Entry | Database: PDB / ID: 4w9x |
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Title | Crystal Structure of BMP-2-inducible kinase in complex with baricitinib |
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Components | BMP-2-inducible protein kinase |
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Keywords | TRANSFERASE / kinase / small-molecule / catalytic domain / protein binding / inhibitor / Structural Genomics / Structural Genomics Consortium / SGC |
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Function / homology | Function and homology information
phosphatase regulator activity / regulation of clathrin-dependent endocytosis / AP-2 adaptor complex binding / regulation of bone mineralization / positive regulation of Notch signaling pathway / non-specific serine/threonine protein kinase / nuclear speck / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding ...phosphatase regulator activity / regulation of clathrin-dependent endocytosis / AP-2 adaptor complex binding / regulation of bone mineralization / positive regulation of Notch signaling pathway / non-specific serine/threonine protein kinase / nuclear speck / protein serine kinase activity / protein serine/threonine kinase activity / ATP binding / nucleus / cytoplasmSimilarity search - Function BMP-2-inducible protein kinase, C-terminal / BMP-2-inducible protein kinase C-terminus / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. ...BMP-2-inducible protein kinase, C-terminal / BMP-2-inducible protein kinase C-terminus / : / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.14 Å |
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Authors | Sorrell, F.J. / Elkins, J.M. / Krojer, T. / Williams, E. / Savitsky, P. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Knapp, S. / Structural Genomics Consortium (SGC) |
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Citation | Journal: Structure / Year: 2016 Title: Family-wide Structural Analysis of Human Numb-Associated Protein Kinases. Authors: Sorrell, F.J. / Szklarz, M. / Abdul Azeez, K.R. / Elkins, J.M. / Knapp, S. |
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History | Deposition | Aug 28, 2014 | Deposition site: RCSB / Processing site: PDBE |
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Revision 1.0 | Sep 10, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 2, 2016 | Group: Database references |
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Revision 1.2 | Mar 9, 2016 | Group: Database references |
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Revision 1.3 | Jan 24, 2018 | Group: Structure summary / Category: audit_author / Item: _audit_author.name |
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Revision 1.4 | May 8, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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