PDB-4mz8: Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, ...

ID or keywords:

Entry

Database: PDB / ID: 4mz8

Title

Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with an Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound C91

Components

Inosine-5'-monophosphate dehydrogenase

Keywords

OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Structural Genomics / NIAID / National Institute of Allergy and Infectious Diseases / Center for Structural Genomics of Infectious Diseases / CSGID / TIM barrel / alpha-beta structure / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex

Function / homology

Function and homology information

IMP dehydrogenase / IMP dehydrogenase activity / GMP biosynthetic process / GTP biosynthetic process / nucleotide binding / metal ion binding
Similarity search - Function

Biological species

Campylobacter jejuni subsp. jejuni (Campylobacter)

Method

X-RAY DIFFRACTION /

SYNCHROTRON /

MOLECULAR REPLACEMENT / Resolution: 2.5004 Å

Authors

Kim, Y. / Makowska-Grzyska, M. / Gu, M. / Gorla, S.K. / Hedstrom, L. / Anderson, W.F. / Joachimiak, A. / CSGID / Center for Structural Genomics of Infectious Diseases (CSGID)

Citation

Journal: To be Published
Title: Crystal Structure of the Inosine 5'-monophosphate Dehydrogenase, with a Internal Deletion of CBS Domain from Campylobacter jejuni complexed with inhibitor compound C91
Authors: Kim, Y. / Makowska-Grzyska, M. / Gu, M. / Anderson, W.F. / Joachimiak, A.

History

Deposition	Sep 29, 2013	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Jul 16, 2014	Provider: repository / Type: Initial release
Revision 1.1	May 17, 2017	Group: Structure summary
Revision 1.2	Jan 24, 2018	Group: Structure summary / Category: audit_author / Item: _audit_author.name
Revision 1.3	Sep 20, 2023	Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

Structure viewer	Molecule: MolmilJmol/JSmol

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Download

PDBx/mmCIF format	4mz8.cif.gz	556.5 KB	Display	PDBx/mmCIF format
PDB format	pdb4mz8.ent.gz	463.5 KB	Display	PDB format
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Validation report

Summary document	4mz8_validation.pdf.gz	2.6 MB	Display	wwPDB validaton report
Full document	4mz8_full_validation.pdf.gz	2.7 MB	Display
Data in XML	4mz8_validation.xml.gz	55.6 KB	Display
Data in CIF	4mz8_validation.cif.gz	76.2 KB	Display
Arichive directory	https://data.pdbj.org/pub/pdb/validation_reports/mz/4mz8 ftp://data.pdbj.org/pub/pdb/validation_reports/mz/4mz8	HTTPS FTP

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Related structure data

Related structure data	4fo4S 4mz1 S: Starting model for refinement
Similar structure data	5uqg-1 4mz1-1 5uqh-2 5uqg-2 5uqf-3 5uqf-2 4r7j-1 5uqh-1 5urq-2 4mz1-2 Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Search similar-shape structures by Omokage search (details) Similarity search - Function & homologyF&H Search Similarity search - FunctionF&H Search Similarity search - HomologyF&H Search
Other databases	TargetTrack: CSGID-IDP90781

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Links

PDB pages	PDBj / wwPDB / NCBI
Related items in Molecule of the Month	#140 - Aug 2011 Rhomboid Protease GlpG similarity (4) #4 - Apr 2000 Collagen similarity (1) #116 - Aug 2009 Sulfotransferases similarity (1)

Deposited unit

A: Inosine-5'-monophosphate dehydrogenase

B: Inosine-5'-monophosphate dehydrogenase

C: Inosine-5'-monophosphate dehydrogenase

D: Inosine-5'-monophosphate dehydrogenase

hetero molecules

179 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

1

A: Inosine-5'-monophosphate dehydrogenase

B: Inosine-5'-monophosphate dehydrogenase

hetero molecules

A: Inosine-5'-monophosphate dehydrogenase

B: Inosine-5'-monophosphate dehydrogenase

hetero molecules

defined by author&software
179 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

2

C: Inosine-5'-monophosphate dehydrogenase

D: Inosine-5'-monophosphate dehydrogenase

hetero molecules

C: Inosine-5'-monophosphate dehydrogenase

D: Inosine-5'-monophosphate dehydrogenase

hetero molecules

defined by author&software
178 kDa, 4 polymers
Search similar-shape structures of this assembly by Omokage search (details)

Unit cell

Length a, b, c (Å)	114.460, 114.460, 256.314
Angle α, β, γ (deg.)	90.00, 90.00, 120.00
Int Tables number	152
Space group name H-M	P3₁21

Components on special symmetry positions

ID	Model	Components
1	1	A-508- CL
2	1	B-710- HOH

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Protein , 1 types, 4 molecules ABCD

#1: Protein	Inosine-5'-monophosphate dehydrogenase / IMP dehydrogenase / IMPD / IMPDH Mass: 43524.820 Da / Num. of mol.: 4 / Fragment: IMPDH-delta-S-CBS / Mutation: CBS domain (residues 92-195) is replaced with G Source method: isolated from a genetically manipulated source Source: (gene. exp.) Campylobacter jejuni subsp. jejuni (Campylobacter) Strain: NCTC 11168 / Gene: guaB, Cj1058c / Plasmid: pMCSG7 / Production host: Escherichia coli (E. coli) / Strain (production host): BL21 magic / References: UniProt: Q0P9J4, IMP dehydrogenase

#1: Protein

Inosine-5'-monophosphate dehydrogenase / IMP dehydrogenase / IMPD / IMPDH

Mass: 43524.820 Da / Num. of mol.: 4 / Fragment: IMPDH-delta-S-CBS / Mutation: CBS domain (residues 92-195) is replaced with G
Source method: isolated from a genetically manipulated source
Source: (gene. exp.)

Campylobacter jejuni subsp. jejuni (Campylobacter)
Strain: NCTC 11168 / Gene: guaB, Cj1058c / Plasmid: pMCSG7 / Production host:

Escherichia coli (E. coli) / Strain (production host): BL21 magic / References: UniProt: Q0P9J4, IMP dehydrogenase

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Non-polymers , 10 types, 325 molecules

#2: Chemical	ChemComp-IMP / INOSINIC ACID Mass: 348.206 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₁₀H₁₃N₄O₈P
#3: Chemical	ChemComp-C91 / N-(naphthalen-2-yl)-2-[2-(pyridin-2-yl)-1H-benzimidazol-1-yl]acetamide Mass: 378.426 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₂₄H₁₈N₄O
#4: Chemical	ChemComp-SO4 / SULFATE ION Mass: 96.063 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: SO₄
#5: Chemical	ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL Mass: 92.094 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: C₃H₈O₃
#6: Chemical	ChemComp-FMT / FORMIC ACID Mass: 46.025 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: CH₂O₂
#7: Chemical	ChemComp-ACY / ACETIC ACID Mass: 60.052 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₂H₄O₂
#8: Chemical	ChemComp-EDO / 1,2-ETHANEDIOL / ETHYLENE GLYCOL Mass: 62.068 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C₂H₆O₂
#9: Chemical	ChemComp-CL / CHLORIDE ION Mass: 35.453 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: Cl
#10: Chemical	ChemComp-2F2 / dimethyl ether Mass: 46.068 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C₂H₆O
#11: Water	ChemComp-HOH / water Mass: 18.015 Da / Num. of mol.: 294 / Source method: isolated from a natural source / Formula: H₂O

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Experiment

Experiment	Method: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

Crystal	Density Matthews: 2.95 Å³/Da / Density % sol: 58.33 %
Crystal grow	Temperature: 289 K / Method: vapor diffusion, sitting drop / pH: 6.5 Details: 1.6 M ammonium sulfate, 0.1 M MES pH 6.5, 10 % dioxane, VAPOR DIFFUSION, SITTING DROP, temperature 100K, temperature 289K

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Data collection

Diffraction	Mean temperature: 100 K
Diffraction source	Source: SYNCHROTRON / Site: APS / Beamline: 19-ID / Wavelength: 0.97926 Å
Detector	Type: ADSC QUANTUM 315r / Detector: CCD / Date: Jun 20, 2012 / Details: mirrors
Radiation	Monochromator: double crystal monochromator / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelength	Wavelength: 0.97926 Å / Relative weight: 1
Reflection	Resolution: 2.5→50 Å / Num. all: 68101 / Num. obs: 68101 / % possible obs: 99.9 % / Observed criterion σ(F): 0 / Observed criterion σ(I): 0 / Redundancy: 8.8 % / B_iso Wilson estimate: 46.46 Å² / R_sym value: 0.109 / Net I/σ(I): 10.2
Reflection shell	Resolution: 2.5→2.54 Å / Redundancy: 6.2 % / Mean I/σ(I) obs: 3 / R_sym value: 0.699 / % possible all: 99

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Processing

Software

Name	Version	Classification
SBC-Collect		data collection
HKL-3000		data collection
HKL-3000		phasing
MOLREP		phasing
PHENIX	(phenix.refine: dev_1367)	refinement
HKL-3000		data reduction
HKL-3000		data scaling

Refinement

Method to determine structure:

MOLECULAR REPLACEMENT
Starting model: PDB ENTRY 4FO4

4fo4

Resolution: 2.5004→39.231 Å / SU ML: 0.28 / Isotropic thermal model: mixed / σ(F): 1.33 / Phase error: 23.01 / Stereochemistry target values: ML

	R_factor	Num. reflection	% reflection
R_free	0.2167	3446	5.08 %
R_work	0.1756	-	-
obs	0.1777	67873	99.68 %
all	-	67873	-

Solvent computation

Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL

Displacement parameters

B_iso mean: 65.9 Å²

Refinement step

Cycle: LAST / Resolution: 2.5004→39.231 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	10444	0	296	294	11034

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.008	11031
X-RAY DIFFRACTION	f_angle_d	1.14	14898
X-RAY DIFFRACTION	f_dihedral_angle_d	15.438	4096
X-RAY DIFFRACTION	f_chiral_restr	0.068	1716
X-RAY DIFFRACTION	f_plane_restr	0.004	1891

LS refinement shell

Resolution (Å)	R_factor R_free	Num. reflection R_free	R_factor R_work	Num. reflection R_work	Refine-ID	% reflection obs (%)
2.5004-2.5346	0.3154	145	0.2502	2481	X-RAY DIFFRACTION	97
2.5346-2.5708	0.2607	110	0.2393	2537	X-RAY DIFFRACTION	99
2.5708-2.6092	0.2553	138	0.2203	2574	X-RAY DIFFRACTION	100
2.6092-2.6499	0.2708	150	0.2136	2484	X-RAY DIFFRACTION	100
2.6499-2.6934	0.2775	138	0.2207	2528	X-RAY DIFFRACTION	100
2.6934-2.7398	0.2515	134	0.2292	2553	X-RAY DIFFRACTION	100
2.7398-2.7896	0.2891	146	0.2082	2594	X-RAY DIFFRACTION	100
2.7896-2.8432	0.2536	129	0.2112	2530	X-RAY DIFFRACTION	100
2.8432-2.9013	0.2671	136	0.2107	2532	X-RAY DIFFRACTION	100
2.9013-2.9643	0.2392	118	0.1994	2599	X-RAY DIFFRACTION	100
2.9643-3.0333	0.2627	160	0.2063	2535	X-RAY DIFFRACTION	100
3.0333-3.1091	0.2576	132	0.2106	2550	X-RAY DIFFRACTION	100
3.1091-3.1931	0.2716	127	0.2017	2592	X-RAY DIFFRACTION	100
3.1931-3.287	0.2558	150	0.1875	2539	X-RAY DIFFRACTION	100
3.287-3.3931	0.2284	140	0.1871	2561	X-RAY DIFFRACTION	100
3.3931-3.5143	0.2507	130	0.1797	2577	X-RAY DIFFRACTION	100
3.5143-3.6549	0.2233	133	0.1729	2584	X-RAY DIFFRACTION	100
3.6549-3.8211	0.2321	124	0.1587	2619	X-RAY DIFFRACTION	100
3.8211-4.0223	0.2085	127	0.1504	2554	X-RAY DIFFRACTION	100
4.0223-4.2741	0.1582	139	0.1421	2604	X-RAY DIFFRACTION	100
4.2741-4.6036	0.1743	151	0.1356	2618	X-RAY DIFFRACTION	100
4.6036-5.066	0.1722	153	0.1361	2586	X-RAY DIFFRACTION	100
5.066-5.7971	0.1727	143	0.1602	2643	X-RAY DIFFRACTION	100
5.7971-7.296	0.2058	132	0.1793	2676	X-RAY DIFFRACTION	100
7.296-39.2358	0.1948	161	0.1753	2777	X-RAY DIFFRACTION	99

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°²)	L12 (°²)	L13 (°²)	L22 (°²)	L23 (°²)	L33 (°²)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å²)	T12 (Å²)	T13 (Å²)	T22 (Å²)	T23 (Å²)	T33 (Å²)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	1.6316	0.1592	-0.8334	1.1761	-0.2318	3.0316	0.0851	-0.1452	-0.227	0.2804	-0.1708	-0.011	0.2204	0.1886	0.1148	0.4835	0.028	-0.0304	0.2927	0.0687	0.2778	65.9843	-22.4843	-20.8837
2	2.1958	-0.7079	-0.8885	5.8291	0.94	4.3979	0.0307	-0.3686	-0.519	0.8487	-0.0565	-0.0924	0.9385	0.013	0.0671	0.6622	-0.0579	-0.0559	0.4451	0.1732	0.4184	63.8819	-28.5308	-7.8695
3	0.9398	0.04	-0.1	1.112	0.2169	0.6057	0.0939	-0.1978	-0.1377	0.2563	-0.1373	-0.2484	0.0256	0.2554	0.0463	0.4624	-0.007	-0.0639	0.3866	0.0968	0.2711	73.2805	-14.1541	-17.4754
4	3.1556	1.2161	1.2367	2.9444	0.676	1.9229	0.0382	-0.5378	-0.0831	0.3513	-0.1365	0.1343	-0.1693	-0.3166	0.0871	0.4213	-0.0264	0.0551	0.3405	0.0082	0.293	50.3757	-10.9199	-20.9131
5	7.3441	-2.2753	-3.2129	1.597	1.7175	3.9632	0.0536	-0.0691	-0.6695	-0.0399	-0.1668	-0.0331	0.5188	0.0859	0.1243	0.5061	0.0171	-0.0317	0.2972	0.0641	0.3364	64.056	-28.3631	-33.0378
6	3.0529	0.5183	1.6151	1.8027	-0.2785	2.082	0.0193	0.0268	-0.0919	0.0022	-0.0739	0.0108	0.0742	0.1379	0.066	0.5015	0.0705	0.0796	0.4213	0.0392	0.2583	67.091	-19.0182	-40.4866
7	1.3709	-0.9437	0.1881	2.5756	0.2472	1.1325	-0.0126	-0.1473	0.2056	0.3476	-0.0455	-0.2144	-0.298	0.153	0.0462	0.5406	-0.1684	-0.0718	0.3582	-0.0004	0.2887	65.9707	21.5693	-20.482
8	2.3928	-1.3641	0.8312	3.4751	0.365	5.5631	-0.1436	-0.4838	0.2947	0.6881	-0.0589	0.1084	-0.5831	-0.0454	0.1465	0.7137	-0.1348	-0.0532	0.4062	-0.0957	0.3653	63.6262	34.7522	-14.1729
9	1.0219	-0.1597	0.0476	0.7981	-0.0061	1.0806	0.0303	-0.1532	0.1546	0.2244	-0.0741	-0.1675	-0.2964	0.2341	0.0293	0.495	-0.1442	-0.0519	0.3009	0.0088	0.2744	68.5048	24.2195	-28.2596
10	1.3004	-0.3638	-0.1021	1.5362	-0.2137	1.4821	-0.0534	-0.1252	0.0159	0.2179	-0.0655	-0.0959	-0.0985	0.1664	0.1445	0.4422	-0.1484	-0.0572	0.3497	0.0017	0.2753	64.6579	13.1848	-24.9877
11	8.1209	2.1792	-1.8663	3.3209	2.6101	4.6263	0.1251	0.3829	0.5645	-0.3949	-0.0733	0.3022	-0.8172	-0.3301	-0.0517	0.6013	0.0083	-0.013	0.3482	0.062	0.288	54.3196	-0.7846	-25.6911
12	1.2906	0.2046	-0.1098	1.0067	-0.401	1.2725	0.0722	-0.0231	-0.0275	-0.0299	0.4577	0.8836	0.3719	-0.3922	-0.3147	0.6247	-0.1856	-0.024	0.5202	0.2946	1.114	19.0665	-31.3565	-35.19
13	1.0142	0.654	-0.6583	2.4511	0.4341	2.2182	-0.1835	0.0643	-0.4386	-0.3604	0.2233	0.4602	0.7211	-0.2475	-0.084	1.0035	-0.2791	-0.2453	0.6017	0.2741	1.1943	20.5816	-45.0227	-38.7234
14	0.0192	0.0669	-0.0537	0.136	-0.1408	0.1419	0.1103	-0.0067	-0.2125	-0.4115	0.5206	1.2792	0.5592	-0.6806	0.0154	0.7468	-0.3945	-0.4321	0.6935	0.4837	1.6852	11.2131	-28.8868	-44.9601
15	2.752	-0.7608	1.052	1.6926	-0.6069	2.8001	-0.0341	0.1633	-0.0847	-0.5845	0.1701	0.5893	0.5943	-0.0891	-0.1705	0.5134	-0.1119	-0.0774	0.3674	0.0654	0.4692	34.9843	-24.0018	-44.6786
16	5.0633	0.1498	-3.0737	0.9713	1.2176	3.6342	0.0815	-0.5453	-0.1686	0.5137	0.3372	0.7455	-0.1291	-0.3233	-0.1527	0.5438	-0.022	0.2505	0.6281	0.3572	0.9868	20.3231	-23.863	-24.5773
17	4.2176	2.0199	-0.1054	1.531	-0.2694	1.4192	0.1656	-0.1398	-0.0228	0.4179	0.3126	1.22	-0.0153	-0.4597	-0.3965	0.5402	0.078	0.2488	0.5805	0.264	1.1613	17.2819	-12.545	-28.3253
18	1.8633	-0.5801	0.1302	0.941	0.1148	0.9029	0.1215	0.0442	-0.3866	0.1375	0.1265	0.5893	-0.199	-0.1901	-0.0007	0.7952	0.2762	0.6313	0.76	0.3466	1.5868	7.7901	9.6946	-29.6255
19	0.8701	-1.1194	-0.3095	1.8665	0.1906	0.494	0.0606	-0.1484	0.2057	0.4351	0.2085	0.5155	-0.3718	-0.2244	-0.0614	1.514	0.4199	0.8546	0.7894	0.0898	0.9937	19.4243	9.8971	-8.775
20	0.3692	0.125	-0.1811	0.4658	-0.5842	0.7347	0.0556	-0.3603	0.1539	0.5373	0.0883	0.1405	-0.4396	0.2326	-0.1951	1.8063	0.2707	0.7369	0.8971	0.1389	0.7559	26.8233	-0.3037	-0.3707
21	0.9281	-0.0189	-0.708	1.4008	0.9026	1.9818	0.1355	-0.251	0.1373	0.307	-0.086	0.2104	-0.4725	-0.0805	-0.2523	1.8644	0.4172	0.8806	0.9861	0.2313	1.0517	19.4833	2.3485	1.9601
22	0.8413	0.2037	-0.4409	0.0426	-0.1082	0.2263	0.1969	-0.5552	0.0902	0.6739	0.0318	0.6128	-0.1206	-0.3369	0.0849	1.2516	0.278	0.9735	1.0405	0.4327	1.3442	9.958	-6.4703	-8.6766
23	0.0091	-0.0295	-0.0338	0.0663	0.0853	0.0816	0.0935	-0.2965	-0.2555	0.6664	0.3703	1.1643	-0.309	-0.499	-0.0728	0.8612	0.2971	0.6462	0.7919	0.3506	1.5014	12.0703	1.9148	-20.3411
24	3.6809	-1.5151	-0.18	1.9923	1.1512	0.9045	0.0492	-0.3532	0.2146	1.0667	0.3281	0.5225	-0.5166	-0.363	-0.2829	0.9506	0.1356	0.3555	0.5061	0.1013	0.5626	30.0612	3.6756	-18.714
25	2.2903	0.0601	-1.4111	0.4169	0.5913	1.8668	0.114	-0.1327	-0.0909	0.6578	0.3788	0.9686	-0.344	-0.5357	-0.3741	0.8195	0.287	0.3718	0.6893	0.3718	1.178	17.2238	14.509	-30.5015

