Interaction between PHLDA1 and AURKA / regulation of centrosome cycle / axon hillock / spindle assembly involved in female meiosis I / cilium disassembly / positive regulation of oocyte maturation / spindle pole centrosome / histone H3S10 kinase activity / chromosome passenger complex / pronucleus ...Interaction between PHLDA1 and AURKA / regulation of centrosome cycle / axon hillock / spindle assembly involved in female meiosis I / cilium disassembly / positive regulation of oocyte maturation / spindle pole centrosome / histone H3S10 kinase activity / chromosome passenger complex / pronucleus / meiotic spindle / mitotic centrosome separation / germinal vesicle / protein localization to centrosome / anterior/posterior axis specification / centrosome localization / neuron projection extension / spindle organization / positive regulation of mitochondrial fission / mitotic spindle pole / SUMOylation of DNA replication proteins / spindle midzone / regulation of G2/M transition of mitotic cell cycle / centriole / protein serine/threonine/tyrosine kinase activity / positive regulation of mitotic cell cycle / positive regulation of mitotic nuclear division / AURKA Activation by TPX2 / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / mitotic spindle organization / ciliary basal body / regulation of cytokinesis / regulation of signal transduction by p53 class mediator / negative regulation of protein binding / molecular function activator activity / liver regeneration / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 / regulation of protein stability / spindle microtubule / mitotic spindle / kinetochore / response to wounding / spindle / G2/M transition of mitotic cell cycle / microtubule cytoskeleton / Regulation of PLK1 Activity at G2/M Transition / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / mitotic cell cycle / midbody / basolateral plasma membrane / peptidyl-serine phosphorylation / proteasome-mediated ubiquitin-dependent protein catabolic process / Regulation of TP53 Activity through Phosphorylation / protein autophosphorylation / postsynaptic density / non-specific serine/threonine protein kinase / protein kinase activity / protein heterodimerization activity / cell division / protein phosphorylation / negative regulation of gene expression / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / glutamatergic synapse / apoptotic process / ubiquitin protein ligase binding / negative regulation of apoptotic process / protein kinase binding / perinuclear region of cytoplasm / nucleoplasm / ATP binding / nucleus / cytosol Similarity search - Function
Aurora kinase A / Aurora kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain ...Aurora kinase A / Aurora kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta Similarity search - Domain/homology
Resolution: 2.7→30 Å / Cor.coef. Fo:Fc: 0.936 / Cor.coef. Fo:Fc free: 0.886 / SU B: 37.516 / SU ML: 0.357 / Cross valid method: THROUGHOUT / ESU R: 1.353 / ESU R Free: 0.435 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.32296
736
7.6 %
RANDOM
Rwork
0.23165
-
-
-
obs
0.23834
8991
100 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.4 Å / Solvent model: BABINET MODEL WITH MASK
Displacement parameters
Biso mean: 84.154 Å2
Baniso -1
Baniso -2
Baniso -3
1-
-0.2 Å2
-0.1 Å2
0 Å2
2-
-
-0.2 Å2
0 Å2
3-
-
-
0.29 Å2
Refinement step
Cycle: LAST / Resolution: 2.7→30 Å
Protein
Nucleic acid
Ligand
Solvent
Total
Num. atoms
2164
0
15
10
2189
Refine LS restraints
Refine-ID
Type
Dev ideal
Dev ideal target
Number
X-RAY DIFFRACTION
r_bond_refined_d
0.024
0.021
2173
X-RAY DIFFRACTION
r_bond_other_d
0.004
0.02
1962
X-RAY DIFFRACTION
r_angle_refined_deg
2.137
1.969
2950
X-RAY DIFFRACTION
r_angle_other_deg
1.024
3
4524
X-RAY DIFFRACTION
r_dihedral_angle_1_deg
7.691
5
264
X-RAY DIFFRACTION
r_dihedral_angle_2_deg
37.011
22.871
101
X-RAY DIFFRACTION
r_dihedral_angle_3_deg
18.962
15
351
X-RAY DIFFRACTION
r_dihedral_angle_4_deg
19.915
15
17
X-RAY DIFFRACTION
r_chiral_restr
0.114
0.2
318
X-RAY DIFFRACTION
r_gen_planes_refined
0.01
0.021
2425
X-RAY DIFFRACTION
r_gen_planes_other
0.005
0.02
475
X-RAY DIFFRACTION
r_nbd_refined
X-RAY DIFFRACTION
r_nbd_other
X-RAY DIFFRACTION
r_nbtor_refined
X-RAY DIFFRACTION
r_nbtor_other
X-RAY DIFFRACTION
r_xyhbond_nbd_refined
X-RAY DIFFRACTION
r_xyhbond_nbd_other
X-RAY DIFFRACTION
r_metal_ion_refined
X-RAY DIFFRACTION
r_metal_ion_other
X-RAY DIFFRACTION
r_symmetry_vdw_refined
X-RAY DIFFRACTION
r_symmetry_vdw_other
X-RAY DIFFRACTION
r_symmetry_hbond_refined
X-RAY DIFFRACTION
r_symmetry_hbond_other
X-RAY DIFFRACTION
r_symmetry_metal_ion_refined
X-RAY DIFFRACTION
r_symmetry_metal_ion_other
X-RAY DIFFRACTION
r_mcbond_it
1.375
1.5
110
X-RAY DIFFRACTION
r_mcbond_other
0.486
1.5
51
X-RAY DIFFRACTION
r_mcangle_it
2.486
2
170
X-RAY DIFFRACTION
r_scbond_it
2.649
3
59
X-RAY DIFFRACTION
r_scangle_it
4.275
4.5
60
X-RAY DIFFRACTION
r_rigid_bond_restr
X-RAY DIFFRACTION
r_sphericity_free
X-RAY DIFFRACTION
r_sphericity_bonded
LS refinement shell
Resolution: 2.699→2.769 Å / Total num. of bins used: 20
Rfactor
Num. reflection
% reflection
Rfree
0.382
49
-
Rwork
0.356
641
-
obs
-
-
100 %
Refinement TLS params.
Method: refined / Origin x: -17.087 Å / Origin y: -32.182 Å / Origin z: 7.739 Å
11
12
13
21
22
23
31
32
33
T
0.0712 Å2
0.051 Å2
0.0132 Å2
-
0.0523 Å2
-0.0108 Å2
-
-
0.0354 Å2
L
2.7413 °2
0.6593 °2
1.1406 °2
-
1.2594 °2
0.8548 °2
-
-
0.7851 °2
S
-0.1822 Å °
-0.2992 Å °
0.2341 Å °
0.0651 Å °
0.0565 Å °
0.1042 Å °
-0.0358 Å °
-0.068 Å °
0.1256 Å °
+
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