登録情報 | データベース: PDB / ID: 4d1e |
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タイトル | THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2 |
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要素 | ALPHA-ACTININ-2 |
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キーワード | CONTRACTILE PROTEIN / Z-DISC / CALMODULIN-LIKE DOMAIN / SPECTRIN DOMAIN / ACTIN BINDING DOMAIN / ABD |
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機能・相同性 | 機能・相同性情報
actin filament uncapping / FATZ binding / titin Z domain binding / phospholipase C-activating angiotensin-activated signaling pathway / positive regulation of endocytic recycling / positive regulation of cation channel activity / negative regulation of protein localization to cell surface / channel activator activity / LIM domain binding / microspike assembly ...actin filament uncapping / FATZ binding / titin Z domain binding / phospholipase C-activating angiotensin-activated signaling pathway / positive regulation of endocytic recycling / positive regulation of cation channel activity / negative regulation of protein localization to cell surface / channel activator activity / LIM domain binding / microspike assembly / structural constituent of postsynaptic actin cytoskeleton / postsynaptic actin cytoskeleton / positive regulation of potassium ion transport / focal adhesion assembly / muscle cell development / Striated Muscle Contraction / Nephrin family interactions / Assembly and cell surface presentation of NMDA receptors / cardiac muscle cell development / structural constituent of muscle / sarcomere organization / cortical actin cytoskeleton / pseudopodium / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / negative regulation of potassium ion transport / Long-term potentiation / postsynaptic density, intracellular component / cytoskeletal protein binding / titin binding / phosphatidylinositol-4,5-bisphosphate binding / Ras activation upon Ca2+ influx through NMDA receptor / platelet alpha granule lumen / regulation of membrane potential / cell projection / protein localization to plasma membrane / filopodium / actin filament / postsynaptic density membrane / Z disc / actin filament binding / integrin binding / cell junction / Platelet degranulation / actin cytoskeleton organization / RAF/MAP kinase cascade / regulation of apoptotic process / dendritic spine / transmembrane transporter binding / cytoskeleton / transcription coactivator activity / cell adhesion / protein domain specific binding / focal adhesion / calcium ion binding / glutamatergic synapse / extracellular exosome / extracellular region / identical protein binding / cytosol類似検索 - 分子機能 EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Spectrin repeats / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Actinin-type actin-binding domain, conserved site ...EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Spectrin repeat / Spectrin repeat / Spectrin/alpha-actinin / Spectrin repeats / Actinin-type actin-binding domain signature 1. / Actinin-type actin-binding domain signature 2. / Actinin-type actin-binding domain, conserved site / Calponin homology domain / Calponin homology (CH) domain / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / EF-hand / Recoverin; domain 1 / EF-hand domain pair / EF-hand, calcium binding motif / EF-hand calcium-binding domain profile. / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.5 Å |
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データ登録者 | Pinotsis, N. / Salmazo, A. / Sjoeblom, B. / Gkougkoulia, E. / Djinovic-Carugo, K. |
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引用 | ジャーナル: Cell(Cambridge,Mass.) / 年: 2014 タイトル: The Structure and Regulation of Human Muscle Alpha-Actinin 著者: Ribeiro Jr, E.A. / Pinotsis, N. / Ghisleni, A. / Salmazo, A. / Konarev, P.V. / Kostan, J. / Sjoeblom, B. / Schreiner, C. / Polyansky, A.A. / Gkougkoulia, E. / Holt, M.R. / Aachmann, F.L. / ...著者: Ribeiro Jr, E.A. / Pinotsis, N. / Ghisleni, A. / Salmazo, A. / Konarev, P.V. / Kostan, J. / Sjoeblom, B. / Schreiner, C. / Polyansky, A.A. / Gkougkoulia, E. / Holt, M.R. / Aachmann, F.L. / Zagrovic, B. / Bordignon, E. / Pirker, K.F. / Svergun, D.I. / Gautel, M. / Djinovic-Carugo, K. |
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履歴 | 登録 | 2014年5月1日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2014年12月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2014年12月17日 | Group: Database references |
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改定 1.2 | 2023年12月20日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model / struct_conn Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_conn.pdbx_leaving_atom_flag |
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