登録情報 データベース : PDB / ID : 4i43 構造の表示 ダウンロードとリンクタイトル Crystal structure of Prp8:Aar2 complex 要素A1 cistron-splicing factor AAR2 Pre-mRNA-splicing factor 8 詳細キーワード SPLICING / spliceosome / U5 snRNP / Prp8 / Reverse Transcriptase / Aar2 / Endonuclease / RNase H / Jab1/MPN / pre-mRNA splicing機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
generation of catalytic spliceosome for second transesterification step / mRNA 5'-splice site recognition / mRNA 3'-splice site recognition / spliceosomal tri-snRNP complex assembly / U5 snRNA binding / U5 snRNP / U2 snRNA binding / U6 snRNA binding / spliceosomal snRNP assembly / pre-mRNA intronic binding ... generation of catalytic spliceosome for second transesterification step / mRNA 5'-splice site recognition / mRNA 3'-splice site recognition / spliceosomal tri-snRNP complex assembly / U5 snRNA binding / U5 snRNP / U2 snRNA binding / U6 snRNA binding / spliceosomal snRNP assembly / pre-mRNA intronic binding / U1 snRNA binding / U4/U6 x U5 tri-snRNP complex / catalytic step 2 spliceosome / spliceosomal complex / mRNA splicing, via spliceosome / metallopeptidase activity / mRNA binding / nucleus / cytoplasm 類似検索 - 分子機能 Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain / Pre-mRNA-processing-splicing factor 8 (Prp8), endonuclease domain / tt1808, chain A / Cytidine Deaminase, domain 2 / Aar2, C-terminal domain-like / Substrate Binding Domain Of DNAk; Chain A, domain 1 - #20 / Cytidine Deaminase; domain 2 / Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 / Substrate Binding Domain Of DNAk; Chain A, domain 1 / AAR2 N-terminal domain ... Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain / Pre-mRNA-processing-splicing factor 8 (Prp8), endonuclease domain / tt1808, chain A / Cytidine Deaminase, domain 2 / Aar2, C-terminal domain-like / Substrate Binding Domain Of DNAk; Chain A, domain 1 - #20 / Cytidine Deaminase; domain 2 / Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2 / Substrate Binding Domain Of DNAk; Chain A, domain 1 / AAR2 N-terminal domain / A1 cistron-splicing factor, AAR2 / AAR2, N-terminal / AAR2, C-terminal / AAR2, C-terminal domain superfamily / AAR2, N-terminal domain superfamily / AAR2 C-terminal repeat region / PROCT domain / Prp8 RNase domain IV, fingers region / PROCT (NUC072) domain / PRO8NT domain / PROCN domain / Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding / Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding / RNA recognition motif, spliceosomal PrP8 / PRP8 domain IV core / Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily / Prp8 RNase domain IV, palm region / PRO8NT (NUC069), PrP8 N-terminal domain / PROCN (NUC071) domain / U6-snRNA interacting domain of PrP8 / U5-snRNA binding site 2 of PrP8 / RNA recognition motif of the spliceosomal PrP8 / PRP8 domain IV core / Pre-mRNA-processing-splicing factor 8 / JAB/MPN domain / JAB1/MPN/MOV34 metalloenzyme domain / MPN domain / MPN domain profile. / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Ribonuclease H-like superfamily / Alpha-Beta Complex / Sandwich / 2-Layer Sandwich / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 A1 cistron-splicing factor AAR2 / Pre-mRNA-splicing factor 8 類似検索 - 構成要素生物種 Saccharomyces cerevisiae (パン酵母)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Galej, W.P. / Oubridge, C. / Newman, A.J. / Nagai, K. 引用ジャーナル : Nature / 年 : 2013タイトル : Crystal structure of Prp8 reveals active site cavity of the spliceosome.著者 : Galej, W.P. / Oubridge, C. / Newman, A.J. / Nagai, K. 履歴 登録 2012年11月27日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2013年1月23日 Provider : repository / タイプ : Initial release改定 1.1 2013年2月13日 Group : Database references改定 1.2 2018年1月24日 Group : Structure summary / カテゴリ : audit_author / Item : _audit_author.name改定 1.3 2023年9月20日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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