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- PDB-4iem: Human apurinic/apyrimidinic endonuclease (APE1) with product DNA ... -
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Basic information
Entry | Database: PDB / ID: 4iem | ||||||
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Title | Human apurinic/apyrimidinic endonuclease (APE1) with product DNA and Mg2+ | ||||||
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![]() | HYDROLASE / LYASE/DNA / metalloprotein / DNA damage / DNA repair / base excision repair / protein-DNA / REF1 / nuclease / LYASE-DNA complex | ||||||
Function / homology | ![]() Resolution of Abasic Sites (AP sites) / class II DNA-(apurinic or apyrimidinic site) endonuclease activity / phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands / telomere maintenance via base-excision repair / site-specific endodeoxyribonuclease activity, specific for altered base / DNA-(abasic site) binding / double-stranded DNA exodeoxyribonuclease activity / double-stranded telomeric DNA binding / phosphodiesterase I activity / double-stranded DNA 3'-5' DNA exonuclease activity ...Resolution of Abasic Sites (AP sites) / class II DNA-(apurinic or apyrimidinic site) endonuclease activity / phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands / telomere maintenance via base-excision repair / site-specific endodeoxyribonuclease activity, specific for altered base / DNA-(abasic site) binding / double-stranded DNA exodeoxyribonuclease activity / double-stranded telomeric DNA binding / phosphodiesterase I activity / double-stranded DNA 3'-5' DNA exonuclease activity / exodeoxyribonuclease III / positive regulation of gene expression via chromosomal CpG island demethylation / Displacement of DNA glycosylase by APEX1 / phosphoric diester hydrolase activity / Hydrolases; Acting on ester bonds; Endodeoxyribonucleases producing 5'-phosphomonoesters / uracil DNA N-glycosylase activity / DNA catabolic process / 3'-5'-DNA exonuclease activity / Resolution of AP sites via the multiple-nucleotide patch replacement pathway / Abasic sugar-phosphate removal via the single-nucleotide replacement pathway / POLB-Dependent Long Patch Base Excision Repair / PCNA-Dependent Long Patch Base Excision Repair / DNA-(apurinic or apyrimidinic site) endonuclease activity / regulation of mRNA stability / 3'-5' exonuclease activity / telomere maintenance / base-excision repair, gap-filling / DNA endonuclease activity / cell redox homeostasis / base-excision repair / chromatin DNA binding / transcription corepressor activity / RNA-DNA hybrid ribonuclease activity / regulation of apoptotic process / endonuclease activity / DNA recombination / chromosome, telomeric region / damaged DNA binding / oxidoreductase activity / transcription coactivator activity / ribosome / nuclear speck / DNA repair / centrosome / nucleolus / perinuclear region of cytoplasm / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / mitochondrion / DNA binding / RNA binding / nucleoplasm / nucleus / metal ion binding / cytoplasm Similarity search - Function | ||||||
Biological species | ![]() Synthetic DNA (others) | ||||||
Method | ![]() ![]() ![]() ![]() | ||||||
![]() | Tsutakawa, S.E. / Mol, C.D. / Arvai, A.S. / Tainer, J.A. | ||||||
![]() | ![]() Title: Conserved Structural Chemistry for Incision Activity in Structurally Non-homologous Apurinic/Apyrimidinic Endonuclease APE1 and Endonuclease IV DNA Repair Enzymes. Authors: Tsutakawa, S.E. / Shin, D.S. / Mol, C.D. / Izumi, T. / Arvai, A.S. / Mantha, A.K. / Szczesny, B. / Ivanov, I.N. / Hosfield, D.J. / Maiti, B. / Pique, M.E. / Frankel, K.A. / Hitomi, K. / ...Authors: Tsutakawa, S.E. / Shin, D.S. / Mol, C.D. / Izumi, T. / Arvai, A.S. / Mantha, A.K. / Szczesny, B. / Ivanov, I.N. / Hosfield, D.J. / Maiti, B. / Pique, M.E. / Frankel, K.A. / Hitomi, K. / Cunningham, R.P. / Mitra, S. / Tainer, J.A. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 493.7 KB | Display | ![]() |
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PDB format | ![]() | 403.2 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 529.8 KB | Display | ![]() |
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Full document | ![]() | 558.4 KB | Display | |
Data in XML | ![]() | 47.9 KB | Display | |
Data in CIF | ![]() | 66.1 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 4hnoC ![]() 4iek C: citing same article ( |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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