Entry Database : PDB / ID : 4y2b Structure visualization Downloads & linksTitle Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A ComponentsHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A Details Keywords HYDROLASE/HYDROLASE INHIBITOR / phosphodiesterase / PDE7A / cAMP / HYDROLASE-HYDROLASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
3',5'-cyclic-AMP phosphodiesterase / cAMP catabolic process / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP-mediated signaling / G alpha (s) signalling events / perinuclear region of cytoplasm / nucleus / metal ion binding / cytosol Similarity search - Function Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. ... Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.2 Å DetailsAuthors Endo, Y. / Kawai, K. / Asano, T. / Amano, S. / Asanuma, Y. / Sawada, K. / Onodera, Y. / Ueo, N. / Takahashi, N. / Sonoda, Y. ...Endo, Y. / Kawai, K. / Asano, T. / Amano, S. / Asanuma, Y. / Sawada, K. / Onodera, Y. / Ueo, N. / Takahashi, N. / Sonoda, Y. / Kamei, N. / Irie, T. CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2015Title : 2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacyAuthors : Endo, Y. / Kawai, K. / Asano, T. / Amano, S. / Asanuma, Y. / Sawada, K. / Onodera, Y. / Ueo, N. / Takahashi, N. / Sonoda, Y. / Kamei, N. / Irie, T. History Deposition Feb 9, 2015 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Apr 8, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Apr 29, 2015 Group : Database referencesRevision 1.2 May 6, 2015 Group : Database referencesRevision 1.3 Oct 4, 2017 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Source and taxonomy Category : citation / diffrn_detector ... citation / diffrn_detector / entity_src_gen / pdbx_struct_oper_list Item : _citation.journal_id_CSD / _diffrn_detector.detector ... _citation.journal_id_CSD / _diffrn_detector.detector / _entity_src_gen.pdbx_alt_source_flag / _pdbx_struct_oper_list.symmetry_operation Revision 1.4 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id
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