登録情報 | データベース: PDB / ID: 4wy4 |
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タイトル | Crystal structure of autophagic SNARE complex |
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要素 | - (Synaptosomal-associated protein 29) x 2
- Syntaxin-17
- Vesicle-associated membrane protein 8
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キーワード | MEMBRANE PROTEIN / autophagy / SNARE / fusion |
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機能・相同性 | 機能・相同性情報
endoplasmic reticulum-Golgi intermediate compartment organization / mucin granule / negative regulation of secretion by cell / ciliary pocket membrane / positive regulation of histamine secretion by mast cell / smooth endoplasmic reticulum membrane / vesicle targeting / trans-Golgi Network Vesicle Budding / synaptic vesicle fusion to presynaptic active zone membrane / mitochondria-associated endoplasmic reticulum membrane contact site ...endoplasmic reticulum-Golgi intermediate compartment organization / mucin granule / negative regulation of secretion by cell / ciliary pocket membrane / positive regulation of histamine secretion by mast cell / smooth endoplasmic reticulum membrane / vesicle targeting / trans-Golgi Network Vesicle Budding / synaptic vesicle fusion to presynaptic active zone membrane / mitochondria-associated endoplasmic reticulum membrane contact site / Intra-Golgi traffic / mucus secretion / vesicle fusion / vesicle docking / chloride channel inhibitor activity / SNARE complex / SNAP receptor activity / protein localization to phagophore assembly site / syntaxin binding / COPII-mediated vesicle transport / SNARE complex assembly / synaptic vesicle priming / Lysosome Vesicle Biogenesis / azurophil granule membrane / autophagosome membrane docking / Golgi Associated Vesicle Biogenesis / COPII-coated ER to Golgi transport vesicle / Golgi organization / exocytosis / autophagosome membrane / tertiary granule membrane / autophagosome maturation / endoplasmic reticulum-Golgi intermediate compartment / autophagosome / cilium assembly / regulation of protein localization to plasma membrane / endomembrane system / endoplasmic reticulum to Golgi vesicle-mediated transport / specific granule membrane / endoplasmic reticulum-Golgi intermediate compartment membrane / SNARE binding / secretory granule membrane / intracellular protein transport / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / recycling endosome / recycling endosome membrane / phagocytic vesicle membrane / protein transport / Cargo recognition for clathrin-mediated endocytosis / late endosome membrane / Clathrin-mediated endocytosis / presynapse / ER-Phagosome pathway / early endosome membrane / protein phosphatase binding / defense response to virus / vesicle / membrane fusion / early endosome / symbiont entry into host cell / Golgi membrane / lysosomal membrane / centrosome / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / perinuclear region of cytoplasm / mitochondrion / extracellular exosome / membrane / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Syntaxin-17 / Synaptobrevin/Vesicle-associated membrane protein / Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #110 / Synaptobrevin signature. / Syntaxin / Synaptobrevin-like / Syntaxin/epimorphin, conserved site / Synaptobrevin / Syntaxin / epimorphin family signature. / v-SNARE, coiled-coil homology domain ...Syntaxin-17 / Synaptobrevin/Vesicle-associated membrane protein / Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #110 / Synaptobrevin signature. / Syntaxin / Synaptobrevin-like / Syntaxin/epimorphin, conserved site / Synaptobrevin / Syntaxin / epimorphin family signature. / v-SNARE, coiled-coil homology domain / v-SNARE coiled-coil homology domain profile. / SNARE / Helical region found in SNAREs / t-SNARE coiled-coil homology domain profile. / Target SNARE coiled-coil homology domain / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Synaptosomal-associated protein 29 / Syntaxin-17 / Vesicle-associated membrane protein 8類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 解像度: 1.4 Å |
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データ登録者 | Zhao, M. / Brunger, A.T. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | R37MH63105 | 米国 | Howard Hughes Medical Institute (HHMI) | | 米国 |
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引用 | ジャーナル: Nature / 年: 2015 タイトル: ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. 著者: Diao, J. / Liu, R. / Rong, Y. / Zhao, M. / Zhang, J. / Lai, Y. / Zhou, Q. / Wilz, L.M. / Li, J. / Vivona, S. / Pfuetzner, R.A. / Brunger, A.T. / Zhong, Q. |
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履歴 | 登録 | 2014年11月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年2月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年3月4日 | Group: Database references |
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改定 1.2 | 2015年5月6日 | Group: Database references |
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改定 1.3 | 2017年9月20日 | Group: Advisory / Author supporting evidence ...Advisory / Author supporting evidence / Database references / Derived calculations / Refinement description / Source and taxonomy / Structure summary カテゴリ: citation / entity_src_gen ...citation / entity_src_gen / pdbx_audit_support / pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / pdbx_struct_oper_list / pdbx_validate_close_contact / pdbx_validate_symm_contact / software / struct_keywords Item: _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ..._citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_assembly_prop.type / _pdbx_struct_assembly_prop.value / _pdbx_struct_oper_list.symmetry_operation / _struct_keywords.text |
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改定 1.4 | 2019年11月20日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.5 | 2024年2月28日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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