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- PDB-4loe: Human p53 Core Domain Mutant N239Y -

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Basic information

Entry
Database: PDB / ID: 4loe
TitleHuman p53 Core Domain Mutant N239Y
ComponentsCellular tumor antigen p53
KeywordsAPOPTOSIS / Beta Sandwich / Tumor Suppressor / DNA Binding / Nuclear
Function / homology
Function and homology information


negative regulation of helicase activity / Loss of function of TP53 in cancer due to loss of tetramerization ability / Regulation of TP53 Expression / signal transduction by p53 class mediator / negative regulation of G1 to G0 transition / negative regulation of glucose catabolic process to lactate via pyruvate / Transcriptional activation of cell cycle inhibitor p21 / regulation of intrinsic apoptotic signaling pathway by p53 class mediator / negative regulation of pentose-phosphate shunt / ATP-dependent DNA/DNA annealing activity ...negative regulation of helicase activity / Loss of function of TP53 in cancer due to loss of tetramerization ability / Regulation of TP53 Expression / signal transduction by p53 class mediator / negative regulation of G1 to G0 transition / negative regulation of glucose catabolic process to lactate via pyruvate / Transcriptional activation of cell cycle inhibitor p21 / regulation of intrinsic apoptotic signaling pathway by p53 class mediator / negative regulation of pentose-phosphate shunt / ATP-dependent DNA/DNA annealing activity / Activation of NOXA and translocation to mitochondria / regulation of cell cycle G2/M phase transition / oligodendrocyte apoptotic process / negative regulation of miRNA processing / intrinsic apoptotic signaling pathway in response to hypoxia / regulation of fibroblast apoptotic process / positive regulation of thymocyte apoptotic process / oxidative stress-induced premature senescence / regulation of tissue remodeling / positive regulation of mitochondrial membrane permeability / mRNA transcription / bone marrow development / positive regulation of programmed necrotic cell death / circadian behavior / T cell proliferation involved in immune response / regulation of mitochondrial membrane permeability involved in apoptotic process / germ cell nucleus / RUNX3 regulates CDKN1A transcription / glucose catabolic process to lactate via pyruvate / TP53 Regulates Transcription of Death Receptors and Ligands / Activation of PUMA and translocation to mitochondria / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / regulation of DNA damage response, signal transduction by p53 class mediator / histone deacetylase regulator activity / negative regulation of glial cell proliferation / Regulation of TP53 Activity through Association with Co-factors / negative regulation of neuroblast proliferation / mitochondrial DNA repair / T cell lineage commitment / Formation of Senescence-Associated Heterochromatin Foci (SAHF) / ER overload response / thymocyte apoptotic process / B cell lineage commitment / TP53 Regulates Transcription of Caspase Activators and Caspases / cardiac septum morphogenesis / negative regulation of mitophagy / negative regulation of DNA replication / entrainment of circadian clock by photoperiod / negative regulation of telomere maintenance via telomerase / Zygotic genome activation (ZGA) / positive regulation of release of cytochrome c from mitochondria / PI5P Regulates TP53 Acetylation / Association of TriC/CCT with target proteins during biosynthesis / necroptotic process / TP53 Regulates Transcription of Genes Involved in Cytochrome C Release / TFIID-class transcription factor complex binding / SUMOylation of transcription factors / TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain / intrinsic apoptotic signaling pathway by p53 class mediator / rRNA transcription / negative regulation of reactive oxygen species metabolic process / Transcriptional Regulation by VENTX / cellular response to UV-C / replicative senescence / general transcription initiation factor binding / cellular response to actinomycin D / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / positive regulation of RNA polymerase II transcription preinitiation complex assembly / neuroblast proliferation / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / positive regulation of execution phase of apoptosis / viral process / Pyroptosis / hematopoietic stem cell differentiation / response to X-ray / embryonic organ development / chromosome organization / type II interferon-mediated signaling pathway / somitogenesis / TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest / hematopoietic progenitor cell differentiation / glial cell proliferation / negative regulation of fibroblast proliferation / positive regulation of cardiac muscle cell apoptotic process / core promoter sequence-specific DNA binding / negative regulation of stem cell proliferation / cellular response to glucose starvation / mitophagy / cis-regulatory region sequence-specific DNA binding / positive regulation of intrinsic apoptotic signaling pathway / Regulation of TP53 Activity through Acetylation / gastrulation / response to salt stress / 14-3-3 protein binding / mitotic G1 DNA damage checkpoint signaling / negative regulation of proteolysis / MDM2/MDM4 family protein binding / cardiac muscle cell apoptotic process / transcription repressor complex / intrinsic apoptotic signaling pathway
Similarity search - Function
Immunoglobulin-like - #720 / Cellular tumor antigen p53, transactivation domain 2 / Transactivation domain 2 / p53 transactivation domain / P53 transactivation motif / p53 family signature. / p53, tetramerisation domain / P53 tetramerisation motif / p53, DNA-binding domain / P53 DNA-binding domain ...Immunoglobulin-like - #720 / Cellular tumor antigen p53, transactivation domain 2 / Transactivation domain 2 / p53 transactivation domain / P53 transactivation motif / p53 family signature. / p53, tetramerisation domain / P53 tetramerisation motif / p53, DNA-binding domain / P53 DNA-binding domain / p53 tumour suppressor family / p53-like tetramerisation domain superfamily / p53/RUNT-type transcription factor, DNA-binding domain superfamily / p53-like transcription factor, DNA-binding / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
Cellular tumor antigen p53
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.85 Å
AuthorsWallentine, B.D. / Wang, Y. / Luecke, H.
CitationJournal: Acta Crystallogr.,Sect.D / Year: 2013
Title: Structures of oncogenic, suppressor and rescued p53 core-domain variants: mechanisms of mutant p53 rescue.
Authors: Wallentine, B.D. / Wang, Y. / Tretyachenko-Ladokhina, V. / Tan, M. / Senear, D.F. / Luecke, H.
History
DepositionJul 12, 2013Deposition site: RCSB / Processing site: RCSB
SupersessionJul 31, 2013ID: 2QXC
Revision 1.0Jul 31, 2013Provider: repository / Type: Initial release
Revision 1.1Oct 2, 2013Group: Database references
Revision 1.2Jan 15, 2014Group: Database references
Revision 1.3Jul 17, 2019Group: Data collection / Refinement description / Category: software
Item: _software.classification / _software.name / _software.version
Revision 1.4Sep 20, 2023Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Cellular tumor antigen p53
B: Cellular tumor antigen p53
C: Cellular tumor antigen p53
D: Cellular tumor antigen p53
hetero molecules


