Entry Database : PDB / ID : 4x7i Structure visualization Downloads & linksTitle Crystal Structure of BACE with amino thiazine inhibitor LY2886721 ComponentsBeta-secretase 1 Details Keywords HYDROLASE/HYDROLASE INHIBITOR / BACE / beta-secretase / inhibitor / complex / HYDROLASE-HYDROLASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / early endosome / lysosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane Similarity search - Function Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 1.77 Å DetailsAuthors Timm, D.E. CitationJournal : J.Neurosci. / Year : 2015Title : The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A beta Pharmacodynamic Responses in Mice, Dogs, and Humans.Authors: May, P.C. / Willis, B.A. / Lowe, S.L. / Dean, R.A. / Monk, S.A. / Cocke, P.J. / Audia, J.E. / Boggs, L.N. / Borders, A.R. / Brier, R.A. / Calligaro, D.O. / Day, T.A. / Ereshefsky, L. / ... Authors : May, P.C. / Willis, B.A. / Lowe, S.L. / Dean, R.A. / Monk, S.A. / Cocke, P.J. / Audia, J.E. / Boggs, L.N. / Borders, A.R. / Brier, R.A. / Calligaro, D.O. / Day, T.A. / Ereshefsky, L. / Erickson, J.A. / Gevorkyan, H. / Gonzales, C.R. / James, D.E. / Jhee, S.S. / Komjathy, S.F. / Li, L. / Lindstrom, T.D. / Mathes, B.M. / Martenyi, F. / Sheehan, S.M. / Stout, S.L. / Timm, D.E. / Vaught, G.M. / Watson, B.M. / Winneroski, L.L. / Yang, Z. / Mergott, D.J. History Deposition Dec 9, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 24, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Feb 4, 2015 Group : Database referencesRevision 1.2 Nov 22, 2017 Group : Derived calculations / Refinement description / Source and taxonomyCategory : entity_src_gen / pdbx_struct_oper_list / softwareItem : _entity_src_gen.pdbx_alt_source_flag / _pdbx_struct_oper_list.symmetry_operation
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