登録情報 | データベース: PDB / ID: 4a9i |
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タイトル | N-TERMINAL BROMODOMAIN OF HUMAN BRD2 WITH 3-methyl-1,2,3,4- tetrahydroquinazolin-2-one |
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要素 | BROMODOMAIN CONTAINING 2 |
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キーワード | SIGNALING PROTEIN / INHIBITOR / HISTONE / EPIGENETIC READER |
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機能・相同性 | 機能・相同性情報
acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck ...acetylation-dependent protein binding / chromatin looping / RUNX3 regulates p14-ARF / positive regulation of T-helper 17 cell lineage commitment / protein localization to chromatin / neural tube closure / lysine-acetylated histone binding / nucleosome assembly / spermatogenesis / nuclear speck / protein phosphorylation / protein serine/threonine kinase activity / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. ...NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha類似検索 - ドメイン・相同性 1-[1-(PYRIDIN-2-YL)INDOLIZIN-3-YL]ETHAN-1-ONE / Bromodomain-containing protein 2類似検索 - 構成要素 |
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生物種 | HOMO SAPIENS (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.25 Å |
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データ登録者 | Chung, C.W. / Bamborough, P. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2012 タイトル: Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery. 著者: Chung, C.W. / Dean, A.W. / Woolven, J.M. / Bamborough, P. |
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履歴 | 登録 | 2011年11月26日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2012年1月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年2月8日 | Group: Other |
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改定 1.2 | 2019年5月8日 | Group: Data collection / Experimental preparation / Other カテゴリ: exptl_crystal_grow / pdbx_database_proc / pdbx_database_status Item: _exptl_crystal_grow.temp / _pdbx_database_status.recvd_author_approval |
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改定 1.3 | 2024年5月8日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Other カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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