Theoretical massNumber of molelcules
Total (without water)98,8058
Polymers98,5444
Non-polymers2624
Water9,620534
1
A: Cellular tumor antigen p53
hetero molecules


Theoretical massNumber of molelcules
Total (without water)24,7012
Polymers24,6361
Non-polymers651
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
2
B: Cellular tumor antigen p53
hetero molecules


Theoretical massNumber of molelcules
Total (without water)24,7012
Polymers24,6361
Non-polymers651
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
3
C: Cellular tumor antigen p53
hetero molecules


Theoretical massNumber of molelcules
Total (without water)24,7012
Polymers24,6361
Non-polymers651
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
4
D: Cellular tumor antigen p53
hetero molecules


Theoretical massNumber of molelcules
Total (without water)24,7012
Polymers24,6361
Non-polymers651
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
MethodPISA
Unit cell
Length a, b, c (Å)68.877, 71.103, 84.302
Angle α, β, γ (deg.)90.00, 90.14, 90.00
Int Tables number4
Space group name H-MP1211

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Components

#1: Protein
Cellular tumor antigen p53 / Antigen NY-CO-13 / Phosphoprotein p53 / Tumor suppressor p53


Mass: 24635.949 Da / Num. of mol.: 4 / Fragment: p53 Core Domain (UNP residues 94-312) / Mutation: N239Y
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: P53, TP53 / Plasmid: Pse420 / Production host: Escherichia coli (E. coli) / Strain (production host): BL21(DE3) / References: UniProt: P04637
#2: Chemical
ChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 4 / Source method: obtained synthetically / Formula: Zn
#3: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 534 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.09 Å3/Da / Density % sol: 41.28 %
Crystal growTemperature: 277 K / Method: vapor diffusion, sitting drop / pH: 7.6
Details: 2 microliter protein solution (around 5.0-7.0 mg/ml protein in 20 mM Tris pH 7.6, 150 mM NaCl, 10 mM DTT) were mixed with 2 microliter reservoir buffer(200 mM lithium acetate, 20% (w/v) PEG ...Details: 2 microliter protein solution (around 5.0-7.0 mg/ml protein in 20 mM Tris pH 7.6, 150 mM NaCl, 10 mM DTT) were mixed with 2 microliter reservoir buffer(200 mM lithium acetate, 20% (w/v) PEG 3350), VAPOR DIFFUSION, SITTING DROP, temperature 277K

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Data collection

DiffractionMean temperature: 100 K
Diffraction sourceSource: SYNCHROTRON / Site: SSRL / Beamline: BL1-5 / Wavelength: 1.5418 Å
DetectorDetector: CCD / Date: Jun 6, 2006
Details: Double-crystal monochromator, 1m long Rh coated bent cylindrical mirror for horizontal and vertical focussing
RadiationMonochromator: DOUBLE CRYSTAL, PARALLEL / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1.5418 Å / Relative weight: 1
ReflectionResolution: 1.85→42.7 Å / Num. obs: 68919 / % possible obs: 98.9 % / Redundancy: 3.57 % / Rsym value: 0.084 / Net I/σ(I): 8.6
Reflection shellResolution: 1.85→1.92 Å / Mean I/σ(I) obs: 2.6 / % possible all: 97.9

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Processing

Software
NameVersionClassification
PHENIX(phenix.refine: 1.8.2_1309)refinement
CNSrefinement
Blu-Icedata collection
d*TREKdata reduction
d*TREKdata scaling
CNSphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB entry 2OCJ

