- PDB-4e2i: The Complex Structure of the SV40 Helicase Large T Antigen and p6... -
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Basic information
Entry
Database: PDB / ID: 4e2i
Title
The Complex Structure of the SV40 Helicase Large T Antigen and p68 Subunit of DNA Polymerase Alpha-Primase
Components
DNA polymerase alpha subunit B
Large T antigen
Keywords
Hydrolase/DNA binding Protein / replication initiation / Hydrolase-DNA binding complex / Hydrolase-DNA binding Protein complex
Function / homology
Function and homology information
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity / DNA replication initiation / Telomere C-strand synthesis initiation / Inhibition of replication initiation of damaged DNA by RB1/E2F1 / alpha DNA polymerase:primase complex / Polymerase switching / Processive synthesis on the lagging strand / Removal of the Flap Intermediate / bidirectional double-stranded viral DNA replication / Polymerase switching on the C-strand of the telomere ...symbiont-mediated suppression of host JAK-STAT cascade via inhibition of JAK1 activity / DNA replication initiation / Telomere C-strand synthesis initiation / Inhibition of replication initiation of damaged DNA by RB1/E2F1 / alpha DNA polymerase:primase complex / Polymerase switching / Processive synthesis on the lagging strand / Removal of the Flap Intermediate / bidirectional double-stranded viral DNA replication / Polymerase switching on the C-strand of the telomere / viral DNA genome replication / DNA replication, synthesis of primer / DNA unwinding involved in DNA replication / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / DNA replication origin binding / Activation of the pre-replicative complex / DNA replication initiation / helicase activity / Defective pyroptosis / Hydrolases; Acting on acid anhydrides; Acting on acid anhydrides to facilitate cellular and subcellular movement / protein import into nucleus / single-stranded DNA binding / double-stranded DNA binding / symbiont-mediated perturbation of host ubiquitin-like protein modification / DNA replication / hydrolase activity / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / virus-mediated perturbation of host defense response / host cell nucleus / DNA binding / nucleoplasm / ATP binding / identical protein binding / metal ion binding / cytosol Similarity search - Function
Large T antigen, polyomaviridae / DNA polymerase alpha, subunit B, N-terminal domain superfamily / Large T antigen, polyomavirus, C-terminal / Zinc finger, large T-antigen D1-type / Origin of replication binding protein / Polyomavirus large T antigen C-terminus / Large T-antigen (T-ag) origin-binding domain (OBD) profile. / Zinc finger large T-antigen (T-ag) D1-type profile. / T antigen, Ori-binding / Zinc finger, large T-antigen D1 domain superfamily ...Large T antigen, polyomaviridae / DNA polymerase alpha, subunit B, N-terminal domain superfamily / Large T antigen, polyomavirus, C-terminal / Zinc finger, large T-antigen D1-type / Origin of replication binding protein / Polyomavirus large T antigen C-terminus / Large T-antigen (T-ag) origin-binding domain (OBD) profile. / Zinc finger large T-antigen (T-ag) D1-type profile. / T antigen, Ori-binding / Zinc finger, large T-antigen D1 domain superfamily / DNA polymerase alpha subunit B N-terminal / DNA polymerase alpha, subunit B, N-terminal / DNA polymerase alpha, subunit B / Helicase, superfamily 3, DNA virus / Superfamily 3 helicase of DNA viruses domain profile. / DNA polymerase alpha/delta/epsilon, subunit B / DNA polymerase alpha/epsilon subunit B / DnaJ molecular chaperone homology domain / dnaJ domain profile. / Chaperone J-domain superfamily / DnaJ domain / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homology
A: Large T antigen B: Large T antigen C: Large T antigen D: Large T antigen E: Large T antigen F: Large T antigen G: Large T antigen H: Large T antigen I: Large T antigen J: Large T antigen K: Large T antigen L: Large T antigen 2: DNA polymerase alpha subunit B 3: DNA polymerase alpha subunit B 6: DNA polymerase alpha subunit B U: DNA polymerase alpha subunit B W: DNA polymerase alpha subunit B 5: DNA polymerase alpha subunit B 7: DNA polymerase alpha subunit B 9: DNA polymerase alpha subunit B 1: DNA polymerase alpha subunit B 4: DNA polymerase alpha subunit B 8: DNA polymerase alpha subunit B hetero molecules
A: Large T antigen B: Large T antigen C: Large T antigen D: Large T antigen E: Large T antigen F: Large T antigen 2: DNA polymerase alpha subunit B 3: DNA polymerase alpha subunit B 6: DNA polymerase alpha subunit B 5: DNA polymerase alpha subunit B 1: DNA polymerase alpha subunit B 4: DNA polymerase alpha subunit B hetero molecules
G: Large T antigen H: Large T antigen I: Large T antigen J: Large T antigen K: Large T antigen L: Large T antigen U: DNA polymerase alpha subunit B W: DNA polymerase alpha subunit B 7: DNA polymerase alpha subunit B 9: DNA polymerase alpha subunit B 8: DNA polymerase alpha subunit B hetero molecules
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