain binding / G protein-coupled receptor activity / sensory perception of sound / clathrin-coated endocytic vesicle membrane / neuron differentiation / Wnt signaling pathway / positive regulation of DNA-binding transcription factor activity / cell-cell junction / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / Ca2+ pathway / nervous system development / signaling receptor activity / mitotic cell cycle / amyloid-beta binding / cellular response to hypoxia / outer membrane-bounded periplasmic space / angiogenesis / neuron apoptotic process / collagen-containing extracellular matrix / cell population proliferation / transcription by RNA polymerase II / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / response to hypoxia / protein ubiquitination / positive regulation of cell migration / inflammatory response / protein heterodimerization activity / glutamatergic synapse / ubiquitin protein ligase binding / dendrite / protein-containing complex binding / positive regulation of DNA-templated transcription / cell surface / protein homodimerization activity / extracellular space / plasma membrane 類似検索 - 分子機能 Norrie disease protein / Frizzled-4 / Frizzled 4, cysteine-rich domain / Frizzled cysteine-rich domain / Frizzled cysteine-rich domain / Glycoprotein hormone subunit beta / Cystine-knot domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region ... Norrie disease protein / Frizzled-4 / Frizzled 4, cysteine-rich domain / Frizzled cysteine-rich domain / Frizzled cysteine-rich domain / Glycoprotein hormone subunit beta / Cystine-knot domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / C-terminal cystine knot signature. / C-terminal cystine knot domain profile. / Cystine knot, C-terminal / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / C-terminal cystine knot-like domain (CTCK) / Cystine-knot cytokine / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Maltose/maltodextrin-binding periplasmic protein / Norrin / Frizzled-4 類似検索 - 構成要素生物種 Escherichia coli O157:H7 (大腸菌)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.8 Å 詳細データ登録者 Wang, Z. / Ke, J. / Shen, G. / Cheng, Z. / Xu, H.E. / Xu, W. 引用ジャーナル : Cell Res. / 年 : 2015タイトル : Structural basis of the Norrin-Frizzled 4 interaction.著者 : Shen, G. / Ke, J. / Wang, Z. / Cheng, Z. / Gu, X. / Wei, Y. / Melcher, K. / Xu, H.E. / Xu, W. 履歴 登録 2015年7月16日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年8月12日 Provider : repository / タイプ : Initial release改定 1.1 2015年9月16日 Group : Database references改定 1.2 2020年7月29日 Group : Data collection / Derived calculations / Structure summaryカテゴリ : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / pdbx_struct_oper_list / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _pdbx_struct_oper_list.symmetry_operation 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 1.3 2023年9月27日 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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