Entry Database : PDB / ID : 4hi8 Structure visualization Downloads & linksTitle Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800 ComponentsIntegrin-linked protein kinase LIM and senescent cell antigen-like-containing domain protein 1 DetailsKeywords SIGNALING PROTEIN / ANKYRIN REPEAT LIM DOMAIN / SIGNALING PROTEIN-SIGNALING PROTEIN COMPLEX / ILK-PINCH / Focal adhesionFunction / homology Function and homology informationFunction Domain/homology Component
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / negative regulation of neural precursor cell proliferation / positive regulation of signal transduction / positive regulation of integrin-mediated signaling pathway / nerve development / Cell-extracellular matrix interactions / fibroblast migration / myelination in peripheral nervous system / cell projection organization ... Regulation of cytoskeletal remodeling and cell spreading by IPP complex components / Localization of the PINCH-ILK-PARVIN complex to focal adhesions / negative regulation of neural precursor cell proliferation / positive regulation of signal transduction / positive regulation of integrin-mediated signaling pathway / nerve development / Cell-extracellular matrix interactions / fibroblast migration / myelination in peripheral nervous system / cell projection organization / cell-cell junction organization / positive regulation of BMP signaling pathway / neural precursor cell proliferation / establishment or maintenance of epithelial cell apical/basal polarity / positive regulation of cell-substrate adhesion / branching involved in ureteric bud morphogenesis / outflow tract morphogenesis / positive regulation of focal adhesion assembly / positive regulation of osteoblast differentiation / positive regulation of substrate adhesion-dependent cell spreading / positive regulation of phosphorylation / cellular response to transforming growth factor beta stimulus / tumor necrosis factor-mediated signaling pathway / sarcomere / phosphatidylinositol 3-kinase/protein kinase B signal transduction / substrate adhesion-dependent cell spreading / cell-matrix adhesion / positive regulation of GTPase activity / integrin-mediated signaling pathway / establishment of protein localization / cell morphogenesis / platelet aggregation / cell-cell adhesion / cell-cell junction / positive regulation of canonical Wnt signaling pathway / lamellipodium / positive regulation of canonical NF-kappaB signal transduction / non-specific serine/threonine protein kinase / positive regulation of protein phosphorylation / protein phosphorylation / protein serine kinase activity / focal adhesion / protein serine/threonine kinase activity / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / positive regulation of gene expression / protein kinase binding / positive regulation of DNA-templated transcription / perinuclear region of cytoplasm / zinc ion binding / ATP binding / membrane / plasma membrane / cytoplasm / cytosol Similarity search - Function Integrin-linked protein kinase, pseudokinase domain / : / : / Cysteine Rich Protein / Cysteine Rich Protein / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. ... Integrin-linked protein kinase, pseudokinase domain / : / : / Cysteine Rich Protein / Cysteine Rich Protein / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / Ankyrin repeat-containing domain / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Ribbon / Alpha Horseshoe / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 1.203 Å DetailsAuthors Stiegler, A.L. / Jakoncic, J. / Stojanoff, V. / Chiswell, B.P. / Calderwood, D.A. / Boggon, T.J. CitationJournal : To be Published Title : Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800Authors : Stiegler, A.L. / Jakoncic, J. / Stojanoff, V. / Chiswell, B.P. / Calderwood, D.A. / Boggon, T.J. History Deposition Oct 11, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 11, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Nov 15, 2017 Group : Refinement description / Category : softwareRevision 1.2 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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