2ocj


Resolution: 1.85→29.111 Å / SU ML: 0.27 / σ(F): 1.35 / Phase error: 27.49 / Stereochemistry target values: ML
RfactorNum. reflection% reflectionSelection details
Rfree0.2443 1986 2.88 %Random
Rwork0.1861 ---
obs0.1877 68855 98.31 %-
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 23.24 Å2
Refinement stepCycle: LAST / Resolution: 1.85→29.111 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6108 0 4 534 6646
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.0076290
X-RAY DIFFRACTIONf_angle_d1.0578543
X-RAY DIFFRACTIONf_dihedral_angle_d12.8182403
X-RAY DIFFRACTIONf_chiral_restr0.071927
X-RAY DIFFRACTIONf_plane_restr0.0051131
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.85-1.89230.39861250.35234336X-RAY DIFFRACTION90
1.8923-1.94350.33391410.30544770X-RAY DIFFRACTION98
1.9435-2.00070.36171420.28494726X-RAY DIFFRACTION98
2.0007-2.06520.3421450.26384769X-RAY DIFFRACTION98
2.0652-2.1390.2771370.24424766X-RAY DIFFRACTION99
2.139-2.22460.30141440.22684803X-RAY DIFFRACTION99
2.2246-2.32580.27671450.21024780X-RAY DIFFRACTION99
2.3258-2.44840.26231420.20324813X-RAY DIFFRACTION99
2.4484-2.60170.24791420.20294820X-RAY DIFFRACTION99
2.6017-2.80240.28781480.19944805X-RAY DIFFRACTION100
2.8024-3.08420.25911500.18914862X-RAY DIFFRACTION100
3.0842-3.52980.23621400.16744867X-RAY DIFFRACTION100
3.5298-4.44460.18751410.13184858X-RAY DIFFRACTION99
4.4446-29.11480.15871440.12554894X-RAY DIFFRACTION98
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
15.55840.1162-2.80723.29272.99277.79930.0136-1.0187-0.77280.25890.0386-0.03090.4045-0.1579-0.0210.3161-0.0053-0.00260.59980.24730.47370.9995-9.127143.3937
27.1417-0.05631.19253.95981.24581.2227-0.1313-0.07090.25390.01460.09390.2543-0.0468-0.20160.06520.20510.006-0.01720.2893-0.00320.2145-7.42333.302428.3072
34.9854-0.58830.77791.6321-0.30544.2538-0.0525-0.8881-0.35530.27240.06660.17510.1971-0.32520.10730.20040.00670.00160.38250.07540.26552.3877-2.429538.0513
47.26171.37592.12187.862-1.9557.10110.06560.9494-0.5665-0.3873-0.2431-0.10130.09571.05760.06230.23390.08310.030.542-0.03680.312911.4253-5.128121.3914
54.48183.16281.44667.23380.96351.9883-0.25181.63240.6999-0.82550.4186-0.2979-0.39181.3161-0.13920.3398-0.0752-0.01260.73180.04250.39414.86755.044123.731
64.0697-2.8457-0.46959.73012.66455.2763-0.2537-0.4976-0.10630.29120.368-0.3858-0.03270.3204-0.09810.1916-0.0081-0.00660.42510.0190.335114.00090.504934.1695
76.24280.2835-0.76011.5916-1.03110.7670.3315-0.45760.6801-0.1661-0.4730.4484-1.0289-0.94020.09690.36840.1778-0.04030.728-0.10880.37592.83137.241743.2915
85.7373-0.98250.75862.2814-0.72593.0894-0.0279-0.0481-0.4196-0.0980.04120.06620.24230.1683-0.02580.16270.0025-0.00030.27850.00520.26982.8802-2.37530.146
96.19534.2326-5.91614.2847-6.51762.0963-0.7151.3011-0.8916-0.96790.5446-0.13180.6809-0.66430.18910.3704-0.0546-0.00860.6128-0.15810.3387-13.8565-2.326520.5644
107.0247-4.13744.2589.219-5.45648.1056-0.2371-0.3421.38950.213-0.2403-0.2953-0.70180.0260.44080.3353-0.0392-0.00740.3393-0.10240.570133.163150.922762.4896
