+Open data
-Basic information
Entry | Database: PDB / ID: 4x6z | ||||||
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Title | Yeast 20S proteasome in complex with PR-VI modulator | ||||||
Components |
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Keywords | HYDROLASE / 20S proteasome / low-molecular mass activators / allosteric regulation | ||||||
Function / homology | Function and homology information proteasome core complex assembly / nuclear outer membrane-endoplasmic reticulum membrane network / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / proteasomal ubiquitin-independent protein catabolic process / Ubiquitin Mediated Degradation of Phosphorylated Cdc25A / Regulation of PTEN stability and activity / KEAP1-NFE2L2 pathway / CDK-mediated phosphorylation and removal of Cdc6 / Neddylation ...proteasome core complex assembly / nuclear outer membrane-endoplasmic reticulum membrane network / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / proteasomal ubiquitin-independent protein catabolic process / Ubiquitin Mediated Degradation of Phosphorylated Cdc25A / Regulation of PTEN stability and activity / KEAP1-NFE2L2 pathway / CDK-mediated phosphorylation and removal of Cdc6 / Neddylation / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / Orc1 removal from chromatin / MAPK6/MAPK4 signaling / proteasome storage granule / Antigen processing: Ubiquitination & Proteasome degradation / endopeptidase activator activity / proteasome assembly / proteasome endopeptidase complex / proteasome core complex, beta-subunit complex / proteasome core complex, alpha-subunit complex / threonine-type endopeptidase activity / Ub-specific processing proteases / Neutrophil degranulation / proteasome complex / proteasome-mediated ubiquitin-dependent protein catabolic process / endopeptidase activity / mRNA binding / endoplasmic reticulum membrane / mitochondrion / nucleus / cytosol Similarity search - Function | ||||||
Biological species | Saccharomyces cerevisiae (brewer's yeast) synthetic construct (others) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.7 Å | ||||||
Authors | Rostankowski, R. / Witkowska, J. / Borek, D. / Otwinowski, Z. / Jankowska, E. | ||||||
Funding support | Poland, 1items
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Citation | Journal: To Be Published Title: Crystal structures revealed the common place of binding of low-molecular mass activators with the 20S proteasome Authors: Witkowska, J. / Rostankowski, R. / Dubin, G. / Grudnik, P. / Golik, P. / Gaczynska, M. / Osmulski, P. / Borek, D. / Otwinowski, Z. / Jankowska, E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 4x6z.cif.gz | 2.4 MB | Display | PDBx/mmCIF format |
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PDB format | pdb4x6z.ent.gz | 2 MB | Display | PDB format |
PDBx/mmJSON format | 4x6z.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 4x6z_validation.pdf.gz | 704.8 KB | Display | wwPDB validaton report |
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Full document | 4x6z_full_validation.pdf.gz | 781.6 KB | Display | |
Data in XML | 4x6z_validation.xml.gz | 215.2 KB | Display | |
Data in CIF | 4x6z_validation.cif.gz | 294.2 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/x6/4x6z ftp://data.pdbj.org/pub/pdb/validation_reports/x6/4x6z | HTTPS FTP |
-Related structure data
Related structure data | 1rypS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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