登録情報 | データベース: PDB / ID: 4oar |
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タイトル | Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT |
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要素 | - Peptide from Nuclear receptor corepressor 2ペプチド
- Progesterone receptorプロゲステロン受容体
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キーワード | TRANSCRIPTION/Peptide / PROGESTERONE RECEPTOR (プロゲステロン受容体) / STEROID RECEPTOR / NUCLEAR RECEPTOR (核内受容体) / TRANSCRIPTION FACTOR (転写因子) / WOMEN HEALTH / CONTRACEPTION / TRANSCRIPTION-Peptide complex |
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機能・相同性 | 機能・相同性情報
glandular epithelial cell maturation / Loss of MECP2 binding ability to the NCoR/SMRT complex / tertiary branching involved in mammary gland duct morphogenesis / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / ovulation from ovarian follicle / nuclear glucocorticoid receptor binding / negative regulation of phosphorylation / 傍分泌 / maintenance of protein location in nucleus ...glandular epithelial cell maturation / Loss of MECP2 binding ability to the NCoR/SMRT complex / tertiary branching involved in mammary gland duct morphogenesis / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / ovulation from ovarian follicle / nuclear glucocorticoid receptor binding / negative regulation of phosphorylation / 傍分泌 / maintenance of protein location in nucleus / regulation of epithelial cell proliferation / Notch binding / nuclear steroid receptor activity / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / lung alveolus development / Notch-HLH transcription pathway / progesterone receptor signaling pathway / Regulation of MECP2 expression and activity / estrous cycle / estrogen response element binding / nuclear retinoid X receptor binding / intracellular steroid hormone receptor signaling pathway / Nuclear signaling by ERBB4 / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / response to organonitrogen compound / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / 授乳 / transcription repressor complex / Regulation of lipid metabolism by PPARalpha / steroid binding / cerebellum development / SUMOylation of transcription cofactors / negative regulation of miRNA transcription / G protein-coupled receptor activity / HDACs deacetylate histones / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SUMOylation of intracellular receptors / PPARA activates gene expression / Cytoprotection by HMOX1 / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / transcription coactivator binding / nuclear matrix / histone deacetylase binding / Transcriptional regulation of white adipocyte differentiation / HCMV Early Events / Nuclear Receptor transcription pathway / transcription corepressor activity / nuclear receptor activity / cell-cell signaling / response to estradiol / ATPase binding / DNA-binding transcription activator activity, RNA polymerase II-specific / Estrogen-dependent gene expression / mitochondrial outer membrane / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of gene expression / signaling receptor binding / negative regulation of DNA-templated transcription / chromatin binding / クロマチン / regulation of DNA-templated transcription / positive regulation of gene expression / regulation of transcription by RNA polymerase II / enzyme binding / negative regulation of transcription by RNA polymerase II / シグナル伝達 / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / 核質 / 生体膜 / identical protein binding / 細胞核 / 細胞膜 / 細胞質基質類似検索 - 分子機能 プロゲステロン受容体 / プロゲステロン受容体 / N-CoR, GPS2-interacting domain / G-protein pathway suppressor 2-interacting domain / SANT domain profile. / SANT domain / Myb domain / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain ...プロゲステロン受容体 / プロゲステロン受容体 / N-CoR, GPS2-interacting domain / G-protein pathway suppressor 2-interacting domain / SANT domain profile. / SANT domain / Myb domain / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Retinoid X Receptor / Retinoid X Receptor / Homeobox-like domain superfamily / 核内受容体 / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Chem-2S0 / プロゲステロン受容体 / Nuclear receptor corepressor 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.41 Å |
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データ登録者 | Petit-Topin, I. / Fay, M.R. / Resche-Rigon, M. / Ulmann, A. / Gainer, E. / Rafestin-Oblin, M.-E. / Fagart, J. |
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引用 | ジャーナル: J.Steroid Biochem.Mol.Biol. / 年: 2014 タイトル: Molecular determinants of the recognition of ulipristal acetate by oxo-steroid receptors. 著者: Petit-Topin, I. / Fay, M. / Resche-Rigon, M. / Ulmann, A. / Gainer, E. / Rafestin-Oblin, M.E. / Fagart, J. |
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履歴 | 登録 | 2014年1月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年10月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _chem_comp.name / _database_2.pdbx_DOI ..._chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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