SIGNALING PROTEIN / STRUCTURAL GENOMICS CONSORTIUM / SGC / SIGNALING
Function / homology
Function and homology information
Inhibition of membrane repair / ESCRT-0 complex / membrane invagination / regulation of MAP kinase activity / phagocytic vesicle lumen / protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway / protein targeting to lysosome / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / membrane fission ...Inhibition of membrane repair / ESCRT-0 complex / membrane invagination / regulation of MAP kinase activity / phagocytic vesicle lumen / protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway / protein targeting to lysosome / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / membrane fission / multivesicular body membrane / positive regulation of exosomal secretion / multivesicular body assembly / endocytic recycling / protein localization to membrane / negative regulation of platelet-derived growth factor receptor signaling pathway / endosomal transport / Lysosome Vesicle Biogenesis / negative regulation of vascular endothelial growth factor receptor signaling pathway / regulation of protein catabolic process / ubiquitin-like protein ligase binding / RHOU GTPase cycle / Prevention of phagosomal-lysosomal fusion / Endosomal Sorting Complex Required For Transport (ESCRT) / phosphatidylinositol binding / negative regulation of angiogenesis / InlB-mediated entry of Listeria monocytogenes into host cell / ubiquitin binding / macroautophagy / EGFR downregulation / Negative regulation of MET activity / receptor internalization / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / early endosome membrane / early endosome / lysosome / Ub-specific processing proteases / endosome / protein domain specific binding / negative regulation of cell population proliferation / positive regulation of gene expression / signal transduction / extracellular exosome / metal ion binding / cytosol Similarity search - Function
Resolution: 1.68→55.83 Å / Cor.coef. Fo:Fc: 0.958 / Cor.coef. Fo:Fc free: 0.937 / SU B: 4.014 / SU ML: 0.075 / Cross valid method: THROUGHOUT / ESU R: 0.119 / ESU R Free: 0.121 / Stereochemistry target values: MAXIMUM LIKELIHOOD Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS. U VALUES WITH TLS ADDED.
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.23103
1167
5.1 %
RANDOM
Rwork
0.18108
-
-
-
obs
0.18357
21700
96.58 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK