Entry | Database: PDB / ID: 4axg |
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Title | Structure of eIF4E-Cup complex |
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Components | - EUKARYOTIC TRANSLATION INITIATION FACTOR 4E
- PROTEIN CUP
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Keywords | TRANSLATION / 4E-BP / MRNA LOCALIZATION |
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Function / homology | Function and homology information
oocyte growth in germarium-derived egg chamber / negative regulation of eukaryotic translation initiation factor 4F complex assembly / follicle cell of egg chamber migration / negative regulation of oskar mRNA translation / TOR signaling pathway / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / ISG15 antiviral mechanism / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / Transport of Mature mRNA Derived from an Intronless Transcript ...oocyte growth in germarium-derived egg chamber / negative regulation of eukaryotic translation initiation factor 4F complex assembly / follicle cell of egg chamber migration / negative regulation of oskar mRNA translation / TOR signaling pathway / Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S / ISG15 antiviral mechanism / Transport of the SLBP independent Mature mRNA / Transport of the SLBP Dependant Mature mRNA / Transport of Mature mRNA Derived from an Intronless Transcript / mTORC1-mediated signalling / Ribosomal scanning and start codon recognition / L13a-mediated translational silencing of Ceruloplasmin expression / Translation initiation complex formation / muscle cell postsynaptic specialization / regulation of pole plasm oskar mRNA localization / trans-synaptic signaling / regulation of synaptic assembly at neuromuscular junction / : / neuronal ribonucleoprotein granule / RNA metabolic process / meiotic chromosome segregation / eukaryotic initiation factor 4G binding / eukaryotic initiation factor 4E binding / regulation of translation at postsynapse, modulating synaptic transmission / RNA cap binding / intracellular mRNA localization / female meiotic nuclear division / eukaryotic translation initiation factor 4F complex / RNA 7-methylguanosine cap binding / dorsal/ventral pattern formation / oogenesis / translation regulator activity / negative regulation of translational initiation / translational initiation / translation initiation factor activity / P-body / neuromuscular junction / terminal bouton / postsynapse / nuclear body / negative regulation of translation / translation / mRNA binding / RNA binding / nucleus / cytoplasm / cytosolSimilarity search - Function Eukaryotic translation initiation factor 4E binding protein / Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E / RNA Cap, Translation Initiation Factor Eif4e / RNA Cap, Translation Initiation Factor Eif4e / Eukaryotic translation initiation factor 4E (eIF-4E), conserved site / Eukaryotic initiation factor 4E signature. / Translation Initiation factor eIF- 4e / Eukaryotic initiation factor 4E / Translation Initiation factor eIF- 4e-like / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | DROSOPHILA MELANOGASTER (fruit fly) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.8 Å |
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Authors | Kinkelin, K. / Veith, K. / Gruenwald, M. / Bono, F. |
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Citation | Journal: RNA / Year: 2012 Title: Crystal Structure of a Minimal Eif4E-Cup Complex Revelas a General Mechanism of Eif4E Regulation in Translational Repression Authors: Kinkelin, K. / Veith, K. / Gruenwald, M. / Bono, F. |
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History | Deposition | Jun 12, 2012 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Aug 29, 2012 | Provider: repository / Type: Initial release |
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Revision 1.1 | Dec 20, 2023 | Group: Data collection / Database references ...Data collection / Database references / Other / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf |
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