登録情報 | データベース: PDB / ID: 4jbv |
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タイトル | Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1268 |
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要素 | Calmodulin-domain protein kinase 1 |
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キーワード | TRANSFERASE/TRANSFERASE INHIBITOR / serine/threonine protein kinase / transferase / calcium-binding / ATP-binding / bumped kinase inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
calcium-dependent protein serine/threonine kinase activity / calcium/calmodulin-dependent protein kinase activity / calmodulin binding / intracellular signal transduction / phosphorylation / calcium ion binding / ATP binding / membrane / nucleus / cytoplasm類似検索 - 分子機能 EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 ...EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-V68 / Calmodulin-domain protein kinase 1類似検索 - 構成要素 |
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生物種 | ![](img/tx_eukaryote.gif) Toxoplasma gondii (トキソプラズマ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.95 Å |
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データ登録者 | Merritt, E.A. / Larson, E.T. |
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引用 | ジャーナル: Eur.J.Med.Chem. / 年: 2014タイトル: Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes. 著者: Vidadala, R.S. / Ojo, K.K. / Johnson, S.M. / Zhang, Z. / Leonard, S.E. / Mitra, A. / Choi, R. / Reid, M.C. / Keyloun, K.R. / Fox, A.M. / Kennedy, M. / Silver-Brace, T. / Hume, J.C. / Kappe, S. ...著者: Vidadala, R.S. / Ojo, K.K. / Johnson, S.M. / Zhang, Z. / Leonard, S.E. / Mitra, A. / Choi, R. / Reid, M.C. / Keyloun, K.R. / Fox, A.M. / Kennedy, M. / Silver-Brace, T. / Hume, J.C. / Kappe, S. / Verlinde, C.L. / Fan, E. / Merritt, E.A. / Van Voorhis, W.C. / Maly, D.J.#1: ジャーナル: Nat.Struct.Mol.Biol. / 年: 2010タイトル: Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors. 著者: Ojo, K.K. / Larson, E.T. / Keyloun, K.R. / Castaneda, L.J. / Derocher, A.E. / Inampudi, K.K. / Kim, J.E. / Arakaki, T.L. / Murphy, R.C. / Zhang, L. / Napuli, A.J. / Maly, D.J. / Verlinde, C.L. ...著者: Ojo, K.K. / Larson, E.T. / Keyloun, K.R. / Castaneda, L.J. / Derocher, A.E. / Inampudi, K.K. / Kim, J.E. / Arakaki, T.L. / Murphy, R.C. / Zhang, L. / Napuli, A.J. / Maly, D.J. / Verlinde, C.L. / Buckner, F.S. / Parsons, M. / Hol, W.G. / Merritt, E.A. / Van Voorhis, W.C. #2: ジャーナル: J.Med.Chem. / 年: 2012タイトル: Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. 著者: Larson, E.T. / Ojo, K.K. / Murphy, R.C. / Johnson, S.M. / Zhang, Z. / Kim, J.E. / Leibly, D.J. / Fox, A.M. / Reid, M.C. / Dale, E.J. / Perera, B.G. / Kim, J. / Hewitt, S.N. / Hol, W.G. / ...著者: Larson, E.T. / Ojo, K.K. / Murphy, R.C. / Johnson, S.M. / Zhang, Z. / Kim, J.E. / Leibly, D.J. / Fox, A.M. / Reid, M.C. / Dale, E.J. / Perera, B.G. / Kim, J. / Hewitt, S.N. / Hol, W.G. / Verlinde, C.L. / Fan, E. / Van Voorhis, W.C. / Maly, D.J. / Merritt, E.A. |
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履歴 | 登録 | 2013年2月20日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2014年3月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年3月26日 | Group: Non-polymer description |
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改定 1.2 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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