登録情報 | データベース: PDB / ID: 4li2 |
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タイトル | Crystal Structures of Lgr4 and its complex with R-spondin1 |
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要素 | - Leucine-rich repeat-containing G-protein coupled receptor 4
- R-spondin-1
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キーワード | Hormone Receptor/Signaling protein / LRR / Hormone Receptor-Signaling protein complex |
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機能・相同性 | 機能・相同性情報
Regulation of FZD by ubiquitination / protein-hormone receptor activity / regulation of receptor internalization / negative regulation of toll-like receptor signaling pathway / bone remodeling / negative regulation of cytokine production / bone mineralization / positive regulation of Wnt signaling pathway / Regulation of FZD by ubiquitination / G protein-coupled receptor binding ...Regulation of FZD by ubiquitination / protein-hormone receptor activity / regulation of receptor internalization / negative regulation of toll-like receptor signaling pathway / bone remodeling / negative regulation of cytokine production / bone mineralization / positive regulation of Wnt signaling pathway / Regulation of FZD by ubiquitination / G protein-coupled receptor binding / Wntシグナル経路 / osteoblast differentiation / transmembrane signaling receptor activity / positive regulation of canonical Wnt signaling pathway / rhythmic process / heparin binding / 精子形成 / positive regulation of protein phosphorylation / G protein-coupled receptor signaling pathway / signaling receptor binding / extracellular region / identical protein binding / 細胞核 / 細胞膜類似検索 - 分子機能 R-spondin, Fu-CRD domain / Furin-like repeat, cysteine-rich / Glycoprotein hormone receptor family / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 / Thrombospondin type-1 (TSP1) repeat superfamily / Thrombospondin type-1 (TSP1) repeat profile. / Thrombospondin type 1 repeats / Thrombospondin type-1 (TSP1) repeat / Leucine-rich repeats, bacterial type ...R-spondin, Fu-CRD domain / Furin-like repeat, cysteine-rich / Glycoprotein hormone receptor family / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 / Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 / Thrombospondin type-1 (TSP1) repeat superfamily / Thrombospondin type-1 (TSP1) repeat profile. / Thrombospondin type 1 repeats / Thrombospondin type-1 (TSP1) repeat / Leucine-rich repeats, bacterial type / Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) / リボヌクレアーゼインヒビター / Leucine-rich repeat, SDS22-like subfamily / Alpha-Beta Horseshoe / Furin-like repeat / Furin-like repeats / ロイシンリッチリピート / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Growth factor receptor cysteine-rich domain superfamily / ロイシンリッチリピート / Leucine-rich repeat domain superfamily / リボン / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Mainly Beta / Alpha Beta類似検索 - ドメイン・相同性 Leucine-rich repeat-containing G-protein coupled receptor 4 / R-spondin-1類似検索 - 構成要素 |
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生物種 | Xenopus tropicalis Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.19 Å |
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データ登録者 | Xu, Y. / Rajashankar, K. / Robev, D. |
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引用 | ジャーナル: Structure / 年: 2013 タイトル: Crystal structures of lgr4 and its complex with R-spondin1. 著者: Xu, K. / Xu, Y. / Rajashankar, K.R. / Robev, D. / Nikolov, D.B. |
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履歴 | 登録 | 2013年7月2日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年8月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年9月25日 | Group: Database references |
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改定 1.2 | 2017年11月15日 | Group: Refinement description / カテゴリ: software Item: _software.classification / _software.contact_author ..._software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version |
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改定 1.3 | 2023年9月20日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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