登録情報 データベース : PDB / ID : 4tzi 構造の表示 ダウンロードとリンクタイトル Structure of unliganded Lyn SH2 domain 要素Tyrosine-protein kinase Lyn 詳細 キーワード TRANSFERASE / SH2 domain機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Platelet Adhesion to exposed collagen / Fc epsilon receptor (FCERI) signaling / Dectin-2 family / Signaling by Erythropoietin / Growth hormone receptor signaling / erythropoietin receptor binding / C-X-C chemokine receptor CXCR4 signaling pathway / regulation of monocyte chemotaxis / negative regulation of intracellular signal transduction / Fc receptor mediated stimulatory signaling pathway ... Platelet Adhesion to exposed collagen / Fc epsilon receptor (FCERI) signaling / Dectin-2 family / Signaling by Erythropoietin / Growth hormone receptor signaling / erythropoietin receptor binding / C-X-C chemokine receptor CXCR4 signaling pathway / regulation of monocyte chemotaxis / negative regulation of intracellular signal transduction / Fc receptor mediated stimulatory signaling pathway / response to sterol depletion / regulation of mast cell activation / negative regulation of myeloid leukocyte differentiation / PECAM1 interactions / CD22 mediated BCR regulation / Role of LAT2/NTAL/LAB on calcium mobilization / CD28 co-stimulation / Signaling by CSF3 (G-CSF) / CTLA4 inhibitory signaling / Erythropoietin activates RAS / eosinophil differentiation / Regulation of KIT signaling / EPHA-mediated growth cone collapse / positive regulation of Fc receptor mediated stimulatory signaling pathway / positive regulation of dendritic cell apoptotic process / positive regulation of oligodendrocyte progenitor proliferation / GPVI-mediated activation cascade / Fc receptor mediated inhibitory signaling pathway / EPH-ephrin mediated repulsion of cells / FCERI mediated MAPK activation / EPHB-mediated forward signaling / regulation of B cell receptor signaling pathway / tolerance induction to self antigen / Inactivation of CSF3 (G-CSF) signaling / integrin alpha2-beta1 complex / negative regulation of toll-like receptor 2 signaling pathway / Signaling by SCF-KIT / immune response-regulating cell surface receptor signaling pathway / FCGR activation / Cyclin D associated events in G1 / positive regulation of mast cell proliferation / negative regulation of mast cell proliferation / glycosphingolipid binding / FCERI mediated Ca+2 mobilization / Erythropoietin activates Phosphoinositide-3-kinase (PI3K) / hemoglobin biosynthetic process / phosphorylation-dependent protein binding / negative regulation of toll-like receptor 4 signaling pathway / FCERI mediated NF-kB activation / platelet degranulation / regulation of mast cell degranulation / Cell surface interactions at the vascular wall / dendritic cell differentiation / Regulation of signaling by CBL / regulation of platelet aggregation / : / regulation of B cell apoptotic process / CD209 (DC-SIGN) signaling / oligodendrocyte development / phosphatidylinositol 3-kinase activator activity / histamine secretion by mast cell / interleukin-5-mediated signaling pathway / regulation of release of sequestered calcium ion into cytosol / gamma-tubulin binding / platelet-derived growth factor receptor binding / response to carbohydrate / toll-like receptor 4 signaling pathway / postsynaptic specialization, intracellular component / negative regulation of B cell proliferation / mitochondrial crista / regulation of cell adhesion mediated by integrin / B cell homeostasis / hemopoiesis / response to axon injury / response to amino acid / hematopoietic progenitor cell differentiation / cellular response to retinoic acid / positive regulation of phosphorylation / positive regulation of glial cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / lipopolysaccharide-mediated signaling pathway / extrinsic component of cytoplasmic side of plasma membrane / regulation of cytokine production / cell surface receptor protein tyrosine kinase signaling pathway / ephrin receptor binding / erythrocyte differentiation / regulation of ERK1 and ERK2 cascade / negative regulation of protein phosphorylation / response to hormone / negative regulation of MAP kinase activity / DNA damage checkpoint signaling / mitochondrial membrane / phosphoprotein binding / adherens junction / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / response to insulin / regulation of erythrocyte differentiation / response to organic cyclic compound 類似検索 - 分子機能 Tyrosine-protein kinase Lyn, SH3 domain / Tyrosine-protein kinase Lyn, SH2 domain / SH2 domain / SHC Adaptor Protein / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains ... Tyrosine-protein kinase Lyn, SH3 domain / Tyrosine-protein kinase Lyn, SH2 domain / SH2 domain / SHC Adaptor Protein / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Mus musculus (ハツカネズミ)手法 X線回折 / 分子置換 / 解像度 : 2.1 Å 詳細データ登録者 Wybenga-Groot, L.E. 引用ジャーナル : Mol.Cell Proteomics / 年 : 2015タイトル : Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity.著者 : Jin, L.L. / Wybenga-Groot, L.E. / Tong, J. / Taylor, P. / Minden, M.D. / Trudel, S. / McGlade, C.J. / Moran, M.F. 履歴 登録 2014年7月10日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2015年1月21日 Provider : repository / タイプ : Initial release改定 1.1 2015年2月11日 Group : Database references改定 1.2 2015年4月1日 Group : Database references改定 1.3 2017年11月22日 Group : Derived calculations / Other ... Derived calculations / Other / Refinement description / Source and taxonomy カテゴリ : entity_src_gen / pdbx_database_status ... entity_src_gen / pdbx_database_status / pdbx_struct_oper_list / software Item : _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_oper_list.symmetry_operation改定 1.4 2023年9月27日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / refine_hist Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _refine_hist.number_atoms_total / _refine_hist.pdbx_number_atoms_nucleic_acid / _refine_hist.pdbx_number_atoms_protein
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