登録情報 | データベース: PDB / ID: 4ic7 |
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タイトル | Crystal structure of the ERK5 kinase domain in complex with an MKK5 binding fragment |
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要素 | - Dual specificity mitogen-activated protein kinase kinase 5
- Mitogen-activated protein kinase 7
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キーワード | TRANSFERASE / kinase domain / SIGNALING PROTEIN COMPLEX |
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機能・相同性 | 機能・相同性情報
ERK5 cascade / negative regulation of chemokine (C-X-C motif) ligand 2 production / Signalling to ERK5 / negative regulation of response to cytokine stimulus / negative regulation of heterotypic cell-cell adhesion / calcineurin-NFAT signaling cascade / negative regulation of interleukin-8 production / mitogen-activated protein kinase kinase / cellular response to laminar fluid shear stress / Gastrin-CREB signalling pathway via PKC and MAPK ...ERK5 cascade / negative regulation of chemokine (C-X-C motif) ligand 2 production / Signalling to ERK5 / negative regulation of response to cytokine stimulus / negative regulation of heterotypic cell-cell adhesion / calcineurin-NFAT signaling cascade / negative regulation of interleukin-8 production / mitogen-activated protein kinase kinase / cellular response to laminar fluid shear stress / Gastrin-CREB signalling pathway via PKC and MAPK / negative regulation of cell migration involved in sprouting angiogenesis / ERKs are inactivated / enzyme inhibitor activity / mitogen-activated protein kinase binding / negative regulation of calcineurin-NFAT signaling cascade / negative regulation of NF-kappaB transcription factor activity / ERK/MAPK targets / negative regulation of smooth muscle cell apoptotic process / MAP kinase kinase activity / RET signaling / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / MAP kinase activity / mitogen-activated protein kinase / regulation of angiogenesis / negative regulation of endothelial cell apoptotic process / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / cellular response to transforming growth factor beta stimulus / positive regulation of protein metabolic process / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / insulin-like growth factor receptor signaling pathway / positive regulation of epithelial cell proliferation / positive regulation of MAP kinase activity / adenylate cyclase-activating G protein-coupled receptor signaling pathway / PML body / cellular response to growth factor stimulus / negative regulation of inflammatory response / cellular response to hydrogen peroxide / spindle / MAPK cascade / heart development / Senescence-Associated Secretory Phenotype (SASP) / positive regulation of cell growth / protein tyrosine kinase activity / cell differentiation / protein kinase activity / intracellular signal transduction / protein serine kinase activity / protein serine/threonine kinase activity / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / nucleus / metal ion binding / cytosol / cytoplasm類似検索 - 分子機能 Dual specificity mitogen-activated protein kinase kinase 5, PB1 domain / PB1 domain / PB1 domain / PB1 domain profile. / PB1 domain / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) ...Dual specificity mitogen-activated protein kinase kinase 5, PB1 domain / PB1 domain / PB1 domain / PB1 domain profile. / PB1 domain / : / Mitogen-activated protein (MAP) kinase, conserved site / MAP kinase signature. / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / Dual specificity mitogen-activated protein kinase kinase 5 / Mitogen-activated protein kinase 7類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6 Å |
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データ登録者 | Gogl, G. / Remenyi, A. |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2013 タイトル: Structural mechanism for the specific assembly and activation of the extracellular signal regulated kinase 5 (ERK5) module. 著者: Glatz, G. / Gogl, G. / Alexa, A. / Remenyi, A. |
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履歴 | 登録 | 2012年12月10日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2013年2月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2013年8月7日 | Group: Database references |
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改定 1.2 | 2024年2月28日 | Group: Data collection / Database references / Derived calculations カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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