登録情報 データベース : PDB / ID : 4ikp 構造の表示 ダウンロードとリンクタイトル Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin 要素Histone-arginine methyltransferase CARM1 詳細 キーワード TRANSFERASE / Structural Genomics / Structural Genomics Consortium / SGC機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H3R17 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / negative regulation of dendrite development / protein-arginine omega-N asymmetric methyltransferase activity / histone arginine N-methyltransferase activity / protein methyltransferase activity / regulation of intracellular estrogen receptor signaling pathway / protein-arginine N-methyltransferase activity / replication fork reversal ... histone H3R17 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / negative regulation of dendrite development / protein-arginine omega-N asymmetric methyltransferase activity / histone arginine N-methyltransferase activity / protein methyltransferase activity / regulation of intracellular estrogen receptor signaling pathway / protein-arginine N-methyltransferase activity / replication fork reversal / positive regulation of epithelial cell apoptotic process / histone methyltransferase activity / positive regulation of transcription by RNA polymerase I / nuclear replication fork / positive regulation of fat cell differentiation / response to cAMP / RORA activates gene expression / Regulation of lipid metabolism by PPARalpha / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / BMAL1:CLOCK,NPAS2 activates circadian gene expression / Activation of gene expression by SREBF (SREBP) / nuclear receptor coactivator activity / Heme signaling / lysine-acetylated histone binding / Transcriptional activation of mitochondrial biogenesis / PPARA activates gene expression / Cytoprotection by HMOX1 / RMTs methylate histone arginines / beta-catenin binding / Transcriptional regulation of white adipocyte differentiation / Circadian Clock / methylation / DNA-binding transcription factor binding / Estrogen-dependent gene expression / transcription coactivator activity / transcription cis-regulatory region binding / positive regulation of cell population proliferation / regulation of DNA-templated transcription / nucleoplasm / nucleus / cytoplasm / cytosol 類似検索 - 分子機能 Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / PH-like domain superfamily ... Histone-arginine methyltransferase CARM1, N-terminal / Coactivator-associated arginine methyltransferase 1 N terminal / Ribosomal protein L11 methyltransferase (PrmA) / Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Vaccinia Virus protein VP39 / Distorted Sandwich / PH-like domain superfamily / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性 Chem-4IK / Histone-arginine methyltransferase CARM1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Dong, A. / Dombrovski, L. / He, H. / Ibanez, G. / Wernimont, A. / Zheng, W. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / Brown, P.J. ...Dong, A. / Dombrovski, L. / He, H. / Ibanez, G. / Wernimont, A. / Zheng, W. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / Brown, P.J. / Min, J. / Luo, M. / Wu, H. / Structural Genomics Consortium (SGC) 引用ジャーナル : Elife / 年 : 2019タイトル : A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion.著者: Cai, X.C. / Zhang, T. / Kim, E.J. / Jiang, M. / Wang, K. / Wang, J. / Chen, S. / Zhang, N. / Wu, H. / Li, F. / Dela Sena, C.C. / Zeng, H. / Vivcharuk, V. / Niu, X. / Zheng, W. / Lee, J.P. / ... 著者 : Cai, X.C. / Zhang, T. / Kim, E.J. / Jiang, M. / Wang, K. / Wang, J. / Chen, S. / Zhang, N. / Wu, H. / Li, F. / Dela Sena, C.C. / Zeng, H. / Vivcharuk, V. / Niu, X. / Zheng, W. / Lee, J.P. / Chen, Y. / Barsyte, D. / Szewczyk, M. / Hajian, T. / Ibanez, G. / Dong, A. / Dombrovski, L. / Zhang, Z. / Deng, H. / Min, J. / Arrowsmith, C.H. / Mazutis, L. / Shi, L. / Vedadi, M. / Brown, P.J. / Xiang, J. / Qin, L.X. / Xu, W. / Luo, M. 履歴 登録 2012年12月27日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2013年2月13日 Provider : repository / タイプ : Initial release改定 1.1 2013年5月15日 Group : Structure summary改定 1.2 2018年1月24日 Group : Database references / Source and taxonomy / Structure summaryカテゴリ : citation / entity_src_gen / structItem : _citation.title / _entity_src_gen.host_org_common_name ... _citation.title / _entity_src_gen.host_org_common_name / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name / _entity_src_gen.pdbx_host_org_strain / _entity_src_gen.pdbx_host_org_vector_type / _entity_src_gen.plasmid_name / _struct.title 改定 1.3 2018年4月18日 Group : Data collection / Source and taxonomy / カテゴリ : entity_src_gen / Item : _entity_src_gen.pdbx_host_org_scientific_name改定 1.4 2023年8月16日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / citation_author / database_2 / struct_site Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.5 2023年9月20日 Group : Refinement description / カテゴリ : pdbx_initial_refinement_model
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