Entry Database : PDB / ID : 4i7c Structure visualization Downloads & linksTitle Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR ComponentsE3 ubiquitin-protein ligase SIAH1 Protein phyllopod DetailsKeywords LIGASE/LIGASE INHIBITOR / Sina / beta sandwich / zinc finger / ubiquitin ligase / covalent inhibitor / LIGASE-LIGASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
R1/R6 cell fate commitment / sensory organ boundary specification / enteroendocrine cell differentiation / R7 cell fate commitment / sensory organ precursor cell fate determination / sevenless signaling pathway / Netrin-1 signaling / sensory organ development / beta-catenin destruction complex / ubiquitin conjugating enzyme binding ... R1/R6 cell fate commitment / sensory organ boundary specification / enteroendocrine cell differentiation / R7 cell fate commitment / sensory organ precursor cell fate determination / sevenless signaling pathway / Netrin-1 signaling / sensory organ development / beta-catenin destruction complex / ubiquitin conjugating enzyme binding / negative regulation of Notch signaling pathway / ubiquitin-like ligase-substrate adaptor activity / proteasomal protein catabolic process / anatomical structure morphogenesis / canonical Wnt signaling pathway / positive regulation of intrinsic apoptotic signaling pathway / ubiquitin ligase complex / Notch signaling pathway / visual perception / axon guidance / protein catabolic process / RING-type E3 ubiquitin transferase / negative regulation of canonical Wnt signaling pathway / epidermal growth factor receptor signaling pathway / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / nervous system development / ubiquitin-dependent protein catabolic process / spermatogenesis / proteasome-mediated ubiquitin-dependent protein catabolic process / neuron apoptotic process / amyloid fibril formation / protein ubiquitination / positive regulation of apoptotic process / cell cycle / Amyloid fiber formation / apoptotic process / zinc ion binding / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function Zinc finger, AD-type / Zinc-finger associated domain (zf-AD) / : / Sina, zinc finger / E3 ubiquitin-protein ligase sina/sinah, RING finger / E3 ubiquitin-protein ligase SINA-like, animal / Seven-in-absentia protein, TRAF-like domain / Sina, TRAF-like domain / Zinc finger, SIAH-type / Zinc finger SIAH-type profile. ... Zinc finger, AD-type / Zinc-finger associated domain (zf-AD) / : / Sina, zinc finger / E3 ubiquitin-protein ligase sina/sinah, RING finger / E3 ubiquitin-protein ligase SINA-like, animal / Seven-in-absentia protein, TRAF-like domain / Sina, TRAF-like domain / Zinc finger, SIAH-type / Zinc finger SIAH-type profile. / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A / TRAF-like / Zinc/RING finger domain, C3HC4 (zinc finger) / Herpes Virus-1 / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Drosophila melanogaster (fruit fly)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Santelli, E. / Stebbins, J.L. / Feng, Y. / De, S.K. / Purves, A. / Motamedchaboki, K. / Wu, B. / Ronai, Z.A. / Liddington, R.C. / Pellecchia, M. CitationJournal : Chem.Biol. / Year : 2013Title : Structure-based design of covalent siah inhibitors.Authors : Stebbins, J.L. / Santelli, E. / Feng, Y. / De, S.K. / Purves, A. / Motamedchaboki, K. / Wu, B. / Ronai, Z.A. / Liddington, R.C. / Pellecchia, M. History Deposition Nov 30, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 14, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Sep 11, 2013 Group : Database referencesRevision 1.2 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_ptnr1_label_alt_id / _struct_conn.pdbx_ptnr2_label_alt_id / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id Revision 1.3 Dec 6, 2023 Group : Data collection / Derived calculations / Category : chem_comp_atom / chem_comp_bond / struct_connItem : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_1 ... _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_1 / _chem_comp_bond.atom_id_2 / _struct_conn.pdbx_leaving_atom_flag
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