Entry Database : PDB / ID : 4egc Structure visualization Downloads & linksTitle Crystal Structure of MBP-fused Human Six1 Bound to Human Eya2 Eya Domain ComponentsEyes absent homolog 2 Maltose-binding periplasmic protein, Homeobox protein SIX1 chimera DetailsKeywords TRANSCRIPTION/HYDROLASE / homeodomain (HD) / six domain (SD) / eya domain (ED) / haloacid dehalogenase (HAD) / transcription factor / co-activator / protein phosphatase / DNA binding / fusion protein / nucleus / TRANSCRIPTION-HYDROLASE complexFunction / homology Function and homology informationFunction Domain/homology Component
regulation of skeletal muscle cell proliferation / mesonephric tubule formation / cellular response to 3,3',5-triiodo-L-thyronine / ureter smooth muscle cell differentiation / regulation of branch elongation involved in ureteric bud branching / positive regulation of secondary heart field cardioblast proliferation / olfactory placode formation / histone H2AXY142 phosphatase activity / myotome development / fungiform papilla morphogenesis ... regulation of skeletal muscle cell proliferation / mesonephric tubule formation / cellular response to 3,3',5-triiodo-L-thyronine / ureter smooth muscle cell differentiation / regulation of branch elongation involved in ureteric bud branching / positive regulation of secondary heart field cardioblast proliferation / olfactory placode formation / histone H2AXY142 phosphatase activity / myotome development / fungiform papilla morphogenesis / regulation of skeletal muscle cell differentiation / mesodermal cell fate specification / positive regulation of ureteric bud formation / facial nerve morphogenesis / otic vesicle development / regulation of synaptic assembly at neuromuscular junction / anatomical structure development / positive regulation of mesenchymal cell proliferation involved in ureter development / striated muscle tissue development / mitochondrial outer membrane permeabilization / trigeminal ganglion development / metanephric mesenchyme development / cochlea morphogenesis / myoblast migration / neuron fate specification / aorta morphogenesis / regulation of skeletal muscle satellite cell proliferation / embryonic skeletal system morphogenesis / chromatin => GO:0000785 / positive regulation of branching involved in ureteric bud morphogenesis / pattern specification process / pharyngeal system development / organ induction / regulation of epithelial cell proliferation / embryonic cranial skeleton morphogenesis / middle ear morphogenesis / ureteric bud development / regulation of neuron differentiation / branching involved in ureteric bud morphogenesis / inner ear morphogenesis / generation of neurons / detection of maltose stimulus / maltose transport complex / outflow tract morphogenesis / carbohydrate transport / thyroid gland development / inner ear development / carbohydrate transmembrane transporter activity / protein localization to nucleus / maltose binding / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / maltose transport / maltodextrin transmembrane transport / skeletal muscle fiber development / ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing / skeletal muscle tissue development / extrinsic apoptotic signaling pathway in absence of ligand / epithelial cell differentiation / positive regulation of DNA repair / positive regulation of brown fat cell differentiation / ATP-binding cassette (ABC) transporter complex / protein-tyrosine-phosphatase / cell chemotaxis / thymus development / protein tyrosine phosphatase activity / kidney development / sensory perception of sound / transcription coactivator binding / regulation of protein localization / sequence-specific double-stranded DNA binding / Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks / outer membrane-bounded periplasmic space / DNA-binding transcription activator activity, RNA polymerase II-specific / negative regulation of neuron apoptotic process / transcription regulator complex / sequence-specific DNA binding / periplasmic space / cell differentiation / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / DNA repair / negative regulation of DNA-templated transcription / apoptotic process / DNA damage response / chromatin binding / regulation of DNA-templated transcription / nucleolus / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / magnesium ion binding / positive regulation of transcription by RNA polymerase II / mitochondrion / DNA binding / nucleoplasm / membrane / nucleus / cytoplasm / cytosol Similarity search - Function Homeobox protein SIX1 / Homeobox protein SIX1, N-terminal SD domain / Transcriptional regulator, SIX1, N-terminal SD domain / Rossmann fold - #12350 / EYA domain / Eyes absent family / EYA domain superfamily / EYA domain, metazoan / Homeobox, conserved site / 'Homeobox' domain signature. ... Homeobox protein SIX1 / Homeobox protein SIX1, N-terminal SD domain / Transcriptional regulator, SIX1, N-terminal SD domain / Rossmann fold - #12350 / EYA domain / Eyes absent family / EYA domain superfamily / EYA domain, metazoan / Homeobox, conserved site / 'Homeobox' domain signature. / Homeodomain / 'Homeobox' domain profile. / Homeodomain / Homeobox domain / Maltose/Cyclodextrin ABC transporter, substrate-binding protein / Solute-binding family 1, conserved site / Bacterial extracellular solute-binding proteins, family 1 signature. / haloacid dehalogenase-like hydrolase / Bacterial extracellular solute-binding protein / Bacterial extracellular solute-binding protein / HAD-like superfamily / Homeobox-like domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Escherichia coli (E. coli)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 1.994 Å DetailsAuthors Zhao, R. / Patrick, A.N. CitationJournal : Nat.Struct.Mol.Biol. / Year : 2013Title : Structure-function analyses of the human SIX1-EYA2 complex reveal insights into metastasis and BOR syndrome.Authors : Patrick, A.N. / Cabrera, J.H. / Smith, A.L. / Chen, X.S. / Ford, H.L. / Zhao, R. History Deposition Mar 30, 2012 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 27, 2013 Provider : repository / Type : Initial releaseRevision 1.1 Mar 20, 2013 Group : Database referencesRevision 1.2 Apr 17, 2013 Group : Database referencesRevision 1.3 Jul 26, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 2.0 Jul 29, 2020 Group : Atomic model / Data collection ... Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Structure summary Category : atom_site / chem_comp ... atom_site / chem_comp / entity / entity_name_com / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_molecule_features / pdbx_nonpoly_scheme / pdbx_struct_conn_angle / struct_conn / struct_conn_type / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_atom_id / _atom_site.auth_comp_id / _atom_site.auth_seq_id / _atom_site.label_atom_id / _atom_site.label_comp_id / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.id / _chem_comp.mon_nstd_flag / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.type / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_ref_seq_dif.details Description : Carbohydrate remediation / Provider : repository / Type : RemediationRevision 2.1 Feb 28, 2024 Group : Data collection / Database references / Structure summaryCategory : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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