Entry Database : PDB / ID : 4oar Structure visualization Downloads & linksTitle Progesterone receptor with bound ulipristal acetate and a peptide from the co-repressor SMRT ComponentsPeptide from Nuclear receptor corepressor 2 Progesterone receptor DetailsKeywords TRANSCRIPTION/Peptide / PROGESTERONE RECEPTOR / STEROID RECEPTOR / NUCLEAR RECEPTOR / TRANSCRIPTION FACTOR / WOMEN HEALTH / CONTRACEPTION / TRANSCRIPTION-Peptide complexFunction / homology Function and homology informationFunction Domain/homology Component
glandular epithelial cell maturation / Loss of MECP2 binding ability to the NCoR/SMRT complex / tertiary branching involved in mammary gland duct morphogenesis / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / nuclear glucocorticoid receptor binding / ovulation from ovarian follicle / paracrine signaling / regulation of epithelial cell proliferation / Notch binding ... glandular epithelial cell maturation / Loss of MECP2 binding ability to the NCoR/SMRT complex / tertiary branching involved in mammary gland duct morphogenesis / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / nuclear glucocorticoid receptor binding / ovulation from ovarian follicle / paracrine signaling / regulation of epithelial cell proliferation / Notch binding / nuclear steroid receptor activity / lung alveolus development / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / Notch-HLH transcription pathway / progesterone receptor signaling pathway / Regulation of MECP2 expression and activity / estrous cycle / estrogen response element binding / nuclear retinoid X receptor binding / intracellular steroid hormone receptor signaling pathway / Nuclear signaling by ERBB4 / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / response to organonitrogen compound / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / transcription repressor complex / lactation / steroid binding / Regulation of lipid metabolism by PPARalpha / cerebellum development / SUMOylation of transcription cofactors / negative regulation of miRNA transcription / G protein-coupled receptor activity / HDACs deacetylate histones / Downregulation of SMAD2/3:SMAD4 transcriptional activity / SUMOylation of intracellular receptors / transcription coactivator binding / PPARA activates gene expression / Cytoprotection by HMOX1 / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / nuclear matrix / Transcriptional regulation of white adipocyte differentiation / HCMV Early Events / Nuclear Receptor transcription pathway / histone deacetylase binding / transcription corepressor activity / nuclear receptor activity / response to estradiol / cell-cell signaling / ATPase binding / DNA-binding transcription activator activity, RNA polymerase II-specific / Estrogen-dependent gene expression / mitochondrial outer membrane / nucleic acid binding / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of gene expression / signaling receptor binding / negative regulation of DNA-templated transcription / chromatin binding / chromatin / positive regulation of gene expression / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / enzyme binding / signal transduction / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / membrane / identical protein binding / nucleus / plasma membrane / cytosol Similarity search - Function Progesterone receptor / Progesterone receptor / N-CoR, GPS2-interacting domain / G-protein pathway suppressor 2-interacting domain / SANT domain profile. / SANT domain / Myb domain / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain ... Progesterone receptor / Progesterone receptor / N-CoR, GPS2-interacting domain / G-protein pathway suppressor 2-interacting domain / SANT domain profile. / SANT domain / Myb domain / Myb-like DNA-binding domain / SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains / SANT/Myb domain / Retinoid X Receptor / Retinoid X Receptor / Homeobox-like domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.41 Å DetailsAuthors Petit-Topin, I. / Fay, M.R. / Resche-Rigon, M. / Ulmann, A. / Gainer, E. / Rafestin-Oblin, M.-E. / Fagart, J. CitationJournal : J.Steroid Biochem.Mol.Biol. / Year : 2014Title : Molecular determinants of the recognition of ulipristal acetate by oxo-steroid receptors.Authors : Petit-Topin, I. / Fay, M. / Resche-Rigon, M. / Ulmann, A. / Gainer, E. / Rafestin-Oblin, M.E. / Fagart, J. History Deposition Jan 6, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Oct 8, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / entity / pdbx_entity_nonpoly / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _chem_comp.name / _database_2.pdbx_DOI ... _chem_comp.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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