登録情報 | データベース: PDB / ID: 4z1h |
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タイトル | Crystal structure of human Trap1 with SMTIN-P01 |
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要素 | Heat shock protein 75 kDa, mitochondrial |
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キーワード | CHAPERONE / Mitochondrial Hsp90 |
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機能・相同性 | 機能・相同性情報
translational attenuation / negative regulation of cellular respiration / Citric acid cycle (TCA cycle) / tumor necrosis factor receptor binding / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / Respiratory electron transport / negative regulation of reactive oxygen species biosynthetic process / chaperone-mediated protein folding / cell periphery / ATP-dependent protein folding chaperone ...translational attenuation / negative regulation of cellular respiration / Citric acid cycle (TCA cycle) / tumor necrosis factor receptor binding / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / Respiratory electron transport / negative regulation of reactive oxygen species biosynthetic process / chaperone-mediated protein folding / cell periphery / ATP-dependent protein folding chaperone / mitochondrial intermembrane space / unfolded protein binding / protein folding / mitochondrial inner membrane / mitochondrial matrix / protein kinase binding / ATP hydrolysis activity / mitochondrion / RNA binding / nucleoplasm / ATP binding / membrane類似検索 - 分子機能 HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold類似検索 - ドメイン・相同性 Chem-4KP / Heat shock protein 75 kDa, mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 2.9 Å |
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データ登録者 | Lee, C. / Park, H.K. / Ryu, J.H. / Kang, B.H. |
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引用 | ジャーナル: J.Am.Chem.Soc. / 年: 2015 タイトル: Development of a Mitochondria-Targeted Hsp90 Inhibitor Based on the Crystal Structures of Human TRAP1 著者: Lee, C. / Park, H.K. / Jeong, H. / Lim, J. / Lee, A.J. / Cheon, K.Y. / Kim, C.S. / Thomas, A.P. / Bae, B. / Kim, N.D. / Kim, S.H. / Suh, P.G. / Ryu, J.H. / Kang, B.H. |
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履歴 | 登録 | 2015年3月27日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2015年4月22日 | Provider: repository / タイプ: Initial release |
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