Entry Database : PDB / ID : 5cjp Structure visualization Downloads & linksTitle The Structural Basis for Cdc42-Induced Dimerization of IQGAPs ComponentsCell division cycle 42 (GTP binding protein, 25kDa), isoform CRA_a Ras GTPase-activating-like protein IQGAP2 DetailsKeywords PROTEIN BINDING / IQGAP2 GAP related domain X-ray GTPase interactions Complex Cdc42Function / homology Function and homology informationFunction Domain/homology Component
: / establishment or maintenance of apical/basal cell polarity / thrombin-activated receptor signaling pathway / Arp2/3 complex-mediated actin nucleation / Arp2/3 complex binding / submandibular salivary gland formation / GBD domain binding / regulation of modification of postsynaptic structure / neuron fate determination / modification of synaptic structure ... : / establishment or maintenance of apical/basal cell polarity / thrombin-activated receptor signaling pathway / Arp2/3 complex-mediated actin nucleation / Arp2/3 complex binding / submandibular salivary gland formation / GBD domain binding / regulation of modification of postsynaptic structure / neuron fate determination / modification of synaptic structure / Golgi transport complex / positive regulation of pinocytosis / endothelin receptor signaling pathway involved in heart process / dendritic cell migration / cardiac neural crest cell migration involved in outflow tract morphogenesis / Cdc42 protein signal transduction / organelle transport along microtubule / positive regulation of synapse structural plasticity / GTPase inhibitor activity / storage vacuole / positive regulation of epithelial cell proliferation involved in lung morphogenesis / apolipoprotein A-I receptor binding / positive regulation of pseudopodium assembly / regulation of attachment of spindle microtubules to kinetochore / cardiac conduction system development / Inactivation of CDC42 and RAC1 / cell junction assembly / GTP-dependent protein binding / actin filament branching / establishment of epithelial cell apical/basal polarity / leading edge membrane / regulation of filopodium assembly / positive regulation of intracellular protein transport / establishment of Golgi localization / neuropilin signaling pathway / filopodium assembly / RHO GTPases activate KTN1 / embryonic heart tube development / thioesterase binding / regulation of stress fiber assembly / mitogen-activated protein kinase kinase kinase binding / cell projection assembly / Wnt signaling pathway, planar cell polarity pathway / nuclear migration / regulation of lamellipodium assembly / dendritic spine morphogenesis / regulation of actin cytoskeleton reorganization / adherens junction organization / DCC mediated attractive signaling / positive regulation of filopodium assembly / sprouting angiogenesis / CD28 dependent Vav1 pathway / heart contraction / RHOV GTPase cycle / regulation of mitotic nuclear division / positive regulation of cytokinesis / RHOJ GTPase cycle / regulation of protein binding / positive regulation of phosphatidylinositol 3-kinase activity / positive regulation of lamellipodium assembly / Golgi organization / RHOQ GTPase cycle / establishment or maintenance of cell polarity / RHO GTPases activate PAKs / Myogenesis / microvillus / phosphatidylinositol-3,4,5-trisphosphate binding / positive regulation of actin cytoskeleton reorganization / CDC42 GTPase cycle / RHOG GTPase cycle / macrophage differentiation / RHOU GTPase cycle / RHO GTPases activate IQGAPs / negative regulation of protein-containing complex assembly / RAC2 GTPase cycle / RAC3 GTPase cycle / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of DNA replication / G beta:gamma signalling through CDC42 / RHO GTPases Activate WASPs and WAVEs / regulation of actin cytoskeleton organization / spindle midzone / positive regulation of stress fiber assembly / regulation of GTPase activity / substantia nigra development / phagocytic vesicle / GPVI-mediated activation cascade / EPHB-mediated forward signaling / G protein activity / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / RAC1 GTPase cycle / small monomeric GTPase / GTPase activator activity / actin filament organization / secretory granule membrane / filopodium / phagocytosis, engulfment / RHO GTPases Activate Formins / cellular response to interferon-gamma / cell projection Similarity search - Function RasGAP protein, C-terminal / RasGAP C-terminus / GTPase Activation - p120GAP; domain 1 / GTPase Activation - p120gap; domain 1 / Cdc42 / Ras GTPase-activating protein, conserved site / Ras GTPase-activating proteins domain signature. / GTPase-activator protein for Ras-like GTPase / Ras GTPase-activating proteins profile. / GTPase-activator protein for Ras-like GTPases ... RasGAP protein, C-terminal / RasGAP C-terminus / GTPase Activation - p120GAP; domain 1 / GTPase Activation - p120gap; domain 1 / Cdc42 / Ras GTPase-activating protein, conserved site / Ras GTPase-activating proteins domain signature. / GTPase-activator protein for Ras-like GTPase / Ras GTPase-activating proteins profile. / GTPase-activator protein for Ras-like GTPases / Ras GTPase-activating domain / small GTPase Rho family profile. / IQ calmodulin-binding motif / Small GTPase Rho / Rho GTPase activation protein / Calponin homology domain / Short calmodulin-binding motif containing conserved Ile and Gln residues. / Calponin homology (CH) domain / Calponin homology domain / Calponin homology (CH) domain profile. / CH domain superfamily / IQ motif profile. / WW/rsp5/WWP domain signature. / IQ motif, EF-hand binding site / WW/rsp5/WWP domain profile. / WW domain / Rho (Ras homology) subfamily of Ras-like small GTPases / Small GTPase / Ras family / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / P-loop containing nucleoside triphosphate hydrolase / Rossmann fold / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homology Cell division control protein 42 homolog / GUANOSINE-5'-TRIPHOSPHATE / Cell division cycle 42 (GTP binding protein, 25kDa), isoform CRA_a / Ras GTPase-activating-like protein IQGAP2 Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 2.6 Å DetailsAuthors Worthylake, D.K. / Boyapati, V.K. / LeCour Jr, L. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) 5R01BM084072 United States
CitationJournal : Structure / Year : 2016Title : The Structural Basis for Cdc42-Induced Dimerization of IQGAPs.Authors : LeCour, L. / Boyapati, V.K. / Liu, J. / Li, Z. / Sacks, D.B. / Worthylake, D.K. History Deposition Jul 14, 2015 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 10, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Aug 31, 2016 Group : Database referencesRevision 1.2 Sep 14, 2016 Group : Database referencesRevision 1.3 Sep 20, 2017 Group : Author supporting evidence / Database references / Derived calculationsCategory : citation / pdbx_audit_support / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operationRevision 1.4 Dec 25, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization
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