登録情報 データベース : PDB / ID : 4agw 構造の表示 ダウンロードとリンクタイトル Discovery of a small molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases 要素PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC 詳細 キーワード TRANSFERASE / ATP-BINDING / LIPOPROTEIN / MYRISTATE / PHOSPHOPROTEIN / SH2 DOMAIN / SH3 DOMAIN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Signaling by ERBB2 / Nuclear signaling by ERBB4 / PIP3 activates AKT signaling / Signaling by SCF-KIT / Regulation of KIT signaling / Signaling by EGFR / GAB1 signalosome / Regulation of gap junction activity / FCGR activation / PECAM1 interactions ... Signaling by ERBB2 / Nuclear signaling by ERBB4 / PIP3 activates AKT signaling / Signaling by SCF-KIT / Regulation of KIT signaling / Signaling by EGFR / GAB1 signalosome / Regulation of gap junction activity / FCGR activation / PECAM1 interactions / CD28 co-stimulation / CTLA4 inhibitory signaling / EPHA-mediated growth cone collapse / Ephrin signaling / G alpha (i) signalling events / GP1b-IX-V activation signalling / Thrombin signalling through proteinase activated receptors (PARs) / VEGFR2 mediated cell proliferation / RAF activation / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RET signaling / Receptor Mediated Mitophagy / ADP signalling through P2Y purinoceptor 1 / Downregulation of ERBB4 signaling / EPH-ephrin mediated repulsion of cells / Cyclin D associated events in G1 / Regulation of RUNX3 expression and activity / Activated NTRK3 signals through PI3K / Downstream signal transduction / MAP2K and MAPK activation / Integrin signaling / GRB2:SOS provides linkage to MAPK signaling for Integrins / DCC mediated attractive signaling / MET activates PTK2 signaling / Extra-nuclear estrogen signaling / EPHB-mediated forward signaling / p130Cas linkage to MAPK signaling for integrins / VEGFA-VEGFR2 Pathway / connexin binding / progesterone receptor signaling pathway / negative regulation of intrinsic apoptotic signaling pathway / negative regulation of extrinsic apoptotic signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / epidermal growth factor receptor signaling pathway / cell junction / protein phosphatase binding / protein tyrosine kinase activity / mitochondrial inner membrane / cell differentiation / cytoskeleton / regulation of cell cycle / endosome membrane / cell adhesion / innate immune response / signaling receptor binding / focal adhesion / heme binding / perinuclear region of cytoplasm / protein-containing complex / ATP binding / membrane / nucleus / plasma membrane / cytosol 類似検索 - 分子機能 : / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. ... : / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Chem-NG7 / Proto-oncogene tyrosine-protein kinase Src 類似検索 - 構成要素生物種 GALLUS GALLUS (ニワトリ)手法 X線回折 / シンクロトロン / OTHER / 解像度 : 2.6 Å 詳細データ登録者 Weisberg, E. / Choi, H.G. / Seeliger, M. / Gray, N. / Griffin, J.D. 引用ジャーナル : Blood / 年 : 2010タイトル : Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of Bcr-Abl, Pdgfralpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants.著者: Weisberg, E. / Choi, H.G. / Ray, A. / Barrett, R. / Zhang, J. / Sim, T. / Zhou, W. / Seeliger, M. / Cameron, M. / Azam, M. / Fletcher, J.A. / Debiec-Rychter, M. / Mayeda, M. / Moreno, D. / ... 著者 : Weisberg, E. / Choi, H.G. / Ray, A. / Barrett, R. / Zhang, J. / Sim, T. / Zhou, W. / Seeliger, M. / Cameron, M. / Azam, M. / Fletcher, J.A. / Debiec-Rychter, M. / Mayeda, M. / Moreno, D. / Kung, A.L. / Janne, P.A. / Khosravi-Far, R. / Melo, J.V. / Manley, P.W. / Adamia, S. / Wu, C. / Gray, N. / Griffin, J.D. 履歴 登録 2012年2月1日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2012年2月15日 Provider : repository / タイプ : Initial release改定 1.1 2019年2月27日 Group : Data collection / Experimental preparation / Otherカテゴリ : exptl_crystal_grow / pdbx_database_proc ... exptl_crystal_grow / pdbx_database_proc / pdbx_database_status / struct_biol Item : _exptl_crystal_grow.method / _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approval改定 1.2 2021年4月28日 Group : Data collection / Derived calculations ... Data collection / Derived calculations / Other / Structure summary カテゴリ : chem_comp / entity ... chem_comp / entity / pdbx_database_status / pdbx_entity_nonpoly / reflns / struct_site Item : _chem_comp.name / _entity.pdbx_description ... _chem_comp.name / _entity.pdbx_description / _pdbx_database_status.status_code_sf / _pdbx_entity_nonpoly.name / _reflns.pdbx_redundancy / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.3 2024年5月8日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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