登録情報 データベース : PDB / ID : 4pk6 構造の表示 ダウンロードとリンクタイトル Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with imidazothiazole derivative 要素Indoleamine 2,3-dioxygenase 1 詳細 キーワード OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / indoleamine 2 / 3-dioxygenagse 1 / induced fit / structure based drug discovery / imidazothiazole / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response ... indoleamine 2,3-dioxygenase / smooth muscle contractile fiber / indoleamine 2,3-dioxygenase activity / positive regulation of chronic inflammatory response / kynurenic acid biosynthetic process / tryptophan 2,3-dioxygenase activity / positive regulation of T cell tolerance induction / tryptophan catabolic process to kynurenine / stereocilium bundle / positive regulation of type 2 immune response / 'de novo' NAD biosynthetic process from tryptophan / tryptophan catabolic process / Tryptophan catabolism / negative regulation of T cell apoptotic process / positive regulation of T cell apoptotic process / swimming behavior / negative regulation of interleukin-10 production / multicellular organismal response to stress / T cell proliferation / negative regulation of T cell proliferation / positive regulation of interleukin-12 production / female pregnancy / response to lipopolysaccharide / electron transfer activity / inflammatory response / heme binding / metal ion binding / cytoplasm / cytosol 類似検索 - 分子機能 Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #480 / Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase / Indoleamine 2,3-dioxygenase signature 1. / Indoleamine 2,3-dioxygenase signature 2. / Tryptophan/Indoleamine 2,3-dioxygenase-like / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 PROTOPORPHYRIN IX CONTAINING FE / Chem-PKL / Indoleamine 2,3-dioxygenase 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 3.45 Å 詳細データ登録者 Kohno, T. / Tojo, S. / Ishii, T. / Kamioka, S. 引用ジャーナル : Acs Med.Chem.Lett. / 年 : 2014タイトル : Crystal Structures and Structure-Activity Relationships of Imidazothiazole Derivatives as IDO1 Inhibitors.著者 : Tojo, S. / Kohno, T. / Tanaka, T. / Kamioka, S. / Ota, Y. / Ishii, T. / Kamimoto, K. / Asano, S. / Isobe, Y. 履歴 登録 2014年5月13日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2014年9月3日 Provider : repository / タイプ : Initial release改定 1.1 2014年10月29日 Group : Database references改定 1.2 2017年10月4日 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Other / Source and taxonomy カテゴリ : diffrn_detector / entity_src_gen ... diffrn_detector / entity_src_gen / pdbx_database_status / pdbx_struct_assembly / pdbx_struct_conn_angle / pdbx_struct_oper_list Item : _diffrn_detector.detector / _entity_src_gen.pdbx_alt_source_flag ... _diffrn_detector.detector / _entity_src_gen.pdbx_alt_source_flag / _pdbx_database_status.pdb_format_compatible / _pdbx_struct_assembly.oligomeric_details / _pdbx_struct_oper_list.symmetry_operation
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