- PDB-4hcn: Crystal structure of Burkholderia pseudomallei effector protein C... -
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基本情報
登録情報
データベース: PDB / ID: 4hcn
タイトル
Crystal structure of Burkholderia pseudomallei effector protein CHBP in complex with ubiquitin
要素
Polyubiquitin
Putative ATP/GTP binding protein
キーワード
PROTEIN BINDING / UBIQUITIN/NEDD8 DEAMIDASE / UBIQUITIN / NEDD8
機能・相同性
機能・相同性情報
symbiont-mediated perturbation of host cell cycle progression / Josephin domain DUBs / RAS processing / Regulation of PTEN localization / ER Quality Control Compartment (ERQC) / UCH proteinases / protein-glutamine glutaminase activity / Pexophagy / protein-glutamine glutaminase / Interleukin-1 signaling ...symbiont-mediated perturbation of host cell cycle progression / Josephin domain DUBs / RAS processing / Regulation of PTEN localization / ER Quality Control Compartment (ERQC) / UCH proteinases / protein-glutamine glutaminase activity / Pexophagy / protein-glutamine glutaminase / Interleukin-1 signaling / Aggrephagy / Regulation of pyruvate metabolism / Peroxisomal protein import / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / Metalloprotease DUBs / Endosomal Sorting Complex Required For Transport (ESCRT) / E3 ubiquitin ligases ubiquitinate target proteins / Translesion Synthesis by POLH / Translesion synthesis by REV1 / Translesion synthesis by POLK / Translesion synthesis by POLI / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / Termination of translesion DNA synthesis / Negative regulators of DDX58/IFIH1 signaling / Ubiquitin Mediated Degradation of Phosphorylated Cdc25A / Regulation of PTEN stability and activity / KEAP1-NFE2L2 pathway / CDK-mediated phosphorylation and removal of Cdc6 / Neddylation / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / Formation of TC-NER Pre-Incision Complex / Orc1 removal from chromatin / MAPK6/MAPK4 signaling / SRP-dependent cotranslational protein targeting to membrane / GTP hydrolysis and joining of the 60S ribosomal subunit / Gap-filling DNA repair synthesis and ligation in TC-NER / Formation of a pool of free 40S subunits / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / Antigen processing: Ubiquitination & Proteasome degradation / L13a-mediated translational silencing of Ceruloplasmin expression / Dual incision in TC-NER / Ub-specific processing proteases / modification-dependent protein catabolic process / protein tag activity / peroxisome / toxin activity / protein ubiquitination / ubiquitin protein ligase binding / host cell nucleus / extracellular region / nucleus / cytosol 類似検索 - 分子機能
解像度: 2.6→19.35 Å / Cor.coef. Fo:Fc: 0.908 / Cor.coef. Fo:Fc free: 0.856 / 交差検証法: THROUGHOUT / ESU R Free: 0.381 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.26
1007
9.9 %
RANDOM
Rwork
0.218
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obs
0.222
9211
95.4 %
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溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK