登録情報 | データベース: PDB / ID: 4rch |
---|
タイトル | Discovery of 2-Pyridyl Ureas as Glucokinase Activators |
---|
要素 | Glucokinase |
---|
キーワード | TRANSFERASE |
---|
機能・相同性 | 機能・相同性情報
Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) / glucose sensor activity / mannokinase activity / regulation of potassium ion transport / hexokinase / fructokinase activity / carbohydrate phosphorylation / glucose catabolic process / glucokinase activity / glucose 6-phosphate metabolic process ...Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) / glucose sensor activity / mannokinase activity / regulation of potassium ion transport / hexokinase / fructokinase activity / carbohydrate phosphorylation / glucose catabolic process / glucokinase activity / glucose 6-phosphate metabolic process / NADP metabolic process / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / cellular response to leptin stimulus / D-glucose binding / canonical glycolysis / calcium ion import / Glycolysis / regulation of glycolytic process / intracellular glucose homeostasis / Regulation of gene expression in beta cells / positive regulation of glycogen biosynthetic process / negative regulation of gluconeogenesis / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / response to glucose / regulation of insulin secretion / glycolytic process / positive regulation of insulin secretion / cellular response to insulin stimulus / glucose metabolic process / glucose homeostasis / mitochondrion / nucleoplasm / ATP binding / cytosol類似検索 - 分子機能 Hexokinase; domain 1 / Hexokinase; domain 1 - #20 / Hexokinase / Hexokinase, binding site / Hexokinase, N-terminal / Hexokinase, C-terminal / Hexokinase / Hexokinase / Hexokinase domain signature. / Hexokinase domain profile. ...Hexokinase; domain 1 / Hexokinase; domain 1 - #20 / Hexokinase / Hexokinase, binding site / Hexokinase, N-terminal / Hexokinase, C-terminal / Hexokinase / Hexokinase / Hexokinase domain signature. / Hexokinase domain profile. / ATPase, nucleotide binding domain / ATPase, nucleotide binding domain / Nucleotidyltransferase; domain 5 / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-3LZ / alpha-D-glucopyranose / Hexokinase-4類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
---|
データ登録者 | Voegtli, W. / Vigers, G.P.A. |
---|
引用 | ジャーナル: J.Med.Chem. / 年: 2014 タイトル: Discovery of 2-pyridylureas as glucokinase activators. 著者: Hinklin, R.J. / Aicher, T.D. / Anderson, D.A. / Baer, B.R. / Boyd, S.A. / Condroski, K.R. / DeWolf, W.E. / Kraser, C.F. / McVean, M. / Rhodes, S.P. / Sturgis, H.L. / Voegtli, W.C. / Williams, L. / Houze, J.B. |
---|
履歴 | 登録 | 2014年9月16日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2014年10月8日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2014年10月22日 | Group: Database references |
---|
改定 1.2 | 2020年7月29日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_ref_seq_dif / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
---|
改定 1.3 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|