登録情報 データベース : PDB / ID : 5btr 構造の表示 ダウンロードとリンクタイトル Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide 要素AMC-containing peptide NAD-dependent protein deacetylase sirtuin-1 詳細キーワード HYDROLASE/SUBSTRATE / Deacetylase / Human Sirtuin 1 / N-terminal domain / Catalytic domain / C-terminal domain / Resveratrol / Substrate / HYDROLASE-SUBSTRATE complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of prostaglandin biosynthetic process / regulation of smooth muscle cell apoptotic process / maintenance of nucleus location / eNoSc complex / histone H4K12 deacetylase activity / histone H3K deacetylase activity / NAD-dependent histone decrotonylase activity / negative regulation of attachment of mitotic spindle microtubules to kinetochore / negative regulation of cellular response to testosterone stimulus / protein depropionylation ... negative regulation of prostaglandin biosynthetic process / regulation of smooth muscle cell apoptotic process / maintenance of nucleus location / eNoSc complex / histone H4K12 deacetylase activity / histone H3K deacetylase activity / NAD-dependent histone decrotonylase activity / negative regulation of attachment of mitotic spindle microtubules to kinetochore / negative regulation of cellular response to testosterone stimulus / protein depropionylation / protein-propionyllysine depropionylase activity / regulation of peroxisome proliferator activated receptor signaling pathway / regulation of transcription by glucose / regulation of protein serine/threonine kinase activity / positive regulation of macrophage apoptotic process / NAD-dependent histone H3K14 deacetylase activity / negative regulation of triglyceride biosynthetic process / regulation of endodeoxyribonuclease activity / triglyceride mobilization / behavioral response to starvation / pyrimidine dimer repair by nucleotide-excision repair / HLH domain binding / regulation of lipid storage / keratin filament binding / leptin-mediated signaling pathway / NAD-dependent histone H3K9 deacetylase activity / negative regulation of peptidyl-lysine acetylation / NAD-dependent histone H4K16 deacetylase activity / regulation of brown fat cell differentiation / deacetylase activity / positive regulation of smooth muscle cell differentiation / bHLH transcription factor binding / response to leptin / positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / intracellular triglyceride homeostasis / peptidyl-lysine acetylation / negative regulation of androgen receptor signaling pathway / positive regulation of adaptive immune response / regulation of centrosome duplication / rDNA heterochromatin / ovulation from ovarian follicle / single strand break repair / negative regulation of cAMP-dependent protein kinase activity / regulation of bile acid biosynthetic process / NAD-dependent protein lysine deacetylase activity / rDNA heterochromatin formation / protein acetyllysine N-acetyltransferase / negative regulation of protein acetylation / chromatin silencing complex / negative regulation of phosphorylation / DNA methylation-dependent heterochromatin formation / protein deacetylation / NAD-dependent histone deacetylase activity / positive regulation of MHC class II biosynthetic process / UV-damage excision repair / protein lysine deacetylase activity / positive regulation of cAMP-dependent protein kinase activity / negative regulation of TOR signaling / negative regulation of helicase activity / positive regulation of macrophage cytokine production / mitogen-activated protein kinase binding / positive regulation of double-strand break repair / Regulation of FOXO transcriptional activity by acetylation / DNA repair-dependent chromatin remodeling / nuclear inner membrane / muscle organ development / stress-induced premature senescence / histone deacetylase activity / DNA synthesis involved in DNA repair / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / negative regulation of NF-kappaB transcription factor activity / negative regulation of fat cell differentiation / intracellular glucose homeostasis / negative regulation of cellular senescence / negative regulation of DNA damage response, signal transduction by p53 class mediator / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / macrophage differentiation / positive regulation of macroautophagy / negative regulation of cell cycle / white fat cell differentiation / regulation of glucose metabolic process / NAD+ binding / Regulation of HSF1-mediated heat shock response / positive regulation of cholesterol efflux / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / positive regulation of blood vessel endothelial cell migration / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / fatty acid homeostasis / heterochromatin / cellular response to glucose starvation / heterochromatin formation / energy homeostasis / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / regulation of cellular response to heat / positive regulation of insulin receptor signaling pathway / negative regulation of canonical NF-kappaB signal transduction / positive regulation of gluconeogenesis / 転移酵素; アシル基を移すもの; アミノアシル基以外のアシル基を移すもの / positive regulation of endothelial cell proliferation / regulation of mitotic cell cycle 類似検索 - 分子機能 SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Rossmann fold ... SIR2/SIRT2 'Small Domain' / SIR2/SIRT2 'Small Domain' / Sirtuin, catalytic core small domain superfamily / Sirtuin family / Sir2 family / Sirtuin family, catalytic core domain / Sirtuin catalytic domain profile. / TPP-binding domain / DHS-like NAD/FAD-binding domain superfamily / Rossmann fold / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 RESVERATROL / NAD-dependent protein deacetylase sirtuin-1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)synthetic (人工物) 手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.2 Å 詳細データ登録者 Cao, D. / Wang, M. / Qiu, X. / Liu, D. / Jiang, H. / Yang, N. / Xu, R.M. 資金援助 中国, 6件 詳細 詳細を隠す組織 認可番号 国 Ministry of Science and Technology (China) 2012CB910702 中国 National Natural Science Foundation of China 31430018 中国 National Natural Science Foundation of China 31210103914 中国 Strategic Priority Research Program of Chinese Academy of Sciences XDB08010100 中国 Key Research Program of Chinese Academy of Sciences KJZD-EW-L05 中国 National Key New Drug Creation and Manufacturing Program of China 2014ZX09507002 中国
引用ジャーナル : Genes Dev. / 年 : 2015タイトル : Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol著者 : Cao, D. / Wang, M. / Qiu, X. / Liu, D. / Jiang, H. / Yang, N. / Xu, R.M. 履歴 登録 2015年6月3日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2015年7月8日 Provider : repository / タイプ : Initial release改定 1.1 2016年12月28日 Group : Other改定 1.2 2017年10月18日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.3 2023年11月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn_type.id
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