Entry | Database: PDB / ID: 4c9y |
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Title | Structural Basis for the microtubule binding of the human kinetochore Ska complex |
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Components | SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1 |
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Keywords | CELL CYCLE / CELL DIVISON / KINETOCHORE-MICROTUBULE ATTACHMENT / WINGED-HELIX DOMAIN |
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Function / homology | Function and homology information
outer kinetochore / attachment of mitotic spindle microtubules to kinetochore / intercellular bridge / centriolar satellite / regulation of microtubule polymerization or depolymerization / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Resolution of Sister Chromatid Cohesion / chromosome segregation ...outer kinetochore / attachment of mitotic spindle microtubules to kinetochore / intercellular bridge / centriolar satellite / regulation of microtubule polymerization or depolymerization / Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / Resolution of Sister Chromatid Cohesion / chromosome segregation / RHO GTPases Activate Formins / spindle microtubule / mitotic spindle / kinetochore / Separation of Sister Chromatids / microtubule cytoskeleton / mitotic cell cycle / microtubule binding / cell division / cytosolSimilarity search - Function Ska1 microtubule binding domain-like / Spindle and kinetochore-associated protein 1 / SKA1 microtubule binding domain / Spindle and kinetochore-associated protein 1 / Arc Repressor Mutant, subunit A / Orthogonal Bundle / Mainly AlphaSimilarity search - Domain/homology |
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Biological species | HOMO SAPIENS (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution: 2.01 Å |
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Authors | Abad, M. / Medina, B. / Santamaria, A. / Zou, J. / Plasberg-Hill, C. / Madhumalar, A. / Jayachandran, U. / Redli, P.M. / Rappsilber, J. / Nigg, E.A. / Jeyaprakash, A.A. |
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Citation | Journal: Nat.Commun. / Year: 2014 Title: Structural Basis for Microtubule Recognition by the Human Kinetochore Ska Complex. Authors: Abad, M.A. / Medina, B. / Santamaria, A. / Zou, J. / Plasberg-Hill, C. / Madhumalar, A. / Jayachandran, U. / Redli, P.M. / Rappsilber, J. / Nigg, E.A. / Jeyaprakash, A.A. |
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History | Deposition | Oct 4, 2013 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Jan 22, 2014 | Provider: repository / Type: Initial release |
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