登録情報 | データベース: PDB / ID: 4zgm |
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タイトル | Crystal structure of Semaglutide peptide backbone in complex with the GLP-1 receptor extracellular domain |
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要素 | - Glucagon-like peptide 1 receptor
- Semaglutide peptide backbone; 8Aib,34R-GLP-1(7-37)-OH
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キーワード | SIGNALING PROTEIN / GLP-1 / receptor / complex |
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機能・相同性 | 機能・相同性情報
glucagon receptor binding / glucagon-like peptide 1 receptor activity / glucagon receptor activity / hormone secretion / positive regulation of blood pressure / negative regulation of execution phase of apoptosis / post-translational protein targeting to membrane, translocation / feeding behavior / response to psychosocial stress / regulation of heart contraction ...glucagon receptor binding / glucagon-like peptide 1 receptor activity / glucagon receptor activity / hormone secretion / positive regulation of blood pressure / negative regulation of execution phase of apoptosis / post-translational protein targeting to membrane, translocation / feeding behavior / response to psychosocial stress / regulation of heart contraction / positive regulation of calcium ion import / cellular response to glucagon stimulus / positive regulation of insulin secretion involved in cellular response to glucose stimulus / peptide hormone binding / regulation of insulin secretion / Synthesis, secretion, and deacylation of Ghrelin / activation of adenylate cyclase activity / positive regulation of gluconeogenesis / protein kinase A signaling / negative regulation of blood pressure / cAMP-mediated signaling / positive regulation of peptidyl-threonine phosphorylation / response to activity / gluconeogenesis / adenylate cyclase-modulating G protein-coupled receptor signaling pathway / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / Glucagon signaling in metabolic regulation / Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) / Glucagon-type ligand receptors / Glucagon-like Peptide-1 (GLP1) regulates insulin secretion / transmembrane signaling receptor activity / positive regulation of peptidyl-serine phosphorylation / glucose homeostasis / positive regulation of cytosolic calcium ion concentration / G alpha (s) signalling events / G alpha (q) signalling events / secretory granule lumen / positive regulation of ERK1 and ERK2 cascade / learning or memory / cell surface receptor signaling pathway / G protein-coupled receptor signaling pathway / endoplasmic reticulum lumen / signaling receptor binding / negative regulation of apoptotic process / extracellular space / extracellular region / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 GPCR, family 2, extracellular hormone receptor domain / Glucagon / Hormone receptor fold / : / GPCR, family 2, glucagon-like peptide-1 receptor / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / GPCR, family 2, glucagon-like peptide-1/glucagon receptor ...GPCR, family 2, extracellular hormone receptor domain / Glucagon / Hormone receptor fold / : / GPCR, family 2, glucagon-like peptide-1 receptor / Glucagon/GIP/secretin/VIP / Peptide hormone / Glucagon / GIP / secretin / VIP family signature. / Glucagon like hormones / GPCR, family 2, glucagon-like peptide-1/glucagon receptor / : / G-protein coupled receptors family 2 signature 1. / Hormone receptor domain / GPCR, family 2, extracellular hormone receptor domain / G-protein coupled receptors family 2 profile 1. / Domain present in hormone receptors / GPCR family 2, extracellular hormone receptor domain superfamily / G-protein coupled receptors family 2 signature 2. / GPCR, family 2, secretin-like, conserved site / GPCR, family 2, secretin-like / 7 transmembrane receptor (Secretin family) / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Few Secondary Structures / Irregular類似検索 - ドメイン・相同性 3,6,9,12,15,18-hexaoxahexacosan-1-ol / Pro-glucagon / Glucagon-like peptide 1 receptor類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.8 Å |
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データ登録者 | Reedtz-Runge, S. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2015 タイトル: Discovery of the Once-Weekly Glucagon-Like Peptide-1 (GLP-1) Analogue Semaglutide. 著者: Lau, J. / Bloch, P. / Schaffer, L. / Pettersson, I. / Spetzler, J. / Kofoed, J. / Madsen, K. / Knudsen, L.B. / McGuire, J. / Steensgaard, D.B. / Strauss, H.M. / Gram, D.X. / Knudsen, S.M. / ...著者: Lau, J. / Bloch, P. / Schaffer, L. / Pettersson, I. / Spetzler, J. / Kofoed, J. / Madsen, K. / Knudsen, L.B. / McGuire, J. / Steensgaard, D.B. / Strauss, H.M. / Gram, D.X. / Knudsen, S.M. / Nielsen, F.S. / Thygesen, P. / Reedtz-Runge, S. / Kruse, T. |
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履歴 | 登録 | 2015年4月23日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2015年9月9日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年9月23日 | Group: Database references |
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改定 1.2 | 2015年10月7日 | Group: Database references |
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改定 1.3 | 2024年1月10日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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