Entry Database : PDB / ID : 4x3i Structure visualization Downloads & linksTitle The crystal structure of Arc N-lobe complexed with CAMK2A fragment ComponentsActivity-regulated cytoskeleton-associated protein CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE II SUBUNIT ALPHA DetailsKeywords SIGNALING PROTEIN / ENDOCYTOSIS MEDIATORFunction / homology Function and homology informationFunction Domain/homology Component
postsynaptic endosome / regulation of synaptic vesicle docking / glutamatergic postsynaptic density / HSF1-dependent transactivation / Interferon gamma signaling / Ion transport by P-type ATPases / vesicle-mediated intercellular transport / Unblocking of NMDA receptors, glutamate binding and activation / peptidyl-threonine autophosphorylation / Trafficking of AMPA receptors ... postsynaptic endosome / regulation of synaptic vesicle docking / glutamatergic postsynaptic density / HSF1-dependent transactivation / Interferon gamma signaling / Ion transport by P-type ATPases / vesicle-mediated intercellular transport / Unblocking of NMDA receptors, glutamate binding and activation / peptidyl-threonine autophosphorylation / Trafficking of AMPA receptors / RAF activation / regulation of endocannabinoid signaling pathway / neurotransmitter receptor transport to plasma membrane / neuronal ribonucleoprotein granule / : / calcium- and calmodulin-dependent protein kinase complex / Ca2+ pathway / RAF/MAP kinase cascade / regulation of neuron migration / Ca2+/calmodulin-dependent protein kinase / regulation of neurotransmitter secretion / clathrin-coated vesicle membrane / dendritic spine development / calcium-dependent protein serine/threonine kinase activity / endoderm development / Ion homeostasis / regulation of dendritic spine morphogenesis / positive regulation of calcium ion transport / presynaptic cytosol / negative regulation of hydrolase activity / postsynaptic neurotransmitter receptor diffusion trapping / regulation of cell morphogenesis / response to morphine / regulation of postsynaptic neurotransmitter receptor internalization / postsynaptic specialization membrane / GTPase activating protein binding / regulation of long-term synaptic potentiation / positive regulation of AMPA receptor activity / NMDA selective glutamate receptor signaling pathway / dendrite morphogenesis / regulation of mitochondrial membrane permeability involved in apoptotic process / regulation of neurotransmitter receptor localization to postsynaptic specialization membrane / postsynaptic cytosol / anterior/posterior pattern specification / calcium/calmodulin-dependent protein kinase activity / regulation of long-term synaptic depression / positive regulation of cardiac muscle cell apoptotic process / regulation of neuronal synaptic plasticity / mRNA transport / cellular response to interferon-beta / regulation of protein localization to plasma membrane / glutamate receptor binding / long-term memory / cytoskeleton organization / ionotropic glutamate receptor signaling pathway / dendrite cytoplasm / acrosomal vesicle / learning / response to ischemia / postsynaptic density membrane / positive regulation of receptor signaling pathway via JAK-STAT / Schaffer collateral - CA1 synapse / modulation of chemical synaptic transmission / protein homooligomerization / G1/S transition of mitotic cell cycle / endocytosis / calcium ion transport / extracellular vesicle / cell migration / actin cytoskeleton / cell cortex / early endosome membrane / peptidyl-serine phosphorylation / response to ethanol / dendritic spine / postsynaptic density / calmodulin binding / neuron projection / membrane raft / axon / protein serine kinase activity / protein serine/threonine kinase activity / mRNA binding / neuronal cell body / glutamatergic synapse / synapse / dendrite / mitochondrion / ATP binding / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function : / Activity-regulated cytoskeleton-associated protein, capsid domain / Activity-regulated cytoskeleton-associated protein, N-terminal domain / Arc MA domain / Activity-regulated cytoskeleton-associated protein / Activity-regulated cytoskeleton-associated protein, C-terminal domain / Arc C-lobe / Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / NTF2-like domain superfamily ... : / Activity-regulated cytoskeleton-associated protein, capsid domain / Activity-regulated cytoskeleton-associated protein, N-terminal domain / Arc MA domain / Activity-regulated cytoskeleton-associated protein / Activity-regulated cytoskeleton-associated protein, C-terminal domain / Arc C-lobe / Calcium/calmodulin-dependent protein kinase II, association-domain / Calcium/calmodulin dependent protein kinase II association domain / NTF2-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology Calcium/calmodulin-dependent protein kinase type II subunit alpha / Activity-regulated cytoskeleton-associated protein Similarity search - ComponentBiological species Rattus norvegicus (Norway rat)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 1.8 Å DetailsAuthors Zhang, W. / Ward, M. / Leahy, D. / Worley, P. CitationJournal : Neuron / Year : 2015Title : Structural basis of arc binding to synaptic proteins: implications for cognitive disease.Authors : Zhang, W. / Wu, J. / Ward, M.D. / Yang, S. / Chuang, Y.A. / Xiao, M. / Li, R. / Leahy, D.J. / Worley, P.F. History Deposition Nov 30, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jun 3, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Sep 27, 2017 Group : Data collection / Database references ... Data collection / Database references / Source and taxonomy / Structure summary Category : citation / diffrn_detector ... citation / diffrn_detector / entity_src_gen / struct_keywords Item : _citation.journal_id_CSD / _diffrn_detector.detector ... _citation.journal_id_CSD / _diffrn_detector.detector / _entity_src_gen.pdbx_alt_source_flag / _struct_keywords.text
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