Entry | Database: PDB / ID: 4y9g |
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Title | Crystal structure of V30M mutated transthyretin in complex with 3-isomangostin |
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Components | Transthyretin |
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Keywords | TRANSPORT PROTEIN/INHIBITOR / transthyretin / inhibitor / natural product / mangostin / transporter / amyloidosis / kinetic stabilizer / TRANSPORT PROTEIN-INHIBITOR complex |
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Function / homology | Function and homology information
Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation ...Retinoid cycle disease events / The canonical retinoid cycle in rods (twilight vision) / thyroid hormone binding / purine nucleobase metabolic process / Non-integrin membrane-ECM interactions / Retinoid metabolism and transport / hormone activity / azurophil granule lumen / Amyloid fiber formation / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / identical protein bindingSimilarity search - Function Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family ...Transthyretin/hydroxyisourate hydrolase domain / Transthyretin, conserved site / Transthyretin signature 2. / Transthyretin, thyroxine binding site / Transthyretin signature 1. / Transthyretin / Transthyretin/hydroxyisourate hydrolase / Transthyretin/hydroxyisourate hydrolase domain / Transthyretin/hydroxyisourate hydrolase domain superfamily / HIUase/Transthyretin family / Immunoglobulin-like / Sandwich / Mainly BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.89 Å |
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Authors | Yokoyama, T. / Mizuguchi, M. |
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Funding support | Japan, 2items Organization | Grant number | Country |
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Takeda Science Foundation | | Japan | Amyloidosis Research Committee from the Ministry of Health, Labour, and Welware | | Japan |
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Citation | Journal: Sci Rep / Year: 2015 Title: Discovery of gamma-Mangostin as an Amyloidogenesis Inhibitor Authors: Yokoyama, T. / Ueda, M. / Ando, Y. / Mizuguchi, M. |
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History | Deposition | Feb 17, 2015 | Deposition site: RCSB / Processing site: PDBJ |
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Revision 1.0 | Sep 9, 2015 | Provider: repository / Type: Initial release |
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Revision 1.1 | Feb 5, 2020 | Group: Data collection / Derived calculations Category: diffrn_source / pdbx_prerelease_seq / pdbx_struct_oper_list Item: _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operation |
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Revision 1.2 | Nov 8, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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