Entry | Database: PDB / ID: 4n9l |
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Title | crystal structure of beta-lactamse PenP_E166S in complex with meropenem |
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Components | Beta-lactamase |
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Keywords | HYDROLASE/ANTIBIOTIC / hydrolase / HYDROLASE-ANTIBIOTIC complex |
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Function / homology | Function and homology information
beta-lactam antibiotic catabolic process / beta-lactamase activity / beta-lactamase / response to antibiotic / plasma membraneSimilarity search - Function Beta-lactamase / Beta-lactamase, class-A active site / Beta-lactamase class-A active site. / Beta-lactamase class A, catalytic domain / Beta-lactamase enzyme family / Beta-lactamase, class-A / Beta-lactamase / DD-peptidase/beta-lactamase superfamily / Beta-lactamase/transpeptidase-like / Prokaryotic membrane lipoprotein lipid attachment site profile. ...Beta-lactamase / Beta-lactamase, class-A active site / Beta-lactamase class-A active site. / Beta-lactamase class A, catalytic domain / Beta-lactamase enzyme family / Beta-lactamase, class-A / Beta-lactamase / DD-peptidase/beta-lactamase superfamily / Beta-lactamase/transpeptidase-like / Prokaryotic membrane lipoprotein lipid attachment site profile. / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Bacillus licheniformis (bacteria) |
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Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.3 Å |
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Authors | Pan, X. / Wong, W. / Zhao, Y. |
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Citation | Journal: Biochemistry / Year: 2014 Title: Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Authors: Pan, X. / Wong, W. / He, Y. / Jiang, Y. / Zhao, Y. |
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History | Deposition | Oct 21, 2013 | Deposition site: RCSB / Processing site: PDBJ |
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Revision 1.0 | Sep 10, 2014 | Provider: repository / Type: Initial release |
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Revision 1.1 | Feb 9, 2022 | Group: Database references / Derived calculations / Structure summary Category: chem_comp / database_2 ...chem_comp / database_2 / entity / pdbx_entity_nonpoly / struct_conn / struct_ref_seq_dif / struct_site Item: _chem_comp.name / _chem_comp.pdbx_synonyms ..._chem_comp.name / _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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