SIGNALING PROTEIN / REM-domain / CDC25-homology domain / Guanine Nucleotide Exchange Factor / small G-protein binding / SH3 domain binding
Function / homology
Function and homology information
regulation of Ral protein signal transduction / RAF/MAP kinase cascade / negative regulation of cardiac muscle cell apoptotic process / small GTPase-mediated signal transduction / guanyl-nucleotide exchange factor activity / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction Similarity search - Function
Son of sevenless (SoS) protein; Chain S, domain 1 / Son of sevenless (SoS) protein Chain: S domain 1 / Son of Sevenless (SoS) protein; Chain S, domain 2 / Ras guanine-nucleotide exchange factors catalytic domain / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / Ras guanine-nucleotide exchange factor, conserved site / Ras Guanine-nucleotide exchange factors domain signature. ...Son of sevenless (SoS) protein; Chain S, domain 1 / Son of sevenless (SoS) protein Chain: S domain 1 / Son of Sevenless (SoS) protein; Chain S, domain 2 / Ras guanine-nucleotide exchange factors catalytic domain / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain profile. / Ras association (RalGDS/AF-6) domain / Ras-associating (RA) domain / Ras guanine-nucleotide exchange factor, conserved site / Ras Guanine-nucleotide exchange factors domain signature. / RasGEF N-terminal motif / Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif / Ras-like guanine nucleotide exchange factor, N-terminal / Ras guanine-nucleotide exchange factors N-terminal domain profile. / Ras-like guanine nucleotide exchange factor / Ras guanine-nucleotide exchange factor, catalytic domain superfamily / Ras guanine nucleotide exchange factor domain superfamily / RasGEF domain / Ras guanine-nucleotide exchange factors catalytic domain profile. / Guanine nucleotide exchange factor for Ras-like small GTPases / Ras guanine-nucleotide exchange factors catalytic domain / Ubiquitin-like domain superfamily / Up-down Bundle / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homology
Mass: 18.015 Da / Num. of mol.: 182 / Source method: isolated from a natural source / Formula: H2O
Sequence details
THE SEQUENCE IS BASED ON AND CDNA WAS OBTAINED FROM R. M. WOLTHUIS, ET AL., RALGDS LIKE FACTOR (RLF) ...THE SEQUENCE IS BASED ON AND CDNA WAS OBTAINED FROM R. M. WOLTHUIS, ET AL., RALGDS LIKE FACTOR (RLF) IS A NOVEL RAS AND RAP 1A-ASSOCIATING PROTEIN, 13(2), 353 (1996). THE EXPERIMENTAL INFO OF UNIPROT (Q61193 RGL2_MOUSE) SHOWS 147 H -> Y, 402 M -> T IN THIS REFERENCE.
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.58 Å3/Da / Density % sol: 52.34 %
Crystal grow
Temperature: 289 K / Method: vapor diffusion, sitting drop / pH: 6.5 Details: 0.1M Bis-Tris propane, 0.2M NaNO3, 12% PEG 3350 , pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 289K
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