Entry Database : PDB / ID : 4rws Structure visualization Downloads & linksTitle Crystal structure of CXCR4 and viral chemokine antagonist vMIP-II complex (PSI Community Target) ComponentsC-X-C chemokine receptor type 4/Endolysin chimeric protein Viral macrophage inflammatory protein 2 DetailsKeywords SIGNALING PROTEIN / HYDROLASE / Human chemokine-chemokine receptor complex / GPCR signaling / PSI-Biology / GPCR network / membrane protein / GPCR / CXCR4 / viral antagonist chemokine vMIP-II / membrane / lipidic cubic phase / T4L / Structural GenomicsFunction / homology Function and homology informationFunction Domain/homology Component
C-X-C motif chemokine 12 receptor activity / regulation of viral process / positive regulation of vascular wound healing / positive regulation of macrophage migration inhibitory factor signaling pathway / positive regulation of mesenchymal stem cell migration / neuron recognition / response to ultrasound / response to tacrolimus / telencephalon cell migration / C-X-C chemokine receptor activity ... C-X-C motif chemokine 12 receptor activity / regulation of viral process / positive regulation of vascular wound healing / positive regulation of macrophage migration inhibitory factor signaling pathway / positive regulation of mesenchymal stem cell migration / neuron recognition / response to ultrasound / response to tacrolimus / telencephalon cell migration / C-X-C chemokine receptor activity / Specification of primordial germ cells / CXCL12-activated CXCR4 signaling pathway / myosin light chain binding / myelin maintenance / positive regulation of vasculature development / regulation of programmed cell death / CXCR chemokine receptor binding / endothelial tube morphogenesis / endothelial cell differentiation / Signaling by ROBO receptors / regulation of chemotaxis / : / positive regulation of dendrite extension / Formation of definitive endoderm / positive regulation of chemotaxis / C-C chemokine receptor activity / C-C chemokine binding / Chemokine receptors bind chemokines / chemokine activity / anchoring junction / dendritic cell chemotaxis / positive regulation of oligodendrocyte differentiation / cell leading edge / epithelial cell development / cellular response to cytokine stimulus / detection of temperature stimulus involved in sensory perception of pain / regulation of calcium ion transport / small molecule binding / Binding and entry of HIV virion / regulation of cell adhesion / coreceptor activity / detection of mechanical stimulus involved in sensory perception of pain / cardiac muscle contraction / viral release from host cell by cytolysis / peptidoglycan catabolic process / neurogenesis / cell chemotaxis / ubiquitin binding / response to activity / G protein-coupled receptor activity / calcium-mediated signaling / neuron migration / response to virus / brain development / cell wall macromolecule catabolic process / cellular response to xenobiotic stimulus / late endosome / lysozyme / lysozyme activity / virus receptor activity / positive regulation of cold-induced thermogenesis / actin binding / G alpha (i) signalling events / positive regulation of cytosolic calcium ion concentration / cytoplasmic vesicle / host cell cytoplasm / lysosome / early endosome / response to hypoxia / positive regulation of cell migration / defense response to bacterium / inflammatory response / immune response / G protein-coupled receptor signaling pathway / external side of plasma membrane / apoptotic process / ubiquitin protein ligase binding / cell surface / protein-containing complex / extracellular space / extracellular exosome / plasma membrane / cytoplasm Similarity search - Function CXC chemokine receptor 4 N-terminal domain / CXCR4 Chemokine receptor N terminal / CXC chemokine receptor 4/atypical chemokine receptor 2 / Chemokine receptor family / CC chemokine, conserved site / Small cytokines (intercrine/chemokine) C-C subfamily signature. / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily ... CXC chemokine receptor 4 N-terminal domain / CXCR4 Chemokine receptor N terminal / CXC chemokine receptor 4/atypical chemokine receptor 2 / Chemokine receptor family / CC chemokine, conserved site / Small cytokines (intercrine/chemokine) C-C subfamily signature. / Chemokine beta/gamma/delta / Intercrine alpha family (small cytokine C-X-C) (chemokine CXC). / Chemokine interleukin-8-like domain / Chemokine interleukin-8-like superfamily / Small cytokines (intecrine/chemokine), interleukin-8 like / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Lysozyme-like domain superfamily / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human) Enterobacteria phage T4 (virus) Human herpesvirus 8 strain GK18Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.1 Å DetailsAuthors Qin, L. / Kufareva, I. / Holden, L. / Wang, C. / Zheng, Y. / Wu, H. / Fenalti, G. / Han, G.W. / Cherezov, V. / Abagyan, R. ...Qin, L. / Kufareva, I. / Holden, L. / Wang, C. / Zheng, Y. / Wu, H. / Fenalti, G. / Han, G.W. / Cherezov, V. / Abagyan, R. / Stevens, R.C. / Handel, T.M. / GPCR Network (GPCR) CitationJournal : Science / Year : 2015Title : Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine.Authors : Qin, L. / Kufareva, I. / Holden, L.G. / Wang, C. / Zheng, Y. / Zhao, C. / Fenalti, G. / Wu, H. / Han, G.W. / Cherezov, V. / Abagyan, R. / Stevens, R.C. / Handel, T.M. History Deposition Dec 5, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 11, 2015 Provider : repository / Type : Initial releaseRevision 1.1 Feb 25, 2015 Group : Database referencesRevision 1.2 Apr 15, 2015 Group : Database referencesRevision 1.3 Aug 2, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.4 Nov 22, 2017 Group : Refinement description / Category : software / Item : _software.nameRevision 1.5 Sep 20, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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