登録情報 データベース : PDB / ID : 4c66 構造の表示 ダウンロードとリンクタイトル Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains 要素BROMODOMAIN-CONTAINING PROTEIN 4 BRD4 詳細 キーワード CELL CYCLE (細胞周期) / TRANSCRIPTION REGULATION / INHIBITOR (酵素阻害剤) / EPIGENETIC READER / ANTAGONIST (受容体拮抗薬)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / transcription coregulator activity ... RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / transcription coregulator activity / positive regulation of transcription elongation by RNA polymerase II / lysine-acetylated histone binding / p53 binding / 染色体 / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / クロマチンリモデリング / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / 核質 / 細胞核 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / ブロモドメイン / Bromodomain profile. / bromo domain / ブロモドメイン / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.87 Å 詳細データ登録者 Chung, C. / Mirguet, O. 引用ジャーナル : J.Med.Chem. / 年 : 2013タイトル : Discovery of Epigenetic Regulator I-Bet762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the Bet Bromodomains.著者: Mirguet, O. / Gosmini, R. / Toum, J. / Clement, C. / Barnathan, M. / Brusq, J. / Mordaunt, J.E. / Grimes, R. / Crowe, M. / Pineau, O. / Ajakane, M. / Daugan, A. / Jeffrey, P. / Cutler, L. / ... 著者 : Mirguet, O. / Gosmini, R. / Toum, J. / Clement, C. / Barnathan, M. / Brusq, J. / Mordaunt, J.E. / Grimes, R. / Crowe, M. / Pineau, O. / Ajakane, M. / Daugan, A. / Jeffrey, P. / Cutler, L. / Haynes, A. / Smithers, N. / Chung, C. / Bamborough, P. / Uings, I.J. / Lewis, T. / Witherington, J. / Parr, N. / Prinjha, R. / Nicodeme, E. 履歴 登録 2013年9月17日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2013年10月2日 Provider : repository / タイプ : Initial release改定 1.1 2013年10月30日 Group : Database references改定 1.2 2024年5月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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