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TitleRepositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Journal, issue, pagesNat. Commun., Vol. 7, Page 10787-, Year 2016
Publish dateNov 21, 2014 (structure data deposition date)
AuthorsReverter, D. / Gallego, P. / Santana, R. / Ventura, S.
External linksNat. Commun. / PubMed:26902880
MethodsX-ray diffraction
Resolution1.15 - 1.86 Å
Structure data

PDB-4d7b:
Structure of human transthyretin in complex with Tolcapone
Method: X-RAY DIFFRACTION / Resolution: 1.15 Å

PDB-5a6i:
V122I Transthyretin structure in complex with Tolcalpone
Method: X-RAY DIFFRACTION / Resolution: 1.86 Å

Chemicals

ChemComp-TCW:
Tolcapone / medication, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / AMYLOIDOGENESIS / TRANSPROT PROTEIN / TRANSTHYRETIN / AMYLOID

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