115.6410.5291-1.29822.3213-0.78851.8656-0.17970.8743-0.0869-0.16180.0914-0.1850.03050.21120.13740.245-0.0021-0.01980.42160.04360.30841.613538.655847.0158
127.19060.01771.63373.23871.51151.66650.244-0.97690.0970.41270.0113-0.27430.23910.1655-0.18710.2347-0.0262-0.04270.3073-0.00020.264934.715937.867863.6652
133.4447-0.18151.07932.35410.87290.6892-0.02750.30221.9122-0.4776-0.1785-0.0996-0.20080.2658-0.06420.28620.0010.02480.16960.35190.70828.848651.171949.7788
143.5217-2.0074-1.279.5465.21872.90720.24911.52631.0372-0.0134-0.5161-0.249-0.167-0.36250.23820.36450.0276-0.02330.79040.27720.454922.884747.448440.2589
155.88450.12630.31086.7730.33285.75420.03690.99140.3315-0.3087-0.10.4524-0.0348-0.34170.07010.16-0.0056-0.01840.3560.04410.308319.876239.845348.8211
165.2343-0.1785-0.39322.51970.44272.9251-0.05450.87420.1152-0.1533-0.1346-0.23660.11740.18260.20780.1787-0.00680.0080.31470.03310.276530.940639.368950.1329
176.0046-0.3124-1.92592.07980.56857.93590.14750.38531.0241-0.08640.039-0.141-0.48040.1187-0.13850.19220.0094-0.06290.23640.05910.406331.763745.870954.9121
187.715-1.87890.87851.95521.56532.2495-0.24772.16821.2269-0.59180.4524-0.1089-0.83070.5505-0.2240.4529-0.07040.00961.1340.26630.557348.250244.508739.2669
194.6960.1314-0.90652.12681.5423.9604-0.1497-1.795-0.40420.56850.3696-0.09840.9302-1.15790.16920.4331-0.10430.06191.22720.10880.33544.4325-4.781188.6274
202.3613-0.75520.87992.6947-0.3981.06610.0548-0.18980.3088-0.0259-0.01460.1174-0.00140.30670.04420.21630.0274-0.00110.4927-0.00260.314-4.48422.17370.5505
215.6604-0.34211.39851.82430.49232.6501-0.0378-0.9327-0.04690.1857-0.09160.3916-0.0252-0.51730.14440.20360.00240.01460.61970.03120.28765.6277-0.327581.5465
226.0389-0.76481.79815.47932.67483.7850.08861.4244-0.1904-1.2504-0.164-1.0598-0.32550.427500.38240.08280.12760.69010.01090.4115.9809-2.949665.7016
235.2328-0.76930.29877.75510.41633.40840.24540.04530.1544-0.0629-0.3467-0.62370.00650.10550.10870.1711-0.00240.02130.3470.06880.25117.15941.343176.2571
244.8496-5.0877-2.11526.0471.44152.22150.2415-0.53020.682-0.3983-0.35790.0074-0.6434-1.1590.09550.30650.2039-0.05870.9089-0.13560.51746.278910.831882.7694
257.06580.13962.03422.9416-0.83732.74530.23860.6648-0.2036-0.6488-0.2104-0.17330.06810.0916-0.04520.25580.03850.00760.4745-0.00110.23376.4036-3.315366.9845
266.38580.56042.21031.68310.64322.55880.1593-0.8904-0.22090.1657-0.14090.0670.0527-0.66940.08090.21750.01490.03850.55310.0240.27295.6018-2.287980.004
272.06331.5982-0.15975.4015-0.58087.5909-0.07971.4348-0.98660.02220.1082-0.14830.5554-0.6108-0.08070.36240.0358-0.0420.6207-0.15680.4804-11.0285-5.74765.3619
286.5109-3.24682.2982.3383-3.59969.7841-0.2517-1.02790.47150.6180.2321-0.3756-0.87430.0647-0.05830.3628-0.02760.00080.4518-0.06020.259929.712848.18622.9375
299.1161-1.6186-2.95136.90263.14073.175-0.25060.4068-0.51210.0110.1784-0.21520.37040.40510.00470.2179-0.0066-0.02960.29130.01820.368741.017337.70776.3134
305.27820.3325-0.72221.68620.21313.69640.0033-0.2093-0.14360.0236-0.0457-0.14790.00350.17220.07470.1763-0.007-0.02260.168-0.00180.213731.842642.963911.5346
313.65240.4963-1.4992.8154.53118.9551-0.08440.76820.3453-0.5416-0.11880.7363-0.5171-0.76850.06470.36420.0507-0.09320.46260.16060.423420.083650.61590.422
