[English] 日本語
![](img/lk-miru.gif)
- PDB-4kxb: Crystal structure of human aminopeptidase A complexed with bestatin -
+
Open data
-
Basic information
Entry | Database: PDB / ID: 4kxb | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Title | Crystal structure of human aminopeptidase A complexed with bestatin | |||||||||
![]() | Glutamyl aminopeptidase | |||||||||
![]() | HYDROLASE / zinc-aminopeptidase | |||||||||
Function / homology | ![]() glutamyl aminopeptidase / glomerulus development / peptide catabolic process / brush border / metalloaminopeptidase activity / regulation of systemic arterial blood pressure by renin-angiotensin / angiotensin maturation / Metabolism of Angiotensinogen to Angiotensins / aminopeptidase activity / peptide binding ...glutamyl aminopeptidase / glomerulus development / peptide catabolic process / brush border / metalloaminopeptidase activity / regulation of systemic arterial blood pressure by renin-angiotensin / angiotensin maturation / Metabolism of Angiotensinogen to Angiotensins / aminopeptidase activity / peptide binding / regulation of blood pressure / cell migration / apical part of cell / cell-cell signaling / cytoplasmic vesicle / angiogenesis / cell population proliferation / apical plasma membrane / lysosomal membrane / external side of plasma membrane / proteolysis / extracellular space / zinc ion binding / extracellular exosome / plasma membrane / cytoplasm Similarity search - Function | |||||||||
Biological species | ![]() | |||||||||
Method | ![]() ![]() ![]() | |||||||||
![]() | Yang, Y. / Liu, C. / Lin, Y.Y. / Li, F. | |||||||||
![]() | ![]() Title: Structural insights into central hypertension regulation by human aminopeptidase a. Authors: Yang, Y. / Liu, C. / Lin, Y.L. / Li, F. | |||||||||
History |
|
-
Structure visualization
Structure viewer | Molecule: ![]() ![]() |
---|
-
Downloads & links
-
Download
PDBx/mmCIF format | ![]() | 405.4 KB | Display | ![]() |
---|---|---|---|---|
PDB format | ![]() | 336 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 2.1 MB | Display | ![]() |
---|---|---|---|---|
Full document | ![]() | 2.1 MB | Display | |
Data in XML | ![]() | 38.5 KB | Display | |
Data in CIF | ![]() | 55.7 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 4kx7C ![]() 4kx8C ![]() 4kx9C ![]() 4kxaC ![]() 4kxcC ![]() 4kxdC C: citing same article ( |
---|---|
Similar structure data |
-
Links
-
Assembly
Deposited unit | ![]()
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
Unit cell |
| |||||||||
Components on special symmetry positions |
|
-
Components
-Protein , 1 types, 1 molecules A
#1: Protein | Mass: 102719.477 Da / Num. of mol.: 1 / Fragment: UNP residues 76-957 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() |
---|
-Sugars , 3 types, 7 molecules ![](data/chem/img/NAG.gif)
#2: Polysaccharide | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Source method: isolated from a genetically manipulated source #3: Polysaccharide | #5: Sugar | ChemComp-NAG / | |
---|
-Non-polymers , 3 types, 447 molecules ![](data/chem/img/ZN.gif)
![](data/chem/img/BES.gif)
![](data/chem/img/HOH.gif)
![](data/chem/img/BES.gif)
![](data/chem/img/HOH.gif)
#4: Chemical | ChemComp-ZN / |
---|---|
#6: Chemical | ChemComp-BES / |
#7: Water | ChemComp-HOH / |
-Experimental details
-Experiment
Experiment | Method: ![]() |
---|
-
Sample preparation
Crystal | Density Matthews: 3.36 Å3/Da / Density % sol: 63.4 % |
---|---|
Crystal grow | Temperature: 277 K / Method: vapor diffusion, sitting drop / pH: 7 Details: 1.6 M sodium citrate pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 277K |
-Data collection
Diffraction source | Source: ![]() ![]() ![]() |
---|---|
Detector | Date: May 17, 2012 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Relative weight: 1 |
Reflection | Resolution: 2.4→40 Å / Num. obs: 55096 |
-
Processing
Software | Name: REFMAC / Version: 5.7.0029 / Classification: refinement | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Refinement | Method to determine structure: ![]()
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: BABINET MODEL WITH MASK | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | Biso mean: 65.42 Å2
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.4→33.73 Å
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints |
|