Entry Database : PDB / ID : 4wy4 Structure visualization Downloads & linksTitle Crystal structure of autophagic SNARE complex Components(Synaptosomal-associated protein 29) x 2 Syntaxin-17 Vesicle-associated membrane protein 8 DetailsKeywords MEMBRANE PROTEIN / autophagy / SNARE / fusionFunction / homology Function and homology informationFunction Domain/homology Component
endoplasmic reticulum-Golgi intermediate compartment organization / mucin granule / negative regulation of secretion by cell / ciliary pocket membrane / positive regulation of histamine secretion by mast cell / smooth endoplasmic reticulum membrane / vesicle targeting / trans-Golgi Network Vesicle Budding / synaptic vesicle fusion to presynaptic active zone membrane / mitochondria-associated endoplasmic reticulum membrane contact site ... endoplasmic reticulum-Golgi intermediate compartment organization / mucin granule / negative regulation of secretion by cell / ciliary pocket membrane / positive regulation of histamine secretion by mast cell / smooth endoplasmic reticulum membrane / vesicle targeting / trans-Golgi Network Vesicle Budding / synaptic vesicle fusion to presynaptic active zone membrane / mitochondria-associated endoplasmic reticulum membrane contact site / Intra-Golgi traffic / mucus secretion / vesicle fusion / vesicle docking / chloride channel inhibitor activity / SNARE complex / SNAP receptor activity / protein localization to phagophore assembly site / COPII-mediated vesicle transport / SNARE complex assembly / syntaxin binding / synaptic vesicle priming / azurophil granule membrane / Lysosome Vesicle Biogenesis / autophagosome membrane docking / Golgi Associated Vesicle Biogenesis / exocytosis / COPII-coated ER to Golgi transport vesicle / Golgi organization / autophagosome membrane / tertiary granule membrane / autophagosome maturation / endoplasmic reticulum-Golgi intermediate compartment / cilium assembly / autophagosome / regulation of protein localization to plasma membrane / endomembrane system / endoplasmic reticulum to Golgi vesicle-mediated transport / specific granule membrane / endoplasmic reticulum-Golgi intermediate compartment membrane / SNARE binding / secretory granule membrane / intracellular protein transport / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / recycling endosome / recycling endosome membrane / phagocytic vesicle membrane / protein transport / Cargo recognition for clathrin-mediated endocytosis / presynapse / Clathrin-mediated endocytosis / late endosome membrane / ER-Phagosome pathway / early endosome membrane / protein phosphatase binding / defense response to virus / vesicle / membrane fusion / early endosome / symbiont entry into host cell / lysosomal membrane / Golgi membrane / centrosome / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / perinuclear region of cytoplasm / mitochondrion / extracellular exosome / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function Syntaxin-17 / Synaptobrevin/Vesicle-associated membrane protein / Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #110 / Synaptobrevin signature. / Syntaxin / Synaptobrevin-like / Syntaxin/epimorphin, conserved site / Synaptobrevin / Syntaxin / epimorphin family signature. / v-SNARE, coiled-coil homology domain ... Syntaxin-17 / Synaptobrevin/Vesicle-associated membrane protein / Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #110 / Synaptobrevin signature. / Syntaxin / Synaptobrevin-like / Syntaxin/epimorphin, conserved site / Synaptobrevin / Syntaxin / epimorphin family signature. / v-SNARE, coiled-coil homology domain / v-SNARE coiled-coil homology domain profile. / SNARE / Helical region found in SNAREs / t-SNARE coiled-coil homology domain profile. / Target SNARE coiled-coil homology domain / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / Resolution : 1.4 Å DetailsAuthors Zhao, M. / Brunger, A.T. Funding support United States, 2items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of Mental Health (NIH/NIMH) R37MH63105 United States Howard Hughes Medical Institute (HHMI) United States
CitationJournal : Nature / Year : 2015Title : ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.Authors : Diao, J. / Liu, R. / Rong, Y. / Zhao, M. / Zhang, J. / Lai, Y. / Zhou, Q. / Wilz, L.M. / Li, J. / Vivona, S. / Pfuetzner, R.A. / Brunger, A.T. / Zhong, Q. History Deposition Nov 15, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 11, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Mar 4, 2015 Group : Database referencesRevision 1.2 May 6, 2015 Group : Database referencesRevision 1.3 Sep 20, 2017 Group : Advisory / Author supporting evidence ... Advisory / Author supporting evidence / Database references / Derived calculations / Refinement description / Source and taxonomy / Structure summary Category : citation / entity_src_gen ... citation / entity_src_gen / pdbx_audit_support / pdbx_struct_assembly / pdbx_struct_assembly_gen / pdbx_struct_assembly_prop / pdbx_struct_oper_list / pdbx_validate_close_contact / pdbx_validate_symm_contact / software / struct_keywords Item : _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag ... _citation.journal_id_CSD / _entity_src_gen.pdbx_alt_source_flag / _pdbx_audit_support.funding_organization / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_struct_assembly_prop.type / _pdbx_struct_assembly_prop.value / _pdbx_struct_oper_list.symmetry_operation / _struct_keywords.text Revision 1.4 Nov 20, 2019 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.5 Feb 28, 2024 Group : Data collection / Database references / Category : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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