登録情報 | データベース: PDB / ID: 5cep |
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タイトル | DLK in complex with inhibitor N-(1-isopropyl-5-(piperidin-4-yl)-1H-pyrazol-3-yl)-4-(trifluoromethyl)pyridin-2-amine |
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要素 | Mitogen-activated protein kinase kinase kinase 12 |
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キーワード | TRANSFERASE/TRANSFERASE Inhibitor / kinase / TRANSFERASE-TRANSFERASE Inhibitor complex |
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機能・相同性 | 機能・相同性情報
mitogen-activated protein kinase kinase kinase / negative regulation of motor neuron apoptotic process / MAP kinase kinase kinase activity / JNK cascade / post-translational protein modification / protein serine/threonine kinase activator activity / growth cone / protein autophosphorylation / positive regulation of ERK1 and ERK2 cascade / protein phosphorylation ...mitogen-activated protein kinase kinase kinase / negative regulation of motor neuron apoptotic process / MAP kinase kinase kinase activity / JNK cascade / post-translational protein modification / protein serine/threonine kinase activator activity / growth cone / protein autophosphorylation / positive regulation of ERK1 and ERK2 cascade / protein phosphorylation / protein kinase activity / intracellular signal transduction / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / positive regulation of DNA-templated transcription / protein homodimerization activity / ATP binding / membrane / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Mitogen-activated protein kinase kinase kinase 12/13 / Mitogen-activated protein kinase kinase kinase 12 / : / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site ...Mitogen-activated protein kinase kinase kinase 12/13 / Mitogen-activated protein kinase kinase kinase 12 / : / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-50E / Mitogen-activated protein kinase kinase kinase 12類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.99 Å |
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データ登録者 | HARRIS, S.F. / YIN, J. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2015 タイトル: Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). 著者: Patel, S. / Harris, S.F. / Gibbons, P. / Deshmukh, G. / Gustafson, A. / Kellar, T. / Lin, H. / Liu, X. / Liu, Y. / Liu, Y. / Ma, C. / Scearce-Levie, K. / Ghosh, A.S. / Shin, Y.G. / Solanoy, H. ...著者: Patel, S. / Harris, S.F. / Gibbons, P. / Deshmukh, G. / Gustafson, A. / Kellar, T. / Lin, H. / Liu, X. / Liu, Y. / Liu, Y. / Ma, C. / Scearce-Levie, K. / Ghosh, A.S. / Shin, Y.G. / Solanoy, H. / Wang, J. / Wang, B. / Yin, J. / Siu, M. / Lewcock, J.W. |
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履歴 | 登録 | 2015年7月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年10月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年11月4日 | Group: Database references |
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改定 1.2 | 2024年3月6日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / database_2 / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _database_2.pdbx_DOI ..._citation.journal_id_CSD / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation |
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