Entry | Database: PDB / ID: 4uwj |
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Title | Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a capped pyrazole sulphonamide ligand |
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Components | GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE |
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Keywords | TRANSFERASE / DRUG DISCOVERY |
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Function / homology | Function and homology information
glycylpeptide N-tetradecanoyltransferase / glycylpeptide N-tetradecanoyltransferase activity / cytosol / cytoplasmSimilarity search - Function Glycylpeptide N-tetradecanoyltransferase, conserved site / Myristoyl-CoA:protein N-myristoyltransferase signature 1. / Myristoyl-CoA:protein N-myristoyltransferase signature 2. / Glycylpeptide N-tetradecanoyltransferase / Glycylpeptide N-tetradecanoyltransferase, N-terminal / Glycylpeptide N-tetradecanoyltransferase, C-terminal / Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain / Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain / Gcn5-related N-acetyltransferase (GNAT) / Acyl-CoA N-acyltransferase ...Glycylpeptide N-tetradecanoyltransferase, conserved site / Myristoyl-CoA:protein N-myristoyltransferase signature 1. / Myristoyl-CoA:protein N-myristoyltransferase signature 2. / Glycylpeptide N-tetradecanoyltransferase / Glycylpeptide N-tetradecanoyltransferase, N-terminal / Glycylpeptide N-tetradecanoyltransferase, C-terminal / Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain / Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain / Gcn5-related N-acetyltransferase (GNAT) / Acyl-CoA N-acyltransferase / Aminopeptidase / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_fungus.gif) ASPERGILLUS FUMIGATUS (mold) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.7 Å |
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Authors | Robinson, D.A. / Brand, S. / Norcross, N.R. / Thompson, S. / Harrison, J.R. / Smith, V.C. / Torrie, L.S. / McElroy, S.P. / Hallyburton, I. / Norval, S. ...Robinson, D.A. / Brand, S. / Norcross, N.R. / Thompson, S. / Harrison, J.R. / Smith, V.C. / Torrie, L.S. / McElroy, S.P. / Hallyburton, I. / Norval, S. / Stojanovski, L. / Simeons, F.R.C. / Frearson, J.A. / Brenk, R. / Fairlamb, A.H. / Ferguson, M.A.J. / Wyatt, P.G. / Gilbert, I.H. / Read, K.D. |
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Citation | Journal: J. Med. Chem. / Year: 2014 Title: Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for ...Title: Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis. Authors: Brand, S. / Norcross, N.R. / Thompson, S. / Harrison, J.R. / Smith, V.C. / Robinson, D.A. / Torrie, L.S. / McElroy, S.P. / Hallyburton, I. / Norval, S. / Scullion, P. / Stojanovski, L. / ...Authors: Brand, S. / Norcross, N.R. / Thompson, S. / Harrison, J.R. / Smith, V.C. / Robinson, D.A. / Torrie, L.S. / McElroy, S.P. / Hallyburton, I. / Norval, S. / Scullion, P. / Stojanovski, L. / Simeons, F.R. / van Aalten, D. / Frearson, J.A. / Brenk, R. / Fairlamb, A.H. / Ferguson, M.A. / Wyatt, P.G. / Gilbert, I.H. / Read, K.D. |
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History | Deposition | Aug 12, 2014 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Dec 3, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 12, 2015 | Group: Database references |
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Revision 1.2 | Jan 27, 2016 | Group: Database references |
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Revision 1.3 | Feb 14, 2018 | Group: Database references / Category: citation / citation_author Item: _citation.journal_abbrev / _citation.journal_id_ISSN ..._citation.journal_abbrev / _citation.journal_id_ISSN / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.title / _citation_author.name |
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Revision 1.4 | May 8, 2024 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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