Entry Database : PDB / ID : 5a6i Structure visualization Downloads & linksTitle V122I Transthyretin structure in complex with Tolcalpone ComponentsTRANSTHYRETIN Details Keywords TRANSPORT PROTEIN / TRANSPROT PROTEIN / TRANSTHYRETIN / AMYLOIDFunction / homology Function and homology informationFunction Domain/homology Component
Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ... Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein binding Similarity search - Function Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family ... Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.86 Å DetailsAuthors Reverter, D. / Gallego, P. / Santana, R. / Ventura, S. CitationJournal : Nat.Commun. / Year : 2016Title : Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular ToxicityAuthors : Reverter, D. / Gallego, P. / Santana, R. / Ventura, S. History Deposition Jun 26, 2015 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 24, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Mar 2, 2016 Group : Database referencesRevision 1.2 Aug 23, 2017 Group : Data collection / Category : diffrn_detector / Item : _diffrn_detector.typeRevision 1.3 May 8, 2024 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_struct_special_symmetry / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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