登録情報 データベース : PDB / ID : 4deq 構造の表示 ダウンロードとリンクタイトル Structure of the Neuropilin-1/VEGF-A complex 要素Neuropilin-1, Vascular endothelial growth factor A 詳細 キーワード PROTEIN BINDING/CYTOKINE / Coagulation factor domain / heparin binding domain / Angiogenesis / PROTEIN BINDING-CYTOKINE complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
endothelial tip cell fate specification / basal dendrite development / protein localization to early endosome / otic placode development / basal dendrite arborization / dichotomous subdivision of terminal units involved in salivary gland branching / retina vasculature morphogenesis in camera-type eye / regulation of vascular endothelial growth factor receptor signaling pathway / vestibulocochlear nerve structural organization / dorsal root ganglion morphogenesis ... endothelial tip cell fate specification / basal dendrite development / protein localization to early endosome / otic placode development / basal dendrite arborization / dichotomous subdivision of terminal units involved in salivary gland branching / retina vasculature morphogenesis in camera-type eye / regulation of vascular endothelial growth factor receptor signaling pathway / vestibulocochlear nerve structural organization / dorsal root ganglion morphogenesis / basophil chemotaxis / ventral trunk neural crest cell migration / positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway / sympathetic neuron projection guidance / cellular stress response to acid chemical / facioacoustic ganglion development / VEGF-A complex / Signaling by VEGF / trigeminal ganglion development / lymph vessel morphogenesis / neurofilament / positive regulation of lymphangiogenesis / negative regulation of adherens junction organization / postsynapse organization / trigeminal nerve structural organization / vascular endothelial growth factor receptor 1 binding / sensory neuron axon guidance / facial nerve structural organization / gonadotrophin-releasing hormone neuronal migration to the hypothalamus / negative regulation of establishment of endothelial barrier / branchiomotor neuron axon guidance / renal artery morphogenesis / vascular endothelial growth factor receptor binding / VEGF ligand-receptor interactions / positive regulation of mast cell chemotaxis / post-embryonic camera-type eye development / primitive erythrocyte differentiation / positive regulation of protein kinase C signaling / positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway / negative regulation of blood-brain barrier permeability / axon extension involved in axon guidance / VEGF-activated neuropilin signaling pathway / bone trabecula formation / negative regulation of axon extension involved in axon guidance / positive regulation of vascular endothelial growth factor signaling pathway / coronary vein morphogenesis / cardiac vascular smooth muscle cell development / lung vasculature development / lymphangiogenesis / eye photoreceptor cell development / sympathetic neuron projection extension / vascular endothelial growth factor binding / Neurophilin interactions with VEGF and VEGFR / endothelial cell chemotaxis / motor neuron migration / positive regulation of trophoblast cell migration / positive regulation of epithelial tube formation / vascular endothelial growth factor receptor-2 signaling pathway / axonogenesis involved in innervation / VEGF binds to VEGFR leading to receptor dimerization / sympathetic ganglion development / regulation of nitric oxide mediated signal transduction / neural crest cell migration involved in autonomic nervous system development / positive regulation of axon extension involved in axon guidance / vascular wound healing / positive regulation of protein localization to early endosome / CHL1 interactions / regulation of hematopoietic progenitor cell differentiation / vascular endothelial growth factor receptor activity / positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of branching involved in ureteric bud morphogenesis / regulation of vesicle-mediated transport / camera-type eye morphogenesis / Signaling by ROBO receptors / angiogenesis involved in coronary vascular morphogenesis / neuropilin signaling pathway / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / neuropilin binding / induction of positive chemotaxis / coronary artery morphogenesis / hepatocyte growth factor receptor signaling pathway / negative regulation of cell-cell adhesion mediated by cadherin / substrate-dependent cell migration, cell extension / outflow tract septum morphogenesis / vascular endothelial growth factor receptor 2 binding / semaphorin receptor activity / tube formation / positive regulation of vascular permeability / dopaminergic neuron differentiation / CRMPs in Sema3A signaling / commissural neuron axon guidance / negative regulation of epithelial to mesenchymal transition / platelet-derived growth factor receptor binding / surfactant homeostasis / semaphorin receptor complex / extracellular matrix binding / cell migration involved in sprouting angiogenesis / axonal fasciculation / regulation of Cdc42 protein signal transduction / motor neuron axon guidance 類似検索 - 分子機能 Vascular Endothelial Growth Factor-165, Heparin-binding Domain / Vascular endothelial growth factor, heparin-binding domain / Neuropilin / Neuropilin, C-terminal / C-terminal domain of neuropilin glycoprotein / Vascular endothelial growth factor, heparin-binding domain / Vascular endothelial growth factor, heparin-binding domain superfamily / VEGF heparin-binding domain / MAM domain signature. / PDGF/VEGF domain ... Vascular Endothelial Growth Factor-165, Heparin-binding Domain / Vascular endothelial growth factor, heparin-binding domain / Neuropilin / Neuropilin, C-terminal / C-terminal domain of neuropilin glycoprotein / Vascular endothelial growth factor, heparin-binding domain / Vascular endothelial growth factor, heparin-binding domain superfamily / VEGF heparin-binding domain / MAM domain signature. / PDGF/VEGF domain / Platelet-derived growth factor, conserved site / PDGF/VEGF domain / Platelet-derived growth factor (PDGF) family signature. / Platelet-derived growth factor (PDGF) family profile. / Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family / Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others) / MAM domain, meprin/A5/mu / MAM domain / MAM domain profile. / Coagulation factors 5/8 type C domain (FA58C) signature 2. / Coagulation factors 5/8 type C domain (FA58C) signature 1. / CUB domain / Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein. / CUB domain / CUB domain profile. / Spermadhesin, CUB domain superfamily / Coagulation factor 5/8 C-terminal domain, discoidin domain / Coagulation factors 5/8 type C domain (FA58C) profile. / Cystine-knot cytokine / F5/8 type C domain / Coagulation factor 5/8 C-terminal domain / Galactose-binding domain-like / Galactose-binding-like domain superfamily / Ribbon / Concanavalin A-like lectin/glucanase domain superfamily / Jelly Rolls / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性 PHOSPHATE ION / Neuropilin-1 / Vascular endothelial growth factor A, long form 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.649 Å 詳細データ登録者 Vander Kooi, C.W. 引用ジャーナル : J.Biol.Chem. / 年 : 2012タイトル : Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1.著者 : Parker, M.W. / Xu, P. / Li, X. / Vander Kooi, C.W. 履歴 登録 2012年1月21日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2012年2月8日 Provider : repository / タイプ : Initial release改定 1.1 2012年2月29日 Group : Database references改定 1.2 2012年7月18日 Group : Database references改定 1.3 2017年8月2日 Group : Refinement description / Source and taxonomy / カテゴリ : entity_src_gen / software改定 1.4 2023年9月13日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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