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 'A' and (resid 1 through 86 )
2	X-RAY DIFFRACTION	2	chain 'A' and (resid 87 through 236 )
3	X-RAY DIFFRACTION	3	chain 'A' and (resid 237 through 361 )
4	X-RAY DIFFRACTION	4	chain 'A' and (resid 362 through 422 )
5	X-RAY DIFFRACTION	5	chain 'A' and (resid 423 through 441 )
6	X-RAY DIFFRACTION	6	chain 'A' and (resid 442 through 482 )
7	X-RAY DIFFRACTION	7	chain 'B' and (resid 1 through 86 )
8	X-RAY DIFFRACTION	8	chain 'B' and (resid 87 through 235 )
9	X-RAY DIFFRACTION	9	chain 'B' and (resid 236 through 382 )
10	X-RAY DIFFRACTION	10	chain 'B' and (resid 383 through 466 )
11	X-RAY DIFFRACTION	11	chain 'B' and (resid 467 through 483 )
12	X-RAY DIFFRACTION	12	chain 'C' and (resid 5 through 86 )
13	X-RAY DIFFRACTION	13	chain 'C' and (resid 87 through 236 )
14	X-RAY DIFFRACTION	14	chain 'C' and (resid 237 through 361 )
15	X-RAY DIFFRACTION	15	chain 'C' and (resid 362 through 422 )
16	X-RAY DIFFRACTION	16	chain 'C' and (resid 423 through 441 )
17	X-RAY DIFFRACTION	17	chain 'C' and (resid 442 through 482 )
18	X-RAY DIFFRACTION	18	chain 'D' and (resid 2 through 23 )
19	X-RAY DIFFRACTION	19	chain 'D' and (resid 24 through 62 )
20	X-RAY DIFFRACTION	20	chain 'D' and (resid 63 through 87 )
21	X-RAY DIFFRACTION	21	chain 'D' and (resid 88 through 236 )
22	X-RAY DIFFRACTION	22	chain 'D' and (resid 237 through 302 )
23	X-RAY DIFFRACTION	23	chain 'D' and (resid 303 through 361 )
24	X-RAY DIFFRACTION	24	chain 'D' and (resid 362 through 441 )
25	X-RAY DIFFRACTION	25	chain 'D' and (resid 442 through 482 )

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