登録情報 データベース : PDB / ID : 4xo6 構造の表示 ダウンロードとリンクタイトル Crystal structure of human 3-alpha hydroxysteroid dehydrogenase type 3 in complex with NADP+, 5alpha-androstan-3,17-dione and (3beta, 5alpha)-3-hydroxyandrostan-17-one 要素Aldo-keto reductase family 1 member C2 詳細 キーワード OXIDOREDUCTASE / ALPHA-BETA BARREL / HUMAN 3-ALPHA HDS3 / AKR / AKR1C2 / ALDO-KETO REDUCTASE / NADPH機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
indanol dehydrogenase / trans-1,2-dihydrobenzene-1,2-diol dehydrogenase / trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity / 3(or 17)alpha-hydroxysteroid dehydrogenase / indanol dehydrogenase activity / 3alpha-hydroxysteroid 3-dehydrogenase / : / cellular response to jasmonic acid stimulus / androsterone dehydrogenase activity / 3alpha(or 20beta)-hydroxysteroid dehydrogenase ... indanol dehydrogenase / trans-1,2-dihydrobenzene-1,2-diol dehydrogenase / trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity / 3(or 17)alpha-hydroxysteroid dehydrogenase / indanol dehydrogenase activity / 3alpha-hydroxysteroid 3-dehydrogenase / : / cellular response to jasmonic acid stimulus / androsterone dehydrogenase activity / 3alpha(or 20beta)-hydroxysteroid dehydrogenase / androstan-3-alpha,17-beta-diol dehydrogenase activity / cellular response to prostaglandin D stimulus / ketosteroid monooxygenase activity / Synthesis of bile acids and bile salts via 24-hydroxycholesterol / progesterone metabolic process / carboxylic acid binding / 17beta-estradiol 17-dehydrogenase / estradiol 17-beta-dehydrogenase [NAD(P)+] activity / 酸化還元酵素 / daunorubicin metabolic process / doxorubicin metabolic process / oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor / bile acid binding / aldose reductase (NADPH) activity / prostaglandin metabolic process / steroid metabolic process / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / digestion / epithelial cell differentiation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / G protein-coupled receptor signaling pathway / positive regulation of cell population proliferation / cytosol 類似検索 - 分子機能 Aldo-keto reductase family 1 member C / Aldo/keto reductase family putative active site signature. / NADP-dependent oxidoreductase domain / Aldo/keto reductase family signature 2. / Aldo/keto reductase, conserved site / Aldo-keto reductase / NADP-dependent oxidoreductase domain / Aldo/keto reductase family / NADP-dependent oxidoreductase domain superfamily / TIM Barrel ... Aldo-keto reductase family 1 member C / Aldo/keto reductase family putative active site signature. / NADP-dependent oxidoreductase domain / Aldo/keto reductase family signature 2. / Aldo/keto reductase, conserved site / Aldo-keto reductase / NADP-dependent oxidoreductase domain / Aldo/keto reductase family / NADP-dependent oxidoreductase domain superfamily / TIM Barrel / Alpha-Beta Barrel / Alpha Beta 類似検索 - ドメイン・相同性 5ALPHA-ANDROSTAN-3,17-DIONE / (3Beta,5alpha)-3-Hydroxyandrostan-17-one / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Aldo-keto reductase family 1 member C2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.2 Å 詳細データ登録者 Zhang, B. / Hu, X.-J. / Lin, S.-X. 資金援助 カナダ, 1件 詳細 詳細を隠す組織 認可番号 国 Canadian Institutes of Health Research (CIHR) MOP 97917 カナダ
引用ジャーナル : Biochem.J. / 年 : 2016タイトル : Human 3 alpha-hydroxysteroid dehydrogenase type 3: structural clues of 5 alpha-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth.著者 : Zhang, B. / Hu, X.J. / Wang, X.Q. / Theriault, J.F. / Zhu, D.W. / Shang, P. / Labrie, F. / Lin, S.X. 履歴 登録 2015年1月16日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2016年2月17日 Provider : repository / タイプ : Initial release改定 1.1 2016年3月16日 Group : Database references改定 1.2 2016年4月20日 Group : Database references改定 1.3 2017年9月6日 Group : Author supporting evidence / Database references / Derived calculationsカテゴリ : citation / pdbx_audit_support / pdbx_struct_oper_listItem : _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation改定 1.4 2020年1月8日 Group : Author supporting evidence / カテゴリ : pdbx_audit_support / Item : _pdbx_audit_support.funding_organization改定 1.5 2024年2月28日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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