Entry Database : PDB / ID : 5bnh Structure visualization Downloads & linksTitle Crystal structure of the HLTF HIRAN domain with a ssDNA fragment ComponentsDNA (5'-D(*(GD)P*GP*TP*G)-3')DNA (5'-D(*(TD)P*TP*G)-3')Helicase-like transcription factor DetailsKeywords DNA BINDING PROTEIN/DNA / DNA damage / DNA recognition / DNA binding domain / DNA BINDING PROTEIN-DNA complexFunction / homology Function and homology informationFunction Domain/homology Component
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / ATP-dependent chromatin remodeler activity / regulation of neurogenesis / ATP-dependent activity, acting on DNA / helicase activity / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / RING-type E3 ubiquitin transferase / mRNA transcription by RNA polymerase II / nuclear matrix / RNA polymerase II transcription regulator complex ... hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides / ATP-dependent chromatin remodeler activity / regulation of neurogenesis / ATP-dependent activity, acting on DNA / helicase activity / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / RING-type E3 ubiquitin transferase / mRNA transcription by RNA polymerase II / nuclear matrix / RNA polymerase II transcription regulator complex / ubiquitin protein ligase activity / E3 ubiquitin ligases ubiquitinate target proteins / protein ubiquitination / DNA repair / ubiquitin protein ligase binding / nucleolus / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / zinc ion binding / nucleoplasm / ATP binding / membrane / nucleus / plasma membrane / cytoplasm Similarity search - Function HIRAN domain / HIRAN domain / HIRAN / Zinc finger, C3HC4 type (RING finger) / : / SNF2-like, N-terminal domain superfamily / SNF2, N-terminal / SNF2-related domain / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. ... HIRAN domain / HIRAN domain / HIRAN / Zinc finger, C3HC4 type (RING finger) / : / SNF2-like, N-terminal domain superfamily / SNF2, N-terminal / SNF2-related domain / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Ring finger / Helicase conserved C-terminal domain / Zinc finger RING-type profile. / Zinc finger, RING-type / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Zinc finger, RING/FYVE/PHD-type / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Homo sapiens (human)SYNTHETIC CONSTRUCT (others) Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 1.7 Å DetailsAuthors Neculai, D. / Walker, J.R. / Weigelt, J. / Bountra, C. / Edwards, A.M. / Arrowsmith, C.H. / Dhe-Paganon, S. CitationJournal : To Be Published Title : Co-crystal structure of the HLTF HIRAN domain with a ssDNA fragmentAuthors : Neculai, D. / Walker, J.R. / Weigelt, J. / Bountra, C. / Edwards, A.M. / Arrowsmith, C.H. / Dhe-Paganon, S. History Deposition May 26, 2015 Deposition site : RCSB / Processing site : PDBJRevision 1.0 May 25, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Sep 21, 2016 Group : Source and taxonomyRevision 1.2 Mar 20, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / pdbx_struct_oper_list / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _pdbx_struct_oper_list.symmetry_operation / _struct_conn.pdbx_dist_value / _struct_conn.ptnr2_auth_seq_id
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