326.03081.99720.08698.44390.21959.8894-0.00531.5855-0.2783-1.4205-0.16390.87020.4208-0.91260.12260.4133-0.0211-0.12320.6347-0.05740.446616.581939.957-0.2828
338.2827-2.4842-0.89922.0555-1.09927.1835-0.09950.1518-0.12210.0486-0.00730.3764-0.0435-0.38370.10560.1819-0.0352-0.00910.21950.00270.205817.190841.380911.0237
346.8316-2.94551.25484.5053-1.22974.1271-0.0239-0.3175-0.95030.0903-0.0353-0.16330.65730.0349-0.0350.3244-0.0206-0.01950.18070.07480.396828.161632.253417.3328
354.993-0.0136-0.27993.9937-1.01185.62380.14010.53320.1623-0.4266-0.18170.1015-0.1760.0230.02380.1885-0.00280.01890.25020.02360.204828.007445.69891.3705
364.5825-0.2329-0.74522.6515-1.1097.2304-0.1186-0.74340.01420.1641-0.07-0.0817-0.0653-0.3770.14360.25240.0066-0.03120.3702-0.03450.254424.209643.850619.568
373.9361-0.1563-1.74782.22891.02818.60550.3692-0.39980.13850.00470.2233-0.2158-0.38750.706-0.53470.1966-0.0255-0.00820.1886-0.00320.267432.629146.0259.45
382.84091.14532.93245.36860.88023.0531-0.28131.03561.07010.1950.18560.5201-1.15970.92880.08780.4536-0.07550.06440.46480.15460.530145.224648.3956-0.1393
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1CHAIN A AND (RESID 96:109)
2X-RAY DIFFRACTION2CHAIN A AND (RESID 110:140)
3X-RAY DIFFRACTION3CHAIN A AND (RESID 141:168)
4X-RAY DIFFRACTION4CHAIN A AND (RESID 169:180)
5X-RAY DIFFRACTION5CHAIN A AND (RESID 181:194)
6X-RAY DIFFRACTION6CHAIN A AND (RESID 195:213)
7X-RAY DIFFRACTION7CHAIN A AND (RESID 214:229)
8X-RAY DIFFRACTION8CHAIN A AND (RESID 230:277)
9X-RAY DIFFRACTION9CHAIN A AND (RESID 278:289)
10X-RAY DIFFRACTION10CHAIN B AND (RESID 96:109)
11X-RAY DIFFRACTION11CHAIN B AND (RESID 110:140)
12X-RAY DIFFRACTION12CHAIN B AND (RESID 141:155)
13X-RAY DIFFRACTION13CHAIN B AND (RESID 156:168)
14X-RAY DIFFRACTION14CHAIN B AND (RESID 169:180)
15X-RAY DIFFRACTION15CHAIN B AND (RESID 181:213)
16X-RAY DIFFRACTION16CHAIN B AND (RESID 214:250)
17X-RAY DIFFRACTION17CHAIN B AND (RESID 251:277)
18X-RAY DIFFRACTION18CHAIN B AND (RESID 278:289)
19X-RAY DIFFRACTION19CHAIN C AND (RESID 96:109)
20X-RAY DIFFRACTION20CHAIN C AND (RESID 110:140)
21X-RAY DIFFRACTION21CHAIN C AND (RESID 141:168)
22X-RAY DIFFRACTION22CHAIN C AND (RESID 169:194)
23X-RAY DIFFRACTION23CHAIN C AND (RESID 195:213)
24X-RAY DIFFRACTION24CHAIN C AND (RESID 214:229)
25X-RAY DIFFRACTION25CHAIN C AND (RESID 230:250)
26X-RAY DIFFRACTION26CHAIN C AND (RESID 251:277)
27X-RAY DIFFRACTION27CHAIN C AND (RESID 278:289)
28X-RAY DIFFRACTION28CHAIN D AND (RESID 96:109)
29X-RAY DIFFRACTION29CHAIN D AND (RESID 110:123)
30X-RAY DIFFRACTION30CHAIN D AND (RESID 124:168)
31X-RAY DIFFRACTION31CHAIN D AND (RESID 169:180)
32X-RAY DIFFRACTION32CHAIN D AND (RESID 181:194)
33X-RAY DIFFRACTION33CHAIN D AND (RESID 195:213)
34X-RAY DIFFRACTION34CHAIN D AND (RESID 214:229)
35X-RAY DIFFRACTION35CHAIN D AND (RESID 230:250)
36X-RAY DIFFRACTION36CHAIN D AND (RESID 251:263)
37X-RAY DIFFRACTION37CHAIN D AND (RESID 264:277)
38X-RAY DIFFRACTION38CHAIN D AND (RESID 278